Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000590                                                              18    1935
NP_055524                                                              17    2528
NP_065714                                                              17    4312
XP_006720277                                                           17    4312
XP_005271079                                                           17    4312
XP_005271077                                                           17    4312
NP_055204                                                              16    5631
XP_006721566                                                           16    5631
XP_005265948                                                           16    5631
XP_005265947                                                           16    5631
NP_775935                                                              16    5631
NP_001153517                                                           16    7355
NP_005260                                                              16    7355
NP_001161081                                                           16    7355
NP_001229436                                                           16    7355
NP_620714                                                              16    7355
NP_001229435                                                           16    7355
NP_001229434                                                           16    7355
NP_004284                                                              16    7355
XP_005268856                                                           16    7355
XP_006718519                                                           16    7355
XP_006718518                                                           16    7355
XP_006718517                                                           16    7355
XP_006718516                                                           16    7355
XP_005273885                                                           16    7355
XP_005273884                                                           16    7355
XP_005273883                                                           16    7355
XP_005273882                                                           16    7355
XP_006717389                                                           16    7355
XP_005252374                                                           16    7355
NP_004612                                                              15    9605
NP_077270                                                              15    9605
NP_001278147                                                           15    9605
NP_065082                                                              15    9605
NP_001123453                                                           15    9605
NP_001278148                                                           15    9605
NP_940908                                                              15    9605
NP_004854                                                              15    9605
NP_542376                                                              15    9605
NP_004361                                                              15    9605
XP_006726617                                                           15    9605
XP_006720409                                                           15    9605
XP_006718961                                                           15    9605
XP_006715397                                                           15    9605
XP_005249355                                                           15    9605
XP_005263036                                                           15    9605
XP_006710039                                                           15    9605
NP_001004726                                                           15    9605
>NP_000590
          Length = 272

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KFVGGKQN 8
           KFVGG +N
Sbjct: 164 KFVGGAEN 171
>NP_055524
          Length = 3546

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KFVGGKQNL 9
            K +GGK N+
Sbjct: 3100 KLIGGKSNI 3108
>NP_065714
          Length = 214

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VGGKQNL 9
          VGGKQ+L
Sbjct: 64 VGGKQHL 70
>XP_006720277
          Length = 176

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VGGKQNL 9
          VGGKQ+L
Sbjct: 64 VGGKQHL 70
>XP_005271079
          Length = 264

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KFVGGKQN 8
           K V GKQN
Sbjct: 256 KIVSGKQN 263
>XP_005271077
          Length = 305

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KFVGGKQN 8
           K V GKQN
Sbjct: 297 KIVSGKQN 304
>NP_055204
          Length = 1180

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VGGKQNL 9
           VGG QNL
Sbjct: 129 VGGAQNL 135
>XP_006721566
          Length = 1212

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VGGKQNL 9
           VGG QNL
Sbjct: 181 VGGAQNL 187
>XP_005265948
          Length = 273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VGGKQNL 9
           +GG QNL
Sbjct: 129 IGGSQNL 135
>XP_005265947
          Length = 276

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VGGKQNL 9
           +GG QNL
Sbjct: 129 IGGSQNL 135
>NP_775935
          Length = 244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VGGKQNL 9
           +GG QNL
Sbjct: 129 IGGSQNL 135
>NP_001153517
          Length = 978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KFVGGKQ 7
           KF+GG Q
Sbjct: 801 KFLGGSQ 807
>NP_005260
          Length = 1106

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KFVGGKQ 7
           KF+GG Q
Sbjct: 929 KFLGGSQ 935
>NP_001161081
          Length = 1065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KFVGGKQ 7
           KF+GG Q
Sbjct: 888 KFLGGSQ 894
>NP_001229436
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FVGGKQ 7
           +VGGKQ
Sbjct: 367 YVGGKQ 372
>NP_620714
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FVGGKQN 8
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>NP_001229435
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FVGGKQ 7
           +VGGKQ
Sbjct: 367 YVGGKQ 372
>NP_001229434
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FVGGKQ 7
           +VGGKQ
Sbjct: 441 YVGGKQ 446
>NP_004284
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FVGGKQ 7
           +VGGKQ
Sbjct: 441 YVGGKQ 446
>XP_005268856
          Length = 978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KFVGGKQ 7
           KF+GG Q
Sbjct: 801 KFLGGSQ 807
>XP_006718519
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FVGGKQN 8
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_006718518
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  FVGGKQN 8
          F GGKQ+
Sbjct: 38 FAGGKQD 44
>XP_006718517
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FVGGKQN 8
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_006718516
          Length = 566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FVGGKQN 8
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_005273885
          Length = 591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FVGGKQN 8
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_005273884
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FVGGKQN 8
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_005273883
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FVGGKQN 8
           F GGKQ+
Sbjct: 153 FAGGKQD 159
>XP_005273882
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FVGGKQN 8
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_006717389
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FVGGKQ 7
           +VGGKQ
Sbjct: 441 YVGGKQ 446
>XP_005252374
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   FVGGKQ 7
           +VGGKQ
Sbjct: 441 YVGGKQ 446
>NP_004612
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   FVGGKQN 8
           ++G KQN
Sbjct: 659 YIGAKQN 665
>NP_077270
          Length = 298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KFVGGKQ 7
           K+VGG Q
Sbjct: 116 KYVGGDQ 122
>NP_001278147
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VGGKQNL 9
           VGG QNL
Sbjct: 195 VGGIQNL 201
>NP_065082
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VGGKQNL 9
           VGG QNL
Sbjct: 109 VGGIQNL 115
>NP_001123453
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VGGKQNL 9
           VGG QNL
Sbjct: 109 VGGIQNL 115
>NP_001278148
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VGGKQNL 9
           VGG QNL
Sbjct: 195 VGGIQNL 201
>NP_940908
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGKQNL 9
           GGK+NL
Sbjct: 447 GGKRNL 452
>NP_004854
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVGGKQNL 9
           ++GGK+ L
Sbjct: 387 YIGGKKEL 394
>NP_542376
          Length = 1899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   VGGKQN 8
           +GG+QN
Sbjct: 637 IGGRQN 642
>NP_004361
          Length = 3063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    VGGKQN 8
            +GG+QN
Sbjct: 1801 IGGRQN 1806
>XP_006726617
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KFVGGKQN 8
            +F+G KQN
Sbjct: 1527 EFMGHKQN 1534
>XP_006720409
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KFVGGKQN 8
            +F+G KQN
Sbjct: 1527 EFMGHKQN 1534
>XP_006718961
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   FVGGKQN 8
           ++G KQN
Sbjct: 659 YIGAKQN 665
>XP_006715397
          Length = 2972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    VGGKQN 8
            +GG+QN
Sbjct: 1710 IGGRQN 1715
>XP_005249355
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KFVGGKQ 7
           K+VGG Q
Sbjct: 116 KYVGGDQ 122
>XP_005263036
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GGKQNL 9
           GGK+NL
Sbjct: 264 GGKRNL 269
>XP_006710039
          Length = 1584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KFVGGKQN 8
            +F+G KQN
Sbjct: 1423 EFMGHKQN 1430
>NP_001004726
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   KFVGGK 6
           +F+GGK
Sbjct: 298 RFIGGK 303
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.144    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 648,906
Number of extensions: 830
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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