Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              18    1935
NP_001087241                                                           18    1935
XP_006714101                                                           18    1935
XP_005265799                                                           18    1935
XP_005265798                                                           18    1935
XP_005265797                                                           18    1935
NP_078880                                                              16    7355
NP_001139547                                                           16    7355
NP_001269461                                                           16    7355
NP_056154                                                              16    7355
NP_001269460                                                           16    7355
NP_001139548                                                           16    7355
NP_852107                                                              16    7355
XP_006723822                                                           16    7355
NP_065972                                                              15    9605
NP_001091672                                                           15    9605
XP_005267794                                                           15    9605
XP_005267793                                                           15    9605
XP_005267792                                                           15    9605

>NP_000213
          Length = 976

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KADIMIKSV 9
           KA IMIKSV
Sbjct: 167 KAGIMIKSV 175



>NP_001087241
          Length = 972

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KADIMIKSV 9
           KA IMIKSV
Sbjct: 167 KAGIMIKSV 175



>XP_006714101
          Length = 526

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KADIMIKSV 9
           KA IMIKSV
Sbjct: 167 KAGIMIKSV 175



>XP_005265799
          Length = 973

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KADIMIKSV 9
           KA IMIKSV
Sbjct: 167 KAGIMIKSV 175



>XP_005265798
          Length = 976

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KADIMIKSV 9
           KA IMIKSV
Sbjct: 167 KAGIMIKSV 175



>XP_005265797
          Length = 977

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KADIMIKSV 9
           KA IMIKSV
Sbjct: 167 KAGIMIKSV 175



>NP_078880
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KADIMIKS 8
           +ADI+IKS
Sbjct: 258 EADIVIKS 265



>NP_001139547
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KADIMIKS 8
           +ADI+IKS
Sbjct: 258 EADIVIKS 265



>NP_001269461
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KADIMIKS 8
           KADI +KS
Sbjct: 600 KADIPVKS 607



>NP_056154
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KADIMIKS 8
           KADI +KS
Sbjct: 600 KADIPVKS 607



>NP_001269460
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KADIMIKS 8
           KADI +KS
Sbjct: 600 KADIPVKS 607



>NP_001139548
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KADIMIKS 8
           +ADI+IKS
Sbjct: 99  EADIVIKS 106



>NP_852107
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KADIMIKS 8
           KADI +KS
Sbjct: 600 KADIPVKS 607



>XP_006723822
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KADIMIKS 8
           KADI +KS
Sbjct: 609 KADIPVKS 616



>NP_065972
          Length = 2133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KADIMIKSV 9
            KAD M+K +
Sbjct: 2070 KADAMVKDL 2078



>NP_001091672
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KADIMIKS 8
          +ADI++KS
Sbjct: 5  EADILLKS 12



>XP_005267794
          Length = 1379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KADIMIKSV 9
            KAD M+K +
Sbjct: 1316 KADAMVKDL 1324



>XP_005267793
          Length = 1390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KADIMIKSV 9
            KAD M+K +
Sbjct: 1327 KADAMVKDL 1335



>XP_005267792
          Length = 1420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KADIMIKSV 9
            KAD M+K +
Sbjct: 1357 KADAMVKDL 1365



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.131    0.310 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 271,596
Number of extensions: 367
Number of successful extensions: 19
Number of sequences better than 10000.0: 19
Number of HSP's gapped: 19
Number of HSP's successfully gapped: 19
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)