Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              18    1135
NP_653080                                                              18    1135
XP_005267292                                                           18    1135
XP_005267291                                                           18    1135
XP_005267290                                                           18    1135
NP_002728                                                              17    3301
NP_612412                                                              17    3301
XP_006722035                                                           17    3301
XP_005250751                                                           17    3301
XP_006721807                                                           16    5631
NP_001035758                                                           16    7355
NP_065393                                                              16    7355
NP_997404                                                              16    7355
NP_619580                                                              16    7355
XP_005264491                                                           16    7355
NP_001193928                                                           15    9605
NP_055987                                                              15    9605
NP_005425                                                              15    9605
NP_009105                                                              15    9605
XP_005253886                                                           15    9605
XP_006719269                                                           15    9605
XP_005245087                                                           15    9605
XP_005245086                                                           15    9605
XP_005245085                                                           15    9605
XP_005245084                                                           15    9605
XP_006711302                                                           15    9605
XP_005245083                                                           15    9605
XP_005245082                                                           15    9605
XP_005245081                                                           15    9605
XP_005245080                                                           15    9605
XP_005245079                                                           15    9605
XP_005245077                                                           15    9605
XP_005245076                                                           15    9605
XP_006711301                                                           15    9605
XP_005245075                                                           15    9605
XP_005245074                                                           15    9605
XP_005245073                                                           15    9605
XP_005245072                                                           15    9605
NP_849150                                                              15    9605
>NP_005091
          Length = 1782

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAEVVSEKL 9
           KAEV SEKL
Sbjct: 342 KAEVASEKL 350
>NP_653080
          Length = 1684

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAEVVSEKL 9
           KAEV SEKL
Sbjct: 244 KAEVASEKL 252
>XP_005267292
          Length = 1677

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAEVVSEKL 9
           KAEV SEKL
Sbjct: 237 KAEVASEKL 245
>XP_005267291
          Length = 1684

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAEVVSEKL 9
           KAEV SEKL
Sbjct: 244 KAEVASEKL 252
>XP_005267290
          Length = 1782

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAEVVSEKL 9
           KAEV SEKL
Sbjct: 342 KAEVASEKL 350
>NP_002728
          Length = 672

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KAEVVSEKL 9
           KAEV  EKL
Sbjct: 165 KAEVADEKL 173
>NP_612412
          Length = 226

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KAEVVSEKL 9
           KA+V+ EKL
Sbjct: 175 KADVIKEKL 183
>XP_006722035
          Length = 324

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KAEVVSEKL 9
           KAEV  EKL
Sbjct: 165 KAEVADEKL 173
>XP_005250751
          Length = 147

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KAEVVSEKL 9
           KA+V+ EKL
Sbjct: 96  KADVIKEKL 104
>XP_006721807
          Length = 742

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AEVVSEKL 9
           AE++SEK+
Sbjct: 732 AEIISEKV 739
>NP_001035758
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KAEVVSEKL 9
           +AEV+++KL
Sbjct: 219 EAEVINQKL 227
>NP_065393
          Length = 1192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KAEVVSEK 8
           KA++V+EK
Sbjct: 501 KAQIVTEK 508
>NP_997404
          Length = 986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KAEVVSEK 8
           KA++V+EK
Sbjct: 295 KAQIVTEK 302
>NP_619580
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KAEVVSEKL 9
           +AEV+++KL
Sbjct: 220 EAEVINQKL 228
>XP_005264491
          Length = 986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KAEVVSEK 8
           KA++V+EK
Sbjct: 295 KAQIVTEK 302
>NP_001193928
          Length = 2069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE +S+KL
Sbjct: 1155 KAESLSDKL 1163
>NP_055987
          Length = 2817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1038 KAEKVTEKV 1046
>NP_005425
          Length = 153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AEVVSEKL 9
           A +VSEKL
Sbjct: 113 ATIVSEKL 120
>NP_009105
          Length = 2027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE +S+KL
Sbjct: 1113 KAESLSDKL 1121
>XP_005253886
          Length = 1545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KAEVVSEKL 9
           KAE +S+KL
Sbjct: 647 KAESLSDKL 655
>XP_006719269
          Length = 2054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE +S+KL
Sbjct: 1155 KAESLSDKL 1163
>XP_005245087
          Length = 2708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245086
          Length = 2714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245085
          Length = 2718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245084
          Length = 2719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_006711302
          Length = 2754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245083
          Length = 2774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245082
          Length = 2779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245081
          Length = 2819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245080
          Length = 2824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245079
          Length = 2838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245077
          Length = 2858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245076
          Length = 2869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_006711301
          Length = 2896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1038 KAEKVTEKV 1046
>XP_005245075
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1035 KAEKVTEKV 1043
>XP_005245074
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>XP_005245073
          Length = 2901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1038 KAEKVTEKV 1046
>XP_005245072
          Length = 2903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KAEVVSEKL 9
            KAE V+EK+
Sbjct: 1040 KAEKVTEKV 1048
>NP_849150
          Length = 1445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    KAEVVSE 7
            KA+VVSE
Sbjct: 1093 KAQVVSE 1099
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.294    0.114    0.245 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 376,954
Number of extensions: 632
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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