Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     665
NP_001075109                                                           19     665
NP_859074                                                              17    2528
XP_006716397                                                           17    2528
XP_006716396                                                           17    2528
XP_006716395                                                           17    2528
XP_006716394                                                           17    2528
XP_005273535                                                           17    2528
XP_006716393                                                           17    2528
XP_006716392                                                           17    2528
XP_006716391                                                           17    2528
XP_005273534                                                           17    2528
NP_940895                                                              16    5631
NP_002763                                                              16    5631
NP_006083                                                              16    7355
NP_689966                                                              16    7355
XP_005249633                                                           16    7355
XP_006715700                                                           16    7355
XP_006715699                                                           16    7355
XP_005249632                                                           16    7355
XP_005249631                                                           16    7355
XP_005249630                                                           16    7355
XP_006715698                                                           16    7355
XP_006715697                                                           16    7355
XP_005249629                                                           16    7355
XP_006715696                                                           16    7355
XP_005249625                                                           16    7355
XP_005249005                                                           16    7355
XP_005249004                                                           16    7355
XP_005249003                                                           16    7355
XP_005249000                                                           16    7355
NP_006531                                                              15    9605
NP_065910                                                              15    9605
NP_001106205                                                           15    9605
NP_115883                                                              15    9605
NP_001159484                                                           15    9605
NP_001275640                                                           15    9605
XP_006722435                                                           15    9605
XP_005258240                                                           15    9605
XP_006722434                                                           15    9605
XP_005251190                                                           15    9605
XP_005251188                                                           15    9605
XP_005251189                                                           15    9605
XP_005251187                                                           15    9605
XP_005251186                                                           15    9605
XP_005251185                                                           15    9605
XP_006714345                                                           15    9605
XP_005263219                                                           15    9605
XP_005263883                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KGSSKLLRM 9
            KG SKLLRM
Sbjct: 3646 KGGSKLLRM 3654
>NP_001075109
          Length = 4097

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KGSSKLLRM 9
            KG SKLLRM
Sbjct: 3646 KGGSKLLRM 3654
>NP_859074
          Length = 530

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGSSKL R
Sbjct: 203 KGSSKLFR 210
>XP_006716397
          Length = 302

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGSSKL R
Sbjct: 203 KGSSKLFR 210
>XP_006716396
          Length = 304

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGSSKL R
Sbjct: 203 KGSSKLFR 210
>XP_006716395
          Length = 305

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGSSKL R
Sbjct: 203 KGSSKLFR 210
>XP_006716394
          Length = 317

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGSSKL R
Sbjct: 203 KGSSKLFR 210
>XP_005273535
          Length = 354

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  KGSSKLLR 8
          KGSSKL R
Sbjct: 27 KGSSKLFR 34
>XP_006716393
          Length = 407

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGSSKL R
Sbjct: 203 KGSSKLFR 210
>XP_006716392
          Length = 485

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGSSKL R
Sbjct: 203 KGSSKLFR 210
>XP_006716391
          Length = 498

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGSSKL R
Sbjct: 203 KGSSKLFR 210
>XP_005273534
          Length = 517

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGSSKL R
Sbjct: 203 KGSSKLFR 210
>NP_940895
          Length = 266

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGS KLL+
Sbjct: 187 KGSGKLLK 194
>NP_002763
          Length = 1019

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GSSKLLR 8
           GSSK+LR
Sbjct: 287 GSSKILR 293
>NP_006083
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>NP_689966
          Length = 993

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGS K+LR
Sbjct: 581 KGSLKMLR 588
>XP_005249633
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  KGSSKLL 7
          KG+SKLL
Sbjct: 76 KGASKLL 82
>XP_006715700
          Length = 765

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>XP_006715699
          Length = 779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>XP_005249632
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>XP_005249631
          Length = 869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>XP_005249630
          Length = 925

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>XP_006715698
          Length = 937

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>XP_006715697
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>XP_005249629
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>XP_006715696
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>XP_005249625
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KGSSKLL 7
           KG+SKLL
Sbjct: 324 KGASKLL 330
>XP_005249005
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGS K+LR
Sbjct: 119 KGSLKMLR 126
>XP_005249004
          Length = 955

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGS K+LR
Sbjct: 597 KGSLKMLR 604
>XP_005249003
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGS K+LR
Sbjct: 575 KGSLKMLR 582
>XP_005249000
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGS K+LR
Sbjct: 597 KGSLKMLR 604
>NP_006531
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KGSSKLLRM 9
           KG +KLL++
Sbjct: 636 KGQTKLLQL 644
>NP_065910
          Length = 1996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KGSSKLLRM 9
           KGS K LR+
Sbjct: 96  KGSYKTLRL 104
>NP_001106205
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KGSSKLLR 8
           +GSS+L+R
Sbjct: 367 RGSSELIR 374
>NP_115883
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KGSSKLLR 8
           KGS+ LLR
Sbjct: 154 KGSNALLR 161
>NP_001159484
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KGSSKLLR 8
           +GSS+L+R
Sbjct: 367 RGSSELIR 374
>NP_001275640
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KGSSKLLR 8
           +GSS+L+R
Sbjct: 180 RGSSELIR 187
>XP_006722435
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KGSSKLLR 8
           +GSS+L+R
Sbjct: 224 RGSSELIR 231
>XP_005258240
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KGSSKLLR 8
           +GSS+L+R
Sbjct: 367 RGSSELIR 374
>XP_006722434
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KGSSKLLR 8
           +GSS+L+R
Sbjct: 367 RGSSELIR 374
>XP_005251190
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KGSSKLLRM 9
           KG +KLL++
Sbjct: 636 KGQTKLLQL 644
>XP_005251188
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KGSSKLLRM 9
           KG +KLL++
Sbjct: 636 KGQTKLLQL 644
>XP_005251189
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KGSSKLLRM 9
           KG +KLL++
Sbjct: 636 KGQTKLLQL 644
>XP_005251187
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KGSSKLLRM 9
           KG +KLL++
Sbjct: 636 KGQTKLLQL 644
>XP_005251186
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KGSSKLLRM 9
           KG +KLL++
Sbjct: 636 KGQTKLLQL 644
>XP_005251185
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KGSSKLLRM 9
           KG +KLL++
Sbjct: 636 KGQTKLLQL 644
>XP_006714345
          Length = 1961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KGSSKLLRM 9
          KGS K LR+
Sbjct: 61 KGSYKTLRL 69
>XP_005263219
          Length = 1996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KGSSKLLRM 9
           KGS K LR+
Sbjct: 96  KGSYKTLRL 104
>XP_005263883
          Length = 189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KGSSKLLR 8
          KGS+ LLR
Sbjct: 52 KGSNALLR 59
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.127    0.313 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 442,976
Number of extensions: 695
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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