Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001137236                                                           17    3301
NP_001137235                                                           17    3301
NP_570140                                                              17    3301
NP_001127911                                                           17    4312
NP_001127910                                                           17    4312
NP_665696                                                              17    4312
NP_001127909                                                           17    4312
NP_000305                                                              16    5631
NP_056212                                                              16    5631
XP_006717990                                                           16    5631
XP_006717989                                                           16    5631
NP_001186127                                                           16    7355
NP_060779                                                              16    7355
NP_001172003                                                           16    7355
NP_001171988                                                           16    7355
NP_078893                                                              16    7355
NP_055987                                                              16    7355
NP_660289                                                              16    7355
XP_005269573                                                           16    7355
XP_005269572                                                           16    7355
XP_006717349                                                           16    7355
XP_005252266                                                           16    7355
XP_005252265                                                           16    7355
XP_005252264                                                           16    7355
XP_006717348                                                           16    7355
XP_006717347                                                           16    7355
XP_006717346                                                           16    7355
XP_005245087                                                           16    7355
XP_005245086                                                           16    7355
XP_005245085                                                           16    7355
XP_005245084                                                           16    7355
XP_006711302                                                           16    7355
XP_005245083                                                           16    7355
XP_005245082                                                           16    7355
XP_005245081                                                           16    7355
XP_005245080                                                           16    7355
XP_005245079                                                           16    7355
XP_005245077                                                           16    7355
XP_005245076                                                           16    7355
XP_006711301                                                           16    7355
XP_005245075                                                           16    7355
XP_005245074                                                           16    7355
XP_005245073                                                           16    7355
XP_005245072                                                           16    7355
NP_060628                                                              16    7355
NP_114432                                                              15    9605
NP_006758                                                              15    9605
NP_001770                                                              15    9605
NP_001138294                                                           15    9605
NP_699174                                                              15    9605
XP_006719261                                                           15    9605
NP_006567                                                              15    9605
NP_005870                                                              15    9605
>NP_001137236
          Length = 351

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KEIVSRKQK 9
           KEI+S+KQ+
Sbjct: 99  KEILSKKQE 107
>NP_001137235
          Length = 318

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KEIVSRKQK 9
           KEI+S+KQ+
Sbjct: 99  KEILSKKQE 107
>NP_570140
          Length = 282

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  KEIVSRKQK 9
          KEI+S+KQ+
Sbjct: 63 KEILSKKQE 71
>NP_001127911
          Length = 1253

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           + IVSRK+K
Sbjct: 756 RNIVSRKEK 764
>NP_001127910
          Length = 1253

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           + IVSRK+K
Sbjct: 756 RNIVSRKEK 764
>NP_665696
          Length = 1210

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           + IVSRK+K
Sbjct: 713 RNIVSRKEK 721
>NP_001127909
          Length = 1237

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           + IVSRK+K
Sbjct: 740 RNIVSRKEK 748
>NP_000305
          Length = 403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KEIVSRKQK 9
          KEIVSR ++
Sbjct: 6  KEIVSRNKR 14
>NP_056212
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  KEIVSRKQK 9
          +++VSRK+K
Sbjct: 3  RKVVSRKRK 11
>XP_006717990
          Length = 175

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KEIVSRKQK 9
          KEIVSR ++
Sbjct: 6  KEIVSRNKR 14
>XP_006717989
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KEIVSRKQK 9
          KEIVSR ++
Sbjct: 6  KEIVSRNKR 14
>NP_001186127
          Length = 699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KEIVSRK 7
           +EIVSRK
Sbjct: 621 REIVSRK 627
>NP_060779
          Length = 684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KEIVSRK 7
           +EIVSRK
Sbjct: 606 REIVSRK 612
>NP_001172003
          Length = 1259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KE+VSR+ K
Sbjct: 455 KELVSRELK 463
>NP_001171988
          Length = 1495

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KE+VSR+ K
Sbjct: 578 KELVSRELK 586
>NP_078893
          Length = 1495

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KE+VSR+ K
Sbjct: 578 KELVSRELK 586
>NP_055987
          Length = 2817

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1683 EVVSKKQQ 1690
>NP_660289
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KEI S+K+K
Sbjct: 225 KEIKSKKRK 233
>XP_005269573
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KEI S+K+K
Sbjct: 225 KEIKSKKRK 233
>XP_005269572
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KEI S+K+K
Sbjct: 225 KEIKSKKRK 233
>XP_006717349
          Length = 1046

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KE+VSR+ K
Sbjct: 578 KELVSRELK 586
>XP_005252266
          Length = 1046

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KE+VSR+ K
Sbjct: 578 KELVSRELK 586
>XP_005252265
          Length = 1381

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KE+VSR+ K
Sbjct: 578 KELVSRELK 586
>XP_005252264
          Length = 1478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KE+VSR+ K
Sbjct: 578 KELVSRELK 586
>XP_006717348
          Length = 1541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KE+VSR+ K
Sbjct: 578 KELVSRELK 586
>XP_006717347
          Length = 1541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KE+VSR+ K
Sbjct: 578 KELVSRELK 586
>XP_006717346
          Length = 1541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KE+VSR+ K
Sbjct: 578 KELVSRELK 586
>XP_005245087
          Length = 2708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245086
          Length = 2714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245085
          Length = 2718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245084
          Length = 2719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_006711302
          Length = 2754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245083
          Length = 2774

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245082
          Length = 2779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245081
          Length = 2819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245080
          Length = 2824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245079
          Length = 2838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245077
          Length = 2858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245076
          Length = 2869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_006711301
          Length = 2896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1683 EVVSKKQQ 1690
>XP_005245075
          Length = 2898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1680 EVVSKKQQ 1687
>XP_005245074
          Length = 2898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>XP_005245073
          Length = 2901

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1683 EVVSKKQQ 1690
>XP_005245072
          Length = 2903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EIVSRKQK 9
            E+VS+KQ+
Sbjct: 1685 EVVSKKQQ 1692
>NP_060628
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           +E VSRK+K
Sbjct: 446 QEAVSRKRK 454
>NP_114432
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVSRKQK 9
           I+SRK+K
Sbjct: 962 IISRKEK 968
>NP_006758
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EIVSRKQK 9
           EIV RKQ+
Sbjct: 627 EIVRRKQQ 634
>NP_001770
          Length = 250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KEIVSRKQK 9
          KE++ +KQK
Sbjct: 52 KEVLWKKQK 60
>NP_001138294
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KEIVSRKQK 9
          KE++ +KQK
Sbjct: 52 KEVLWKKQK 60
>NP_699174
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KEIVSRKQK 9
          KEIVSR  K
Sbjct: 51 KEIVSRGVK 59
>XP_006719261
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIVSRKQK 9
           EI+ +KQK
Sbjct: 240 EIIDQKQK 247
>NP_006567
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIVSRKQK 9
           EI+ +KQK
Sbjct: 240 EIIDQKQK 247
>NP_005870
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEIVSRKQK 9
           KEI+S K+K
Sbjct: 262 KEIMSLKKK 270
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.119    0.268 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 478,617
Number of extensions: 1194
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package