Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138389                                                           18    1135
NP_001138390                                                           18    1135
NP_001138386                                                           18    1135
NP_001138387                                                           18    1135
NP_000132                                                              18    1135
NP_075259                                                              18    1135
NP_001138388                                                           18    1135
NP_001138391                                                           18    1135
NP_001138385                                                           18    1135
NP_075418                                                              18    1135
XP_006717776                                                           18    1135
XP_006717775                                                           18    1135
XP_006717774                                                           18    1135
XP_006717773                                                           18    1135
XP_006717772                                                           18    1135
XP_006717771                                                           18    1135
NP_004250                                                              17    4312
XP_005257879                                                           17    4312
XP_006722249                                                           17    4312
XP_005257875                                                           17    4312
NP_085152                                                              16    7355
XP_005244773                                                           16    7355
XP_005244772                                                           16    7355
XP_005244771                                                           16    7355
XP_006710392                                                           16    7355
NP_060887                                                              15    9605
XP_005245387                                                           15    9605
XP_005245386                                                           15    9605
XP_006711512                                                           15    9605
>NP_001138389
          Length = 705

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 393 KEAVTVAVK 401
>NP_001138390
          Length = 704

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 392 KEAVTVAVK 400
>NP_001138386
          Length = 709

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 397 KEAVTVAVK 405
>NP_001138387
          Length = 707

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 420 KEAVTVAVK 428
>NP_000132
          Length = 821

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 509 KEAVTVAVK 517
>NP_075259
          Length = 822

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 510 KEAVTVAVK 518
>NP_001138388
          Length = 706

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 394 KEAVTVAVK 402
>NP_001138391
          Length = 680

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 421 KEAVTVAVK 429
>NP_001138385
          Length = 769

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 510 KEAVTVAVK 518
>NP_075418
          Length = 732

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 420 KEAVTVAVK 428
>XP_006717776
          Length = 806

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 528 KEAVTVAVK 536
>XP_006717775
          Length = 726

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 414 KEAVTVAVK 422
>XP_006717774
          Length = 752

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 440 KEAVTVAVK 448
>XP_006717773
          Length = 807

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 529 KEAVTVAVK 537
>XP_006717772
          Length = 838

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 526 KEAVTVAVK 534
>XP_006717771
          Length = 839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KEAVTVVVK 9
           KEAVTV VK
Sbjct: 527 KEAVTVAVK 535
>NP_004250
          Length = 991

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KEAVTVVVK 9
           KEA  VVVK
Sbjct: 913 KEAANVVVK 921
>XP_005257879
          Length = 586

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KEAVTVVVK 9
           KEA  VVVK
Sbjct: 508 KEAANVVVK 516
>XP_006722249
          Length = 607

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KEAVTVVVK 9
           KEA  VVVK
Sbjct: 529 KEAANVVVK 537
>XP_005257875
          Length = 1012

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KEAVTVVVK 9
           KEA  VVVK
Sbjct: 934 KEAANVVVK 942
>NP_085152
          Length = 834

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KEAVTVVV 8
           K+A+TVVV
Sbjct: 305 KDALTVVV 312
>XP_005244773
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KEAVTVVV 8
           K+A+TVVV
Sbjct: 263 KDALTVVV 270
>XP_005244772
          Length = 801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KEAVTVVV 8
           K+A+TVVV
Sbjct: 305 KDALTVVV 312
>XP_005244771
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KEAVTVVV 8
           K+A+TVVV
Sbjct: 273 KDALTVVV 280
>XP_006710392
          Length = 834

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KEAVTVVV 8
           K+A+TVVV
Sbjct: 305 KDALTVVV 312
>NP_060887
          Length = 1610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KEAVTVVVK 9
           K  +TVV+K
Sbjct: 113 KNIITVVIK 121
>XP_005245387
          Length = 1203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KEAVTVVVK 9
           K  +TVV+K
Sbjct: 113 KNIITVVIK 121
>XP_005245386
          Length = 1518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KEAVTVVVK 9
          K  +TVV+K
Sbjct: 21 KNIITVVIK 29
>XP_006711512
          Length = 1547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KEAVTVVVK 9
           K  +TVV+K
Sbjct: 113 KNIITVVIK 121
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.121    0.272 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 233,642
Number of extensions: 223
Number of successful extensions: 29
Number of sequences better than 10000.0: 29
Number of HSP's gapped: 29
Number of HSP's successfully gapped: 29
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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