Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     869
NP_001075109                                                           19     869
XP_005258789                                                           17    4312
NP_055179                                                              17    4312
NP_001165948                                                           16    5631
NP_001182502                                                           16    5631
NP_001258211                                                           16    5631
NP_085124                                                              16    5631
NP_803187                                                              16    5631
NP_001093328                                                           16    5631
XP_005249901                                                           16    5631
NP_076959                                                              16    5631
NP_000384                                                              16    7355
NP_002499                                                              16    7355
XP_006711834                                                           16    7355
NP_001933                                                              15    9605
NP_055994                                                              15    9605
NP_001138586                                                           15    9605
NP_001271266                                                           15    9605
XP_005266332                                                           15    9605

>NP_008835
          Length = 4128

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KELSIGIRG 9
           KELSI IRG
Sbjct: 357 KELSIAIRG 365



>NP_001075109
          Length = 4097

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KELSIGIRG 9
           KELSI IRG
Sbjct: 357 KELSIAIRG 365



>XP_005258789
          Length = 412

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KELSIGIRG 9
          +EL++GI G
Sbjct: 74 RELTVGING 82



>NP_055179
          Length = 408

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KELSIGIRG 9
          +EL++GI G
Sbjct: 74 RELTVGING 82



>NP_001165948
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KELSIGIR 8
          KEL++G+R
Sbjct: 61 KELTLGLR 68



>NP_001182502
          Length = 1829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KELSIGIRG 9
          KELS  IRG
Sbjct: 79 KELSYQIRG 87



>NP_001258211
          Length = 1922

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KELSIGIRG 9
          KELS  IRG
Sbjct: 79 KELSYQIRG 87



>NP_085124
          Length = 1922

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KELSIGIRG 9
          KELS  IRG
Sbjct: 79 KELSYQIRG 87



>NP_803187
          Length = 1922

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KELSIGIRG 9
          KELS  IRG
Sbjct: 79 KELSYQIRG 87



>NP_001093328
          Length = 479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KELSIGIRG 9
           KE+ I +RG
Sbjct: 240 KEMGISVRG 248



>XP_005249901
          Length = 421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KELSIGIRG 9
           KE+ I +RG
Sbjct: 182 KEMGISVRG 190



>NP_076959
          Length = 421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KELSIGIRG 9
           KE+ I +RG
Sbjct: 182 KEMGISVRG 190



>NP_000384
          Length = 1499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SIGIRG 9
           SIGIRG
Sbjct: 604 SIGIRG 609



>NP_002499
          Length = 1247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ELSIGIRG 9
           E SIG RG
Sbjct: 696 ECSIGFRG 703



>XP_006711834
          Length = 1156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ELSIGIRG 9
           E SIG RG
Sbjct: 696 ECSIGFRG 703



>NP_001933
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ELSIGIR 8
           +LSIG+R
Sbjct: 346 QLSIGVR 352



>NP_055994
          Length = 1297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KELSIGIR 8
           KE+S+G R
Sbjct: 867 KEVSVGAR 874



>NP_001138586
          Length = 1236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KELSIGIR 8
           KE+S+G R
Sbjct: 806 KEVSVGAR 813



>NP_001271266
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KELSIGIR 8
           KE+S+G R
Sbjct: 767 KEVSVGAR 774



>XP_005266332
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KELSIGI 7
           K+LS+GI
Sbjct: 406 KQLSVGI 412



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.147    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 432,723
Number of extensions: 721
Number of successful extensions: 20
Number of sequences better than 10000.0: 20
Number of HSP's gapped: 20
Number of HSP's successfully gapped: 20
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)