Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              19     665
NP_001120972                                                           19     665
XP_006716054                                                           19     665
XP_006716053                                                           19     665
XP_006716052                                                           19     665
XP_006716051                                                           19     665
NP_001002811                                                           17    2528
XP_005276195                                                           17    2528
XP_006711712                                                           17    2528
XP_006711711                                                           17    2528
XP_005277503                                                           17    2528
XP_005273038                                                           17    2528
XP_006711708                                                           17    2528
XP_005277500                                                           17    2528
XP_006711707                                                           17    2528
XP_005277499                                                           17    2528
XP_006711706                                                           17    2528
XP_006711705                                                           17    2528
XP_005277559                                                           17    2528
XP_006710144                                                           17    2528
NP_001138397                                                           17    4312
NP_001269849                                                           17    4312
NP_001171517                                                           17    4312
NP_002453                                                              17    4312
XP_005261039                                                           17    4312
XP_005261038                                                           17    4312
XP_005261037                                                           17    4312
XP_005261036                                                           17    4312
XP_005261035                                                           17    4312
XP_006724068                                                           17    4312
NP_001239586                                                           16    5631
XP_006713052                                                           16    5631
XP_006713051                                                           16    5631
NP_003907                                                              16    7355
NP_001259000                                                           16    7355
NP_001034658                                                           16    7355
NP_003874                                                              16    7355
NP_001274                                                              16    7355
NP_001073878                                                           16    7355
XP_005274671                                                           16    7355
XP_005274669                                                           16    7355
XP_006714865                                                           16    7355
NP_036336                                                              16    7355
NP_055426                                                              15    9605
NP_005422                                                              15    9605
XP_006715467                                                           15    9605
>NP_000236
          Length = 1390

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           KAFFMLD I
Sbjct: 818 KAFFMLDGI 826
>NP_001120972
          Length = 1408

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           KAFFMLD I
Sbjct: 836 KAFFMLDGI 844
>XP_006716054
          Length = 960

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           KAFFMLD I
Sbjct: 388 KAFFMLDGI 396
>XP_006716053
          Length = 960

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           KAFFMLD I
Sbjct: 388 KAFFMLDGI 396
>XP_006716052
          Length = 1409

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           KAFFMLD I
Sbjct: 837 KAFFMLDGI 845
>XP_006716051
          Length = 1427

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           KAFFMLD I
Sbjct: 855 KAFFMLDGI 863
>NP_001002811
          Length = 1132

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_005276195
          Length = 381

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_006711712
          Length = 2473

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_006711711
          Length = 2482

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_005277503
          Length = 2498

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_005273038
          Length = 2509

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_006711708
          Length = 2512

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_005277500
          Length = 2525

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_006711707
          Length = 2553

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_005277499
          Length = 2561

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_006711706
          Length = 2591

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_006711705
          Length = 2592

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_005277559
          Length = 381

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>XP_006710144
          Length = 564

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KAFFMLDRI 9
          K  FMLDRI
Sbjct: 53 KCAFMLDRI 61
>NP_001138397
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           K FF++D++
Sbjct: 371 KMFFLIDKV 379
>NP_001269849
          Length = 508

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           K FF++D++
Sbjct: 371 KMFFLIDKV 379
>NP_001171517
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           K FF++D++
Sbjct: 371 KMFFLIDKV 379
>NP_002453
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           K FF++D++
Sbjct: 371 KMFFLIDKV 379
>XP_005261039
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           K FF++D++
Sbjct: 371 KMFFLIDKV 379
>XP_005261038
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           K FF++D++
Sbjct: 371 KMFFLIDKV 379
>XP_005261037
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           K FF++D++
Sbjct: 371 KMFFLIDKV 379
>XP_005261036
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           K FF++D++
Sbjct: 371 KMFFLIDKV 379
>XP_005261035
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           K FF++D++
Sbjct: 371 KMFFLIDKV 379
>XP_006724068
          Length = 685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           K FF++D++
Sbjct: 394 KMFFLIDKV 402
>NP_001239586
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           KAF+ +DR+
Sbjct: 288 KAFWRMDRL 296
>XP_006713052
          Length = 396

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           KAF+ +DR+
Sbjct: 288 KAFWRMDRL 296
>XP_006713051
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           KAF+ +DR+
Sbjct: 288 KAFWRMDRL 296
>NP_003907
          Length = 157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KAFFMLD 7
           KA+F+LD
Sbjct: 108 KAYFILD 114
>NP_001259000
          Length = 160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KAFFMLD 7
           KA+F+LD
Sbjct: 108 KAYFILD 114
>NP_001034658
          Length = 154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KAFFMLD 7
           KA+F+LD
Sbjct: 109 KAYFILD 115
>NP_003874
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           +AF++ DR+
Sbjct: 179 EAFYLTDRV 187
>NP_001274
          Length = 158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KAFFMLD 7
           KA+F+LD
Sbjct: 109 KAYFILD 115
>NP_001073878
          Length = 864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KAFFMLDRI 9
           K+FFML  +
Sbjct: 180 KSFFMLSHL 188
>XP_005274671
          Length = 195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KAFFMLD 7
           KA+F+LD
Sbjct: 150 KAYFILD 156
>XP_005274669
          Length = 202

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KAFFMLD 7
           KA+F+LD
Sbjct: 150 KAYFILD 156
>XP_006714865
          Length = 266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAFFMLDRI 9
           +AF++ DR+
Sbjct: 179 EAFYLTDRV 187
>NP_036336
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FMLDRI 9
           FMLDR+
Sbjct: 145 FMLDRV 150
>NP_055426
          Length = 5596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    FFMLDRI 9
            FF+LD I
Sbjct: 1464 FFLLDEI 1470
>NP_005422
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AFFMLDRI 9
           AF+ +DR+
Sbjct: 153 AFYWIDRV 160
>XP_006715467
          Length = 5550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    FFMLDRI 9
            FF+LD I
Sbjct: 1464 FFLLDEI 1470
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.356    0.161    0.474 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 455,176
Number of extensions: 615
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.0 bits)
S2: 28 (15.4 bits)

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