Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_006412                                                              18    1935
NP_006411                                                              18    1935
XP_006723746                                                           18    1935
XP_005260309                                                           18    1935
XP_006716481                                                           18    1935
XP_005251193                                                           18    1935
XP_005251192                                                           18    1935
XP_005251191                                                           18    1935
NP_037368                                                              15    9605
NP_001191243                                                           15    9605
NP_000940                                                              15    9605
NP_001191247                                                           15    9605
NP_055177                                                              15    9605
NP_001191245                                                           15    9605
NP_932164                                                              15    9605
NP_001191246                                                           15    9605
NP_001191244                                                           15    9605
NP_958843                                                              15    9605
NP_064620                                                              15    9605
NP_001136040                                                           15    9605
NP_115971                                                              15    9605
XP_006719710                                                           15    9605
XP_006719709                                                           15    9605
XP_006719708                                                           15    9605
XP_006719707                                                           15    9605
XP_006719706                                                           15    9605
XP_006714547                                                           15    9605
XP_006713772                                                           15    9605
XP_006713771                                                           15    9605
XP_005247703                                                           15    9605
XP_006713770                                                           15    9605
XP_006713769                                                           15    9605
XP_005247702                                                           15    9605
XP_005247701                                                           15    9605
XP_005247700                                                           15    9605
XP_005247699                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KENIASSKQ 9
            KEN ASSKQ
Sbjct: 1468 KENTASSKQ 1476
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KENIASSKQ 9
            KEN ASSKQ
Sbjct: 1468 KENTASSKQ 1476
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KENIASSKQ 9
            KEN ASSKQ
Sbjct: 1468 KENTASSKQ 1476
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KENIASSKQ 9
            KEN ASSKQ
Sbjct: 1468 KENTASSKQ 1476
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KENIASSKQ 9
            KEN ASSKQ
Sbjct: 1468 KENTASSKQ 1476
>NP_006412
          Length = 1849

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KENIASSKQ 9
           K+N+AS KQ
Sbjct: 898 KQNVASEKQ 906
>NP_006411
          Length = 1785

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KENIASSKQ 9
           K+N+AS KQ
Sbjct: 843 KQNVASEKQ 851
>XP_006723746
          Length = 1177

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KENIASSKQ 9
           K+N+AS KQ
Sbjct: 235 KQNVASEKQ 243
>XP_005260309
          Length = 1784

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KENIASSKQ 9
           K+N+AS KQ
Sbjct: 842 KQNVASEKQ 850
>XP_006716481
          Length = 1649

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KENIASSKQ 9
           K+N+AS KQ
Sbjct: 698 KQNVASEKQ 706
>XP_005251193
          Length = 1800

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KENIASSKQ 9
           K+N+AS KQ
Sbjct: 898 KQNVASEKQ 906
>XP_005251192
          Length = 1843

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KENIASSKQ 9
           K+N+AS KQ
Sbjct: 898 KQNVASEKQ 906
>XP_005251191
          Length = 1849

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KENIASSKQ 9
           K+N+AS KQ
Sbjct: 898 KQNVASEKQ 906
>NP_037368
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ENIASSKQ 9
          EN+ASS Q
Sbjct: 72 ENLASSLQ 79
>NP_001191243
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 KENIASS 7
         KEN+AS+
Sbjct: 2 KENVASA 8
>NP_000940
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 KENIASS 7
         KEN+AS+
Sbjct: 2 KENVASA 8
>NP_001191247
          Length = 268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 KENIASS 7
         KEN+AS+
Sbjct: 2 KENVASA 8
>NP_055177
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KENIAS 6
           KENIAS
Sbjct: 237 KENIAS 242
>NP_001191245
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 KENIASS 7
         KEN+AS+
Sbjct: 2 KENVASA 8
>NP_932164
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KENIAS 6
           KENIAS
Sbjct: 237 KENIAS 242
>NP_001191246
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 KENIASS 7
         KEN+AS+
Sbjct: 2 KENVASA 8
>NP_001191244
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 KENIASS 7
         KEN+AS+
Sbjct: 2 KENVASA 8
>NP_958843
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   NIASSKQ 9
           NIA SKQ
Sbjct: 269 NIAKSKQ 275
>NP_064620
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
>NP_001136040
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
>NP_115971
          Length = 1604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KENIASSKQ 9
            KEN+ +SK+
Sbjct: 1424 KENLDASKE 1432
>XP_006719710
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   NIASSKQ 9
           NIA SKQ
Sbjct: 108 NIAKSKQ 114
>XP_006719709
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   NIASSKQ 9
           NIA SKQ
Sbjct: 269 NIAKSKQ 275
>XP_006719708
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   NIASSKQ 9
           NIA SKQ
Sbjct: 269 NIAKSKQ 275
>XP_006719707
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   NIASSKQ 9
           NIA SKQ
Sbjct: 269 NIAKSKQ 275
>XP_006719706
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   NIASSKQ 9
           NIA SKQ
Sbjct: 269 NIAKSKQ 275
>XP_006714547
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 KENIASS 7
         KEN+AS+
Sbjct: 2 KENVASA 8
>XP_006713772
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
>XP_006713771
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
>XP_005247703
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
>XP_006713770
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
>XP_006713769
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
>XP_005247702
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
>XP_005247701
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
>XP_005247700
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
>XP_005247699
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KENIASSKQ 9
           KEN+  SK+
Sbjct: 361 KENLRDSKE 369
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.280   0.0975    0.210 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 349,356
Number of extensions: 561
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

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