Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              19     869
NP_116247                                                              18    1935
NP_001273306                                                           18    1935
NP_001273307                                                           18    1935
XP_006711646                                                           18    1935
XP_006711645                                                           18    1935
NP_002290                                                              17    4312
NP_001120936                                                           17    4312
NP_001073882                                                           16    7355
NP_001229854                                                           16    7355
NP_055673                                                              16    7355
NP_056002                                                              16    7355
XP_005273479                                                           16    7355
XP_006714020                                                           16    7355
XP_005248200                                                           16    7355
XP_006714019                                                           16    7355
XP_005245747                                                           16    7355
XP_005245746                                                           16    7355
XP_005245743                                                           16    7355
XP_005245742                                                           16    7355
XP_006711757                                                           16    7355
XP_005245741                                                           16    7355
NP_001165349                                                           15    9605
NP_001165350                                                           15    9605
NP_001186728                                                           15    9605
NP_005360                                                              15    9605
NP_001165347                                                           15    9605
NP_060733                                                              15    9605
NP_001186729                                                           15    9605
NP_787120                                                              15    9605
XP_003960321                                                           15    9605
XP_006724820                                                           15    9605
XP_005262471                                                           15    9605
XP_005262470                                                           15    9605
XP_006713670                                                           15    9605
XP_005247446                                                           15    9605
XP_006713669                                                           15    9605
XP_006712102                                                           15    9605
XP_001718307                                                           15    9605
XP_001715523                                                           15    9605
NP_001165348                                                           15    9605
NP_001093325                                                           15    9605
>NP_005179
          Length = 906

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           KAAS SLHK
Sbjct: 521 KAASGSLHK 529
>NP_116247
          Length = 434

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           +AASDS HK
Sbjct: 172 QAASDSSHK 180
>NP_001273306
          Length = 403

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           +AASDS HK
Sbjct: 141 QAASDSSHK 149
>NP_001273307
          Length = 378

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           +AASDS HK
Sbjct: 116 QAASDSSHK 124
>XP_006711646
          Length = 419

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           +AASDS HK
Sbjct: 157 QAASDSSHK 165
>XP_006711645
          Length = 420

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           +AASDS HK
Sbjct: 158 QAASDSSHK 166
>NP_002290
          Length = 1927

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           + ASDS HK
Sbjct: 427 EVASDSYHK 435
>NP_001120936
          Length = 3925

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SDSLHK 9
           SDSLHK
Sbjct: 369 SDSLHK 374
>NP_001073882
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AASDSLHK 9
           A SDS HK
Sbjct: 473 AGSDSSHK 480
>NP_001229854
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           KAA D LH+
Sbjct: 208 KAAIDHLHQ 216
>NP_055673
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           KAA D LH+
Sbjct: 286 KAAIDHLHQ 294
>NP_056002
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           KAAS  LH+
Sbjct: 756 KAASKGLHQ 764
>XP_005273479
          Length = 265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SDSLHK 9
           SDS+HK
Sbjct: 133 SDSIHK 138
>XP_006714020
          Length = 1097

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           KAAS  LH+
Sbjct: 721 KAASKGLHQ 729
>XP_005248200
          Length = 1103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           KAAS  LH+
Sbjct: 756 KAASKGLHQ 764
>XP_006714019
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           KAAS  LH+
Sbjct: 756 KAASKGLHQ 764
>XP_005245747
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KAASDSLHK 9
          KAA D LH+
Sbjct: 46 KAAIDHLHQ 54
>XP_005245746
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KAASDSLHK 9
          KAA D LH+
Sbjct: 51 KAAIDHLHQ 59
>XP_005245743
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           KAA D LH+
Sbjct: 286 KAAIDHLHQ 294
>XP_005245742
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           KAA D LH+
Sbjct: 208 KAAIDHLHQ 216
>XP_006711757
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           KAA D LH+
Sbjct: 208 KAAIDHLHQ 216
>XP_005245741
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           KAA D LH+
Sbjct: 208 KAAIDHLHQ 216
>NP_001165349
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           K+ +DS+H+
Sbjct: 670 KSVNDSMHQ 678
>NP_001165350
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           K+ +DS+H+
Sbjct: 686 KSVNDSMHQ 694
>NP_001186728
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           +  SDSLH+
Sbjct: 343 RRTSDSLHQ 351
>NP_005360
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           K+ +DS+H+
Sbjct: 670 KSVNDSMHQ 678
>NP_001165347
          Length = 1001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           K+ +DS+H+
Sbjct: 746 KSVNDSMHQ 754
>NP_060733
          Length = 1435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KAASDSL 7
           KAASDS+
Sbjct: 200 KAASDSV 206
>NP_001186729
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           +  SDSLH+
Sbjct: 254 RRTSDSLHQ 262
>NP_787120
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           +  SDSLH+
Sbjct: 299 RRTSDSLHQ 307
>XP_003960321
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           +AAS S HK
Sbjct: 316 RAASHSSHK 324
>XP_006724820
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           K+ +DS+H+
Sbjct: 647 KSVNDSMHQ 655
>XP_005262471
          Length = 1005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           K+ +DS+H+
Sbjct: 815 KSVNDSMHQ 823
>XP_005262470
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           K+ +DS+H+
Sbjct: 789 KSVNDSMHQ 797
>XP_006713670
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           +  SDSLH+
Sbjct: 164 RRTSDSLHQ 172
>XP_005247446
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           +  SDSLH+
Sbjct: 311 RRTSDSLHQ 319
>XP_006713669
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           +  SDSLH+
Sbjct: 341 RRTSDSLHQ 349
>XP_006712102
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  KAASDSL 7
          KAASDS+
Sbjct: 78 KAASDSV 84
>XP_001718307
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           +AAS S HK
Sbjct: 316 RAASHSSHK 324
>XP_001715523
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KAASDSLHK 9
           +AAS S HK
Sbjct: 316 RAASHSSHK 324
>NP_001165348
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           K+ +DS+H+
Sbjct: 631 KSVNDSMHQ 639
>NP_001093325
          Length = 985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KAASDSLHK 9
           K+ +DS+H+
Sbjct: 730 KSVNDSMHQ 738
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.107    0.268 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,623
Number of extensions: 829
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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