Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              21     229
NP_001035957                                                           21     229
XP_005276506                                                           21     229
XP_006721991                                                           21     229
XP_006721990                                                           21     229
XP_006721989                                                           21     229
XP_005258041                                                           21     229
XP_006721988                                                           21     229
XP_006721987                                                           21     229
XP_006721986                                                           21     229
XP_005258040                                                           21     229
XP_006721985                                                           21     229
XP_006720412                                                           21     229
NP_079027                                                              18    1935
NP_001026890                                                           18    1935
XP_005263279                                                           18    1935
NP_001273903                                                           17    4312
NP_003789                                                              17    4312
XP_006726287                                                           17    4312
XP_005252348                                                           17    4312
NP_878918                                                              16    5631
NP_055995                                                              16    5631
XP_006720147                                                           16    5631
XP_005267517                                                           16    5631
XP_005267516                                                           16    5631
XP_005267515                                                           16    5631
XP_005267514                                                           16    5631
XP_005267513                                                           16    5631
XP_005267512                                                           16    5631
XP_005267511                                                           16    5631
NP_001275676                                                           16    7355
NP_001135935                                                           16    7355
NP_001354                                                              16    7355
NP_116222                                                              16    7355
NP_001185739                                                           16    7355
NP_001070666                                                           16    7355
NP_076990                                                              16    7355
NP_003618                                                              16    7355
XP_005274415                                                           16    7355
XP_005274414                                                           16    7355
XP_005245608                                                           16    7355
NP_003782                                                              15    9605
NP_004573                                                              15    9605
NP_057305                                                              15    9605
NP_473449                                                              15    9605
NP_003282                                                              15    9605
NP_001008781                                                           15    9605
NP_001140201                                                           15    9605
NP_001140200                                                           15    9605
NP_006236                                                              15    9605
NP_851308                                                              15    9605
NP_851307                                                              15    9605
XP_005254129                                                           15    9605
XP_005254128                                                           15    9605
XP_005254127                                                           15    9605
XP_006718827                                                           15    9605
XP_006716982                                                           15    9605
XP_006716981                                                           15    9605
XP_006716980                                                           15    9605
XP_005272572                                                           15    9605
XP_005272573                                                           15    9605
XP_005268514                                                           15    9605
NP_001129115                                                           15    9605
NP_001129116                                                           15    9605
NP_149350                                                              15    9605
>NP_000258
          Length = 2818

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1036 KFRNKMVEY 1044
>NP_001035957
          Length = 2839

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1036 KFRNKMVEY 1044
>XP_005276506
          Length = 151

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  KFSNKMVEY 9
          KF NKMVEY
Sbjct: 69 KFRNKMVEY 77
>XP_006721991
          Length = 1632

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1046 KFRNKMVEY 1054
>XP_006721990
          Length = 2823

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1046 KFRNKMVEY 1054
>XP_006721989
          Length = 2823

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1046 KFRNKMVEY 1054
>XP_005258041
          Length = 2836

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1036 KFRNKMVEY 1044
>XP_006721988
          Length = 2846

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1046 KFRNKMVEY 1054
>XP_006721987
          Length = 2849

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1046 KFRNKMVEY 1054
>XP_006721986
          Length = 2854

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1033 KFRNKMVEY 1041
>XP_005258040
          Length = 2857

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1036 KFRNKMVEY 1044
>XP_006721985
          Length = 2867

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            KF NKMVEY
Sbjct: 1046 KFRNKMVEY 1054
>XP_006720412
          Length = 128

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  KFSNKMVEY 9
          KF NKMVEY
Sbjct: 46 KFRNKMVEY 54
>NP_079027
          Length = 546

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KFSNKMVEY 9
           KFS K+VE+
Sbjct: 217 KFSEKLVEF 225
>NP_001026890
          Length = 633

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KFSNKMVEY 9
           KFS K+VE+
Sbjct: 304 KFSEKLVEF 312
>XP_005263279
          Length = 633

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KFSNKMVEY 9
           KFS K+VE+
Sbjct: 304 KFSEKLVEF 312
>NP_001273903
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFSNKMVEY 9
           +F N+MVE+
Sbjct: 196 QFGNEMVEF 204
>NP_003789
          Length = 734

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFSNKMVEY 9
           +F N+MVE+
Sbjct: 196 QFGNEMVEF 204
>XP_006726287
          Length = 140

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  FSNKMVEY 9
          FSN++V Y
Sbjct: 14 FSNRLVNY 21
>XP_005252348
          Length = 732

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFSNKMVEY 9
           +F N+MVE+
Sbjct: 196 QFGNEMVEF 204
>NP_878918
          Length = 6907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            K+S ++VEY
Sbjct: 2617 KYSQQVVEY 2625
>NP_055995
          Length = 6885

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            K+S ++VEY
Sbjct: 2617 KYSQQVVEY 2625
>XP_006720147
          Length = 4788

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            K+S ++VEY
Sbjct: 2617 KYSQQVVEY 2625
>XP_005267517
          Length = 6883

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            K+S ++VEY
Sbjct: 2617 KYSQQVVEY 2625
>XP_005267516
          Length = 6884

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            K+S ++VEY
Sbjct: 2617 KYSQQVVEY 2625
>XP_005267515
          Length = 6899

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            K+S ++VEY
Sbjct: 2617 KYSQQVVEY 2625
>XP_005267514
          Length = 6908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            K+S ++VEY
Sbjct: 2617 KYSQQVVEY 2625
>XP_005267513
          Length = 6921

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            K+S ++VEY
Sbjct: 2617 KYSQQVVEY 2625
>XP_005267512
          Length = 6922

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            K+S ++VEY
Sbjct: 2617 KYSQQVVEY 2625
>XP_005267511
          Length = 6922

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KFSNKMVEY 9
            K+S ++VEY
Sbjct: 2617 KYSQQVVEY 2625
>NP_001275676
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FSNKMVEY 9
           + +KM+EY
Sbjct: 200 YESKMIEY 207
>NP_001135935
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FSNKMVEY 9
           + +KM+EY
Sbjct: 200 YESKMIEY 207
>NP_001354
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FSNKMVEY 9
           + +KM+EY
Sbjct: 200 YESKMIEY 207
>NP_116222
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   SNKMVEY 9
           SNK+++Y
Sbjct: 422 SNKLIDY 428
>NP_001185739
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NKMVEY 9
           NKM+EY
Sbjct: 326 NKMLEY 331
>NP_001070666
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSNKMVEY 9
           F+NKMV +
Sbjct: 93  FANKMVNH 100
>NP_076990
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FSNKMVEY 9
           F+NKMV +
Sbjct: 93  FANKMVNH 100
>NP_003618
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NKMVEY 9
           NKM+EY
Sbjct: 326 NKMLEY 331
>XP_005274415
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NKMVEY 9
           NKM+EY
Sbjct: 342 NKMLEY 347
>XP_005274414
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NKMVEY 9
           NKM+EY
Sbjct: 352 NKMLEY 357
>XP_005245608
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   SNKMVEY 9
           SNK+++Y
Sbjct: 422 SNKLIDY 428
>NP_003782
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KFSNKMVEY 9
          +FS+ +VEY
Sbjct: 46 EFSSTVVEY 54
>NP_004573
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NKMVEY 9
           NK+VEY
Sbjct: 117 NKVVEY 122
>NP_057305
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   NKMVEY 9
           NK++EY
Sbjct: 145 NKLIEY 150
>NP_473449
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KFSNKMVEY 9
           K  NK+V+Y
Sbjct: 218 KMVNKIVQY 226
>NP_003282
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KFSNKMVE 8
            KF+ K+VE
Sbjct: 1200 KFATKLVE 1207
>NP_001008781
          Length = 4557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    SNKMVEY 9
            +NKMV Y
Sbjct: 2318 NNKMVHY 2324
>NP_001140201
          Length = 269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KFSNKMVEY 9
           K  NK+V+Y
Sbjct: 208 KMVNKIVQY 216
>NP_001140200
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KFSNKMVEY 9
           K  NK+V+Y
Sbjct: 218 KMVNKIVQY 226
>NP_006236
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NKMVEY 9
           N+MVEY
Sbjct: 150 NEMVEY 155
>NP_851308
          Length = 496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NKMVEY 9
          N+MVEY
Sbjct: 44 NEMVEY 49
>NP_851307
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NKMVEY 9
           N+MVEY
Sbjct: 118 NEMVEY 123
>XP_005254129
          Length = 1262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KFSNKMVE 8
            KF+ K+VE
Sbjct: 1213 KFATKLVE 1220
>XP_005254128
          Length = 1291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KFSNKMVE 8
            KF+ K+VE
Sbjct: 1242 KFATKLVE 1249
>XP_005254127
          Length = 1304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KFSNKMVE 8
            KF+ K+VE
Sbjct: 1255 KFATKLVE 1262
>XP_006718827
          Length = 3479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    SNKMVEY 9
            +NKMV Y
Sbjct: 1208 NNKMVHY 1214
>XP_006716982
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KFSNKMVEY 9
           K+S K  EY
Sbjct: 158 KYSRKKTEY 166
>XP_006716981
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KFSNKMVEY 9
           K+S K  EY
Sbjct: 152 KYSRKKTEY 160
>XP_006716980
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KFSNKMVEY 9
           K+S K  EY
Sbjct: 158 KYSRKKTEY 166
>XP_005272572
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KFSNKMVEY 9
           K+S K  EY
Sbjct: 158 KYSRKKTEY 166
>XP_005272573
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KFSNKMVEY 9
           K+S K  EY
Sbjct: 158 KYSRKKTEY 166
>XP_005268514
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4 NKMVEY 9
         NK++EY
Sbjct: 2 NKLIEY 7
>NP_001129115
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   NKMVEY 9
           NK++EY
Sbjct: 145 NKLIEY 150
>NP_001129116
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  NKMVEY 9
          NK++EY
Sbjct: 88 NKLIEY 93
>NP_149350
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KFSNKMVEY 9
           K+S K  EY
Sbjct: 158 KYSRKKTEY 166
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.127    0.342 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 411,893
Number of extensions: 673
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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