Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           19     869
NP_055459                                                              19     869
XP_006726410                                                           19     869
XP_006711719                                                           19     869
XP_006711716                                                           19     869
XP_005273038                                                           19     869
XP_006711164                                                           19     869
NP_060802                                                              18    1135
NP_001248344                                                           18    1935
NP_694534                                                              18    1935
NP_008871                                                              18    1935
NP_821078                                                              18    1935
NP_001248343                                                           18    1935
XP_006719213                                                           18    1935
XP_006719212                                                           18    1935
NP_848537                                                              17    4312
NP_113659                                                              17    4312
NP_036256                                                              17    4312
XP_006718768                                                           17    4312
XP_006718767                                                           17    4312
XP_006718766                                                           17    4312
NP_001137545                                                           17    4312
NP_001003937                                                           17    4312
NP_003300                                                              16    5631
NP_065944                                                              16    7355
NP_001245330                                                           16    7355
NP_001035049                                                           16    7355
NP_055336                                                              16    7355
NP_001245331                                                           16    7355
NP_001245332                                                           16    7355
NP_001254544                                                           16    7355
XP_006719764                                                           16    7355
XP_006719763                                                           16    7355
NP_996611                                                              15    9605
NP_001120727                                                           15    9605
NP_631915                                                              15    9605
XP_006726255                                                           15    9605
XP_006726254                                                           15    9605
XP_006726253                                                           15    9605
XP_006726252                                                           15    9605
XP_006726215                                                           15    9605
XP_006726214                                                           15    9605
XP_006726213                                                           15    9605
XP_006726212                                                           15    9605
XP_006726371                                                           15    9605
XP_006726370                                                           15    9605
XP_006726117                                                           15    9605
XP_006726116                                                           15    9605
XP_006726115                                                           15    9605
XP_006726114                                                           15    9605
XP_006726018                                                           15    9605
XP_006726017                                                           15    9605
XP_006726016                                                           15    9605
XP_006726015                                                           15    9605
XP_006725930                                                           15    9605
XP_006725929                                                           15    9605
XP_006725928                                                           15    9605
XP_006725927                                                           15    9605
XP_006725829                                                           15    9605
XP_006725828                                                           15    9605
XP_006725827                                                           15    9605
XP_006725826                                                           15    9605
XP_006725703                                                           15    9605
XP_006725702                                                           15    9605
XP_006725701                                                           15    9605
XP_006725700                                                           15    9605
XP_006725699                                                           15    9605
XP_006726335                                                           15    9605
XP_006726334                                                           15    9605
XP_006726333                                                           15    9605
XP_006726332                                                           15    9605
XP_006723140                                                           15    9605
XP_006723139                                                           15    9605
XP_006723138                                                           15    9605
XP_006723137                                                           15    9605
>NP_001185761
          Length = 2240

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KAMTNLEVK 9
            KA TNLEVK
Sbjct: 2221 KARTNLEVK 2229
>NP_055459
          Length = 2346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KAMTNLEVK 9
            KA TNLEVK
Sbjct: 2327 KARTNLEVK 2335
>XP_006726410
          Length = 2087

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KAMTNLEVK 9
            KA TNLEVK
Sbjct: 2068 KARTNLEVK 2076
>XP_006711719
          Length = 2302

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KAMTNLEVK 9
            KA TNLEVK
Sbjct: 2283 KARTNLEVK 2291
>XP_006711716
          Length = 2411

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KAMTNLEVK 9
            KA TNLEVK
Sbjct: 2392 KARTNLEVK 2400
>XP_005273038
          Length = 2509

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KAMTNLEVK 9
            KA TNLEVK
Sbjct: 2490 KARTNLEVK 2498
>XP_006711164
          Length = 2087

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KAMTNLEVK 9
            KA TNLEVK
Sbjct: 2068 KARTNLEVK 2076
>NP_060802
          Length = 478

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  KAMTNLEVK 9
          K+MTNL++K
Sbjct: 18 KSMTNLQIK 26
>NP_001248344
          Length = 753

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KAMTNLE 7
           KAMTNLE
Sbjct: 585 KAMTNLE 591
>NP_694534
          Length = 750

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KAMTNLE 7
           KAMTNLE
Sbjct: 582 KAMTNLE 588
>NP_008871
          Length = 763

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KAMTNLE 7
           KAMTNLE
Sbjct: 595 KAMTNLE 601
>NP_821078
          Length = 377

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KAMTNLE 7
           KAMTNLE
Sbjct: 209 KAMTNLE 215
>NP_001248343
          Length = 642

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KAMTNLE 7
           KAMTNLE
Sbjct: 474 KAMTNLE 480
>XP_006719213
          Length = 750

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KAMTNLE 7
           KAMTNLE
Sbjct: 582 KAMTNLE 588
>XP_006719212
          Length = 750

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KAMTNLE 7
           KAMTNLE
Sbjct: 582 KAMTNLE 588
>NP_848537
          Length = 667

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AMTNLEVK 9
           A++NLEVK
Sbjct: 326 ALSNLEVK 333
>NP_113659
          Length = 663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AMTNLEVK 9
           A++NLEVK
Sbjct: 326 ALSNLEVK 333
>NP_036256
          Length = 332

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MTNLEVK 9
           MTNLE+K
Sbjct: 115 MTNLELK 121
>XP_006718768
          Length = 483

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AMTNLEVK 9
           A++NLEVK
Sbjct: 146 ALSNLEVK 153
>XP_006718767
          Length = 616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AMTNLEVK 9
           A++NLEVK
Sbjct: 279 ALSNLEVK 286
>XP_006718766
          Length = 663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AMTNLEVK 9
           A++NLEVK
Sbjct: 326 ALSNLEVK 333
>NP_001137545
          Length = 313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MTNLEVK 9
           MTNLE+K
Sbjct: 96  MTNLELK 102
>NP_001003937
          Length = 410

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MTNLEVK 9
           +TNLEVK
Sbjct: 277 LTNLEVK 283
>NP_003300
          Length = 437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MTNLEVK 9
           +TNLEVK
Sbjct: 304 ITNLEVK 310
>NP_065944
          Length = 1701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KAMTNLEVK 9
            + +TNL+VK
Sbjct: 1120 RLLTNLQVK 1128
>NP_001245330
          Length = 1040

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLEVK
Sbjct: 213 TNLEVK 218
>NP_001035049
          Length = 1093

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLEVK
Sbjct: 266 TNLEVK 271
>NP_055336
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   MTNLEVK 9
           MTN EVK
Sbjct: 545 MTNYEVK 551
>NP_001245331
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLEVK
Sbjct: 266 TNLEVK 271
>NP_001245332
          Length = 747

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLEVK
Sbjct: 213 TNLEVK 218
>NP_001254544
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLEVK
Sbjct: 213 TNLEVK 218
>XP_006719764
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLEVK
Sbjct: 266 TNLEVK 271
>XP_006719763
          Length = 800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLEVK
Sbjct: 266 TNLEVK 271
>NP_996611
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 943 TNLEIK 948
>NP_001120727
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>NP_631915
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 972 TNLEIK 977
>XP_006726255
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 970 TNLEIK 975
>XP_006726254
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726253
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726252
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1027 TNLEIK 1032
>XP_006726215
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 970 TNLEIK 975
>XP_006726214
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726213
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726212
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1027 TNLEIK 1032
>XP_006726371
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726370
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726117
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 970 TNLEIK 975
>XP_006726116
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726115
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726114
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1027 TNLEIK 1032
>XP_006726018
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 970 TNLEIK 975
>XP_006726017
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726016
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726015
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1027 TNLEIK 1032
>XP_006725930
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 970 TNLEIK 975
>XP_006725929
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006725928
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006725927
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1027 TNLEIK 1032
>XP_006725829
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 970 TNLEIK 975
>XP_006725828
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006725827
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006725826
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1027 TNLEIK 1032
>XP_006725703
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 943 TNLEIK 948
>XP_006725702
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 970 TNLEIK 975
>XP_006725701
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006725700
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006725699
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1027 TNLEIK 1032
>XP_006726335
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 970 TNLEIK 975
>XP_006726334
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726333
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006726332
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1027 TNLEIK 1032
>XP_006723140
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TNLEVK 9
           TNLE+K
Sbjct: 970 TNLEIK 975
>XP_006723139
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006723138
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1000 TNLEIK 1005
>XP_006723137
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TNLEVK 9
            TNLE+K
Sbjct: 1027 TNLEIK 1032
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.115    0.271 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 306,680
Number of extensions: 448
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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