Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              19     869
NP_009297                                                              19     869
NP_001035282                                                           18    1482
NP_060303                                                              18    1482
XP_006725461                                                           18    1482
XP_006724090                                                           18    1482
NP_001161710                                                           18    1935
NP_001161709                                                           18    1935
NP_001161708                                                           18    1935
NP_009298                                                              18    1935
NP_005149                                                              18    1935
NP_001161711                                                           18    1935
XP_005245145                                                           18    1935
NP_001129472                                                           18    1935
NP_653082                                                              17    2528
NP_000163                                                              17    2528
NP_001124397                                                           17    4312
NP_055405                                                              17    4312
NP_073617                                                              17    4312
NP_001177766                                                           16    5631
NP_001128512                                                           16    5631
NP_004073                                                              16    5631
NP_075408                                                              16    5631
NP_001128513                                                           16    5631
NP_001177765                                                           16    5631
NP_009203                                                              16    5631
NP_001238892                                                           16    7355
NP_001238891                                                           16    7355
NP_056410                                                              16    7355
NP_001275724                                                           16    7355
NP_001275723                                                           16    7355
NP_001077086                                                           16    7355
NP_073599                                                              16    7355
NP_055596                                                              16    7355
XP_006725061                                                           16    7355
XP_006716556                                                           16    7355
XP_006716555                                                           16    7355
XP_006716554                                                           16    7355
XP_005266029                                                           16    7355
XP_005266028                                                           16    7355
XP_005266026                                                           16    7355
NP_114113                                                              15    9605
NP_055931                                                              15    9605
NP_001157683                                                           15    9605
NP_001157685                                                           15    9605
NP_057090                                                              15    9605
NP_775107                                                              15    9605
NP_056164                                                              15    9605
NP_659415                                                              15    9605
XP_005274116                                                           15    9605
XP_006718652                                                           15    9605
XP_005274115                                                           15    9605
XP_005274114                                                           15    9605
XP_005249030                                                           15    9605
XP_005249029                                                           15    9605
XP_005263951                                                           15    9605
XP_006712408                                                           15    9605
XP_006712407                                                           15    9605
NP_001139669                                                           15    9605
>NP_005148
          Length = 1130

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            KEISD VQR
Sbjct: 1122 KEISDIVQR 1130
>NP_009297
          Length = 1149

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            KEISD VQR
Sbjct: 1141 KEISDIVQR 1149
>NP_001035282
          Length = 388

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KEISDTVQR 9
           KEISDT+++
Sbjct: 261 KEISDTIEQ 269
>NP_060303
          Length = 388

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KEISDTVQR 9
           KEISDT+++
Sbjct: 261 KEISDTIEQ 269
>XP_006725461
          Length = 388

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KEISDTVQR 9
           KEISDT+++
Sbjct: 261 KEISDTIEQ 269
>XP_006724090
          Length = 388

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KEISDTVQR 9
           KEISDT+++
Sbjct: 261 KEISDTIEQ 269
>NP_001161710
          Length = 1058

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            +EISD VQR
Sbjct: 1050 QEISDVVQR 1058
>NP_001161709
          Length = 1079

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            +EISD VQR
Sbjct: 1071 QEISDVVQR 1079
>NP_001161708
          Length = 1161

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            +EISD VQR
Sbjct: 1153 QEISDVVQR 1161
>NP_009298
          Length = 1182

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            +EISD VQR
Sbjct: 1174 QEISDVVQR 1182
>NP_005149
          Length = 1167

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            +EISD VQR
Sbjct: 1159 QEISDVVQR 1167
>NP_001161711
          Length = 1043

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            +EISD VQR
Sbjct: 1035 QEISDVVQR 1043
>XP_005245145
          Length = 1146

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            +EISD VQR
Sbjct: 1138 QEISDVVQR 1146
>NP_001129472
          Length = 1064

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            +EISD VQR
Sbjct: 1056 QEISDVVQR 1064
>NP_653082
          Length = 350

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEISDTVQR 9
           KE+SD +QR
Sbjct: 117 KEMSDIIQR 125
>NP_000163
          Length = 350

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KEISDTVQR 9
           KE+SD +QR
Sbjct: 117 KEMSDIIQR 125
>NP_001124397
          Length = 538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KEISDTVQR 9
           KEI D +QR
Sbjct: 419 KEIRDRIQR 427
>NP_055405
          Length = 538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KEISDTVQR 9
           KEI D +QR
Sbjct: 419 KEIRDRIQR 427
>NP_073617
          Length = 391

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KEISDTVQR 9
          K I DTVQ+
Sbjct: 66 KRIKDTVQK 74
>NP_001177766
          Length = 1271

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            K +SDTV++
Sbjct: 1186 KSLSDTVEK 1194
>NP_001128512
          Length = 1253

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            K +SDTV++
Sbjct: 1168 KSLSDTVEK 1176
>NP_004073
          Length = 1278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            K +SDTV++
Sbjct: 1193 KSLSDTVEK 1201
>NP_075408
          Length = 1144

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            K +SDTV++
Sbjct: 1059 KSLSDTVEK 1067
>NP_001128513
          Length = 1139

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            K +SDTV++
Sbjct: 1054 KSLSDTVEK 1062
>NP_001177765
          Length = 1236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KEISDTVQR 9
            K +SDTV++
Sbjct: 1151 KSLSDTVEK 1159
>NP_009203
          Length = 268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EISDTVQ 8
           E+SDT+Q
Sbjct: 132 ELSDTIQ 138
>NP_001238892
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KEISDTVQR 9
           KE+SDT+ +
Sbjct: 469 KELSDTMTK 477
>NP_001238891
          Length = 871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KEISDTVQR 9
           KE+SDT+ +
Sbjct: 469 KELSDTMTK 477
>NP_056410
          Length = 871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KEISDTVQR 9
           KE+SDT+ +
Sbjct: 469 KELSDTMTK 477
>NP_001275724
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KEISDTVQR 9
          ++I DTVQ+
Sbjct: 53 RKIKDTVQK 61
>NP_001275723
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KEISDTVQR 9
          ++I DTVQ+
Sbjct: 66 RKIKDTVQK 74
>NP_001077086
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KEISDTVQ 8
           KE+ DT+Q
Sbjct: 989 KELEDTLQ 996
>NP_073599
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KEISDTVQR 9
          ++I DTVQ+
Sbjct: 66 RKIKDTVQK 74
>NP_055596
          Length = 1594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KEISDTVQ 8
           KE+ DT+Q
Sbjct: 989 KELEDTLQ 996
>XP_006725061
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KEISDTVQR 9
           KE+SDT+ +
Sbjct: 469 KELSDTMTK 477
>XP_006716556
          Length = 1048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KEISDTVQ 8
           KE+ DT+Q
Sbjct: 446 KELEDTLQ 453
>XP_006716555
          Length = 1539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KEISDTVQ 8
           KE+ DT+Q
Sbjct: 937 KELEDTLQ 944
>XP_006716554
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KEISDTVQ 8
           KE+ DT+Q
Sbjct: 989 KELEDTLQ 996
>XP_005266029
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KEISDTVQR 9
          ++I DTVQ+
Sbjct: 6  RKIKDTVQK 14
>XP_005266028
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KEISDTVQR 9
          ++I DTVQ+
Sbjct: 6  RKIKDTVQK 14
>XP_005266026
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KEISDTVQR 9
          ++I DTVQ+
Sbjct: 66 RKIKDTVQK 74
>NP_114113
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KEISDTVQR 9
           KE+ +T+Q+
Sbjct: 904 KEVEETLQK 912
>NP_055931
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EISDTVQ 8
           ++SDTVQ
Sbjct: 95  DLSDTVQ 101
>NP_001157683
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EISDTVQ 8
           ++SDTVQ
Sbjct: 95  DLSDTVQ 101
>NP_001157685
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EISDTVQ 8
           ++SDTVQ
Sbjct: 95  DLSDTVQ 101
>NP_057090
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   KEISDTV 7
           KEI DTV
Sbjct: 342 KEICDTV 348
>NP_775107
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KEISDTVQR 9
           KE++DT+++
Sbjct: 190 KELNDTLEQ 198
>NP_056164
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KEISDTVQR 9
           + +SD VQR
Sbjct: 724 RSLSDAVQR 732
>NP_659415
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KEISDTVQR 9
           KE++DT+++
Sbjct: 276 KELNDTLKK 284
>XP_005274116
          Length = 1602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EISDTVQR 9
           EIS+TV++
Sbjct: 754 EISETVEK 761
>XP_006718652
          Length = 2196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EISDTVQR 9
            EIS+TV++
Sbjct: 1324 EISETVEK 1331
>XP_005274115
          Length = 2222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EISDTVQR 9
            EIS+TV++
Sbjct: 1350 EISETVEK 1357
>XP_005274114
          Length = 2223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EISDTVQR 9
            EIS+TV++
Sbjct: 1351 EISETVEK 1358
>XP_005249030
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KEISDTVQR 9
           + +SD VQR
Sbjct: 724 RSLSDAVQR 732
>XP_005249029
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KEISDTVQR 9
           + +SD VQR
Sbjct: 724 RSLSDAVQR 732
>XP_005263951
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KEISDTVQR 9
           KE++DT+++
Sbjct: 276 KELNDTLKK 284
>XP_006712408
          Length = 583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KEISDTVQR 9
           KE++DT+++
Sbjct: 282 KELNDTLKK 290
>XP_006712407
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KEISDTVQR 9
           KE++DT+++
Sbjct: 282 KELNDTLKK 290
>NP_001139669
          Length = 7081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    KEISDTVQR 9
            +E+SDT+++
Sbjct: 3889 QELSDTMEK 3897
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.120    0.285 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 440,930
Number of extensions: 859
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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