Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              19     665
NP_004229                                                              17    2528
NP_001271144                                                           17    2528
NP_001271143                                                           17    2528
NP_001271145                                                           17    2528
XP_006712916                                                           17    2528
XP_005247020                                                           17    2528
XP_005247019                                                           17    2528
XP_006712915                                                           17    2528
XP_005247018                                                           17    2528
XP_005247017                                                           17    2528
XP_005247015                                                           17    2528
XP_005247014                                                           17    2528
XP_005247013                                                           17    2528
XP_005247012                                                           17    2528
XP_005247011                                                           17    2528
NP_060919                                                              17    4312
NP_001070993                                                           17    4312
NP_001269458                                                           17    4312
NP_071930                                                              17    4312
XP_005257435                                                           17    4312
XP_006721972                                                           17    4312
XP_005257434                                                           17    4312
XP_005257433                                                           17    4312
XP_005265457                                                           17    4312
NP_001070994                                                           17    4312
NP_848591                                                              17    4312
NP_002392                                                              17    4312
NP_976226                                                              17    4312
NP_000657                                                              16    5631
NP_001185827                                                           16    5631
NP_001185824                                                           16    5631
NP_001185825                                                           16    5631
NP_003255                                                              16    7355
NP_065983                                                              16    7355
NP_149038                                                              16    7355
NP_620135                                                              16    7355
NP_001156807                                                           16    7355
NP_055833                                                              16    7355
NP_001186871                                                           16    7355
XP_006715464                                                           16    7355
XP_006715463                                                           16    7355
XP_006715462                                                           16    7355
XP_006715461                                                           16    7355
XP_006715460                                                           16    7355
XP_006715459                                                           16    7355
XP_006715458                                                           16    7355
XP_006715457                                                           16    7355
XP_006715456                                                           16    7355
XP_005263250                                                           16    7355
XP_005263252                                                           16    7355
XP_005263253                                                           16    7355
XP_005263254                                                           16    7355
XP_005263251                                                           16    7355
NP_005189                                                              15    9605
NP_066964                                                              15    9605
NP_705932                                                              15    9605
NP_705934                                                              15    9605
NP_705933                                                              15    9605
NP_001677                                                              15    9605
NP_055840                                                              15    9605
NP_001230925                                                           15    9605
NP_001027                                                              15    9605
NP_722576                                                              15    9605
XP_005262424                                                           15    9605
XP_005267398                                                           15    9605
XP_005246893                                                           15    9605
XP_006711931                                                           15    9605
XP_006711930                                                           15    9605
XP_006711929                                                           15    9605
XP_006711928                                                           15    9605
XP_006711927                                                           15    9605
XP_006711926                                                           15    9605
XP_006711925                                                           15    9605
>NP_000312
          Length = 928

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           KGSTT VNS
Sbjct: 616 KGSTTRVNS 624
>NP_004229
          Length = 1992

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GSTTSVNS 9
           GSTTSV+S
Sbjct: 955 GSTTSVSS 962
>NP_001271144
          Length = 2025

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GSTTSVNS 9
           GSTTSV+S
Sbjct: 988 GSTTSVSS 995
>NP_001271143
          Length = 2040

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    GSTTSVNS 9
            GSTTSV+S
Sbjct: 1003 GSTTSVSS 1010
>NP_001271145
          Length = 1722

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GSTTSVNS 9
           GSTTSV+S
Sbjct: 685 GSTTSVSS 692
>XP_006712916
          Length = 1998

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GSTTSVNS 9
           GSTTSV+S
Sbjct: 961 GSTTSVSS 968
>XP_005247020
          Length = 2013

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    GSTTSVNS 9
            GSTTSV+S
Sbjct: 1031 GSTTSVSS 1038
>XP_005247019
          Length = 2025

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GSTTSVNS 9
           GSTTSV+S
Sbjct: 988 GSTTSVSS 995
>XP_006712915
          Length = 2026

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GSTTSVNS 9
           GSTTSV+S
Sbjct: 989 GSTTSVSS 996
>XP_005247018
          Length = 2026

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GSTTSVNS 9
           GSTTSV+S
Sbjct: 989 GSTTSVSS 996
>XP_005247017
          Length = 2039

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    GSTTSVNS 9
            GSTTSV+S
Sbjct: 1002 GSTTSVSS 1009
>XP_005247015
          Length = 2041

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    GSTTSVNS 9
            GSTTSV+S
Sbjct: 1004 GSTTSVSS 1011
>XP_005247014
          Length = 2063

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    GSTTSVNS 9
            GSTTSV+S
Sbjct: 1031 GSTTSVSS 1038
>XP_005247013
          Length = 2067

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    GSTTSVNS 9
            GSTTSV+S
Sbjct: 1030 GSTTSVSS 1037
>XP_005247012
          Length = 2068

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    GSTTSVNS 9
            GSTTSV+S
Sbjct: 1031 GSTTSVSS 1038
>XP_005247011
          Length = 2068

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    GSTTSVNS 9
            GSTTSV+S
Sbjct: 1031 GSTTSVSS 1038
>NP_060919
          Length = 1119

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   GSTTSVNS 9
           GS+T+VNS
Sbjct: 339 GSSTAVNS 346
>NP_001070993
          Length = 650

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GSTTS+ S
Sbjct: 436 RGSTTSLGS 444
>NP_001269458
          Length = 852

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  GSTTSVNS 9
          GS+T+VNS
Sbjct: 72 GSSTAVNS 79
>NP_071930
          Length = 538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GSTTS+ S
Sbjct: 436 RGSTTSLGS 444
>XP_005257435
          Length = 532

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GS TS+NS
Sbjct: 223 QGSYTSINS 231
>XP_006721972
          Length = 541

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GS TS+NS
Sbjct: 107 QGSYTSINS 115
>XP_005257434
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GS TS+NS
Sbjct: 192 QGSYTSINS 200
>XP_005257433
          Length = 653

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GS TS+NS
Sbjct: 223 QGSYTSINS 231
>XP_005265457
          Length = 625

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GSTTS+ S
Sbjct: 411 RGSTTSLGS 419
>NP_001070994
          Length = 598

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GSTTS+ S
Sbjct: 436 RGSTTSLGS 444
>NP_848591
          Length = 491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GSTTS+ S
Sbjct: 431 RGSTTSIPS 439
>NP_002392
          Length = 626

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GS TS+NS
Sbjct: 192 QGSYTSINS 200
>NP_976226
          Length = 657

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KGSTTSVNS 9
           +GS TS+NS
Sbjct: 223 QGSYTSINS 231
>NP_000657
          Length = 408

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSTTSVN 8
           +GS TSVN
Sbjct: 245 EGSVTSVN 252
>NP_001185827
          Length = 373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSTTSVN 8
           +GS TSVN
Sbjct: 210 EGSVTSVN 217
>NP_001185824
          Length = 408

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSTTSVN 8
           +GS TSVN
Sbjct: 245 EGSVTSVN 252
>NP_001185825
          Length = 336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSTTSVN 8
           +GS TSVN
Sbjct: 173 EGSVTSVN 180
>NP_003255
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KGSTTSVNS 9
          KGS+ S+NS
Sbjct: 37 KGSSGSLNS 45
>NP_065983
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSTTSV 7
           KGS+TSV
Sbjct: 290 KGSSTSV 296
>NP_149038
          Length = 512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STTSVNS 9
           STT+VNS
Sbjct: 108 STTNVNS 114
>NP_620135
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STTSVNS 9
           STTS+NS
Sbjct: 384 STTSLNS 390
>NP_001156807
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   STTSVNS 9
           STTS+NS
Sbjct: 384 STTSLNS 390
>NP_055833
          Length = 2465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>NP_001186871
          Length = 2476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1395 STTSVNN 1401
>XP_006715464
          Length = 2027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>XP_006715463
          Length = 2434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>XP_006715462
          Length = 2452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1371 STTSVNN 1377
>XP_006715461
          Length = 2456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1395 STTSVNN 1401
>XP_006715460
          Length = 2465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>XP_006715459
          Length = 2475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1394 STTSVNN 1400
>XP_006715458
          Length = 2476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1395 STTSVNN 1401
>XP_006715457
          Length = 2485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>XP_006715456
          Length = 2485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    STTSVNS 9
            STTSVN+
Sbjct: 1404 STTSVNN 1410
>XP_005263250
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KGSTTSVNS 9
          KGS+ S+NS
Sbjct: 37 KGSSGSLNS 45
>XP_005263252
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KGSTTSVNS 9
          KGS+ S+NS
Sbjct: 37 KGSSGSLNS 45
>XP_005263253
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KGSTTSVNS 9
          KGS+ S+NS
Sbjct: 37 KGSSGSLNS 45
>XP_005263254
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KGSTTSVNS 9
          KGS+ S+NS
Sbjct: 37 KGSSGSLNS 45
>XP_005263251
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KGSTTSVNS 9
          KGS+ S+NS
Sbjct: 37 KGSSGSLNS 45
>NP_005189
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KGSTTSVNS 9
           KG  TSV+S
Sbjct: 385 KGQLTSVHS 393
>NP_066964
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KGSTTSVNS 9
           +GS TSV S
Sbjct: 583 EGSVTSVGS 591
>NP_705932
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSTTSVNS 9
           GST  +NS
Sbjct: 548 GSTVKINS 555
>NP_705934
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSTTSVNS 9
           GST  +NS
Sbjct: 484 GSTVKINS 491
>NP_705933
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSTTSVNS 9
           GST  +NS
Sbjct: 529 GSTVKINS 536
>NP_001677
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KGSTTSVNS 9
           KGS TSV +
Sbjct: 351 KGSITSVQA 359
>NP_055840
          Length = 1184

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TTSVNS 9
           TTSVNS
Sbjct: 412 TTSVNS 417
>NP_001230925
          Length = 4865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    GSTTSVN 8
            G+TT+VN
Sbjct: 3754 GNTTTVN 3760
>NP_001027
          Length = 4870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    GSTTSVN 8
            G+TT+VN
Sbjct: 3759 GNTTTVN 3765
>NP_722576
          Length = 3080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TTSVNS 9
            TTSVNS
Sbjct: 1224 TTSVNS 1229
>XP_005262424
          Length = 2875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TTSVNS 9
            TTSVNS
Sbjct: 1019 TTSVNS 1024
>XP_005267398
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSTTSVNS 9
           GST  +NS
Sbjct: 548 GSTVKINS 555
>XP_005246893
          Length = 827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KGSTTSVNS 9
           +GS TSV S
Sbjct: 678 EGSVTSVGS 686
>XP_006711931
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TTSVNS 9
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711930
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TTSVNS 9
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711929
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TTSVNS 9
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711928
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TTSVNS 9
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711927
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TTSVNS 9
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711926
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TTSVNS 9
           TTSVNS
Sbjct: 412 TTSVNS 417
>XP_006711925
          Length = 1209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TTSVNS 9
           TTSVNS
Sbjct: 412 TTSVNS 417
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.277   0.0942    0.217 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 453,448
Number of extensions: 932
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.6 bits)
S2: 28 (15.4 bits)

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