Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     390
XP_005266703                                                           20     390
NP_694972                                                              17    4312
NP_795352                                                              17    4312
XP_005266876                                                           17    4312
XP_006715392                                                           17    4312
XP_005266875                                                           17    4312
XP_006710341                                                           17    4312
XP_005270404                                                           17    4312
XP_005270402                                                           17    4312
XP_005270400                                                           17    4312
XP_006710340                                                           17    4312
XP_005270398                                                           17    4312
XP_006710339                                                           17    4312
XP_006710338                                                           17    4312
NP_061063                                                              17    4312
NP_001155899                                                           16    5631
NP_000359                                                              16    5631
NP_001155898                                                           16    5631
NP_006437                                                              16    5631
NP_079350                                                              16    5631
NP_001159605                                                           16    5631
NP_001005283                                                           16    5631
NP_001243241                                                           16    5631
NP_006272                                                              16    5631
NP_001243242                                                           16    5631
XP_006717335                                                           16    5631
XP_006717334                                                           16    5631
XP_005272268                                                           16    5631
XP_005251091                                                           16    5631
XP_006714380                                                           16    5631
XP_006714379                                                           16    5631
XP_006714378                                                           16    5631
XP_006714377                                                           16    5631
NP_000194                                                              16    7355
NP_031392                                                              16    7355
NP_001182570                                                           16    7355
NP_037436                                                              16    7355
NP_004724                                                              16    7355
NP_001177921                                                           16    7355
NP_775820                                                              16    7355
XP_005260493                                                           16    7355
XP_005255972                                                           16    7355
XP_006721248                                                           16    7355
XP_005255971                                                           16    7355
XP_006720939                                                           16    7355
XP_006720938                                                           16    7355
XP_006713945                                                           16    7355
XP_005246452                                                           16    7355
XP_006712432                                                           16    7355
XP_005246450                                                           16    7355
XP_005246449                                                           16    7355
NP_002648                                                              16    7355
NP_036599                                                              16    7355
NP_001360                                                              15    9605
NP_006601                                                              15    9605
NP_000646                                                              15    9605
NP_116166                                                              15    9605
NP_065910                                                              15    9605
NP_055524                                                              15    9605
XP_006722696                                                           15    9605
XP_006720070                                                           15    9605
XP_005273528                                                           15    9605
XP_006716388                                                           15    9605
XP_005248319                                                           15    9605
XP_005263222                                                           15    9605
XP_005263221                                                           15    9605
XP_005263220                                                           15    9605
XP_006714345                                                           15    9605
XP_005263219                                                           15    9605
>NP_443179
          Length = 2170

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IYTAEAQPL 9
            IY AEAQPL
Sbjct: 1994 IYAAEAQPL 2002
>XP_005266703
          Length = 1501

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IYTAEAQPL 9
            IY AEAQPL
Sbjct: 1325 IYAAEAQPL 1333
>NP_694972
          Length = 1330

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IYTAEAQP 8
           IYT E QP
Sbjct: 305 IYTDETQP 312
>NP_795352
          Length = 1801

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           +Y+ EAQP
Sbjct: 930 VYSQEAQP 937
>XP_005266876
          Length = 321

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TAEAQPL 9
          T+EAQPL
Sbjct: 14 TSEAQPL 20
>XP_006715392
          Length = 325

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TAEAQPL 9
          T+EAQPL
Sbjct: 14 TSEAQPL 20
>XP_005266875
          Length = 454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TAEAQPL 9
          T+EAQPL
Sbjct: 14 TSEAQPL 20
>XP_006710341
          Length = 1296

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           +Y+ EAQP
Sbjct: 930 VYSQEAQP 937
>XP_005270404
          Length = 1300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           +Y+ EAQP
Sbjct: 930 VYSQEAQP 937
>XP_005270402
          Length = 1454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           +Y+ EAQP
Sbjct: 930 VYSQEAQP 937
>XP_005270400
          Length = 1668

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           +Y+ EAQP
Sbjct: 930 VYSQEAQP 937
>XP_006710340
          Length = 1815

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           +Y+ EAQP
Sbjct: 930 VYSQEAQP 937
>XP_005270398
          Length = 1882

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           +Y+ EAQP
Sbjct: 930 VYSQEAQP 937
>XP_006710339
          Length = 1896

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           +Y+ EAQP
Sbjct: 930 VYSQEAQP 937
>XP_006710338
          Length = 1896

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           +Y+ EAQP
Sbjct: 930 VYSQEAQP 937
>NP_061063
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TAEAQPL 9
          T+EAQPL
Sbjct: 14 TSEAQPL 20
>NP_001155899
          Length = 1113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYTAEAQPL 9
           I TAEA+P+
Sbjct: 438 ITTAEAEPV 446
>NP_000359
          Length = 1164

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYTAEAQPL 9
           I TAEA+P+
Sbjct: 489 ITTAEAEPV 497
>NP_001155898
          Length = 1163

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYTAEAQPL 9
           I TAEA+P+
Sbjct: 488 ITTAEAEPV 496
>NP_006437
          Length = 691

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  TAEAQP 8
          TAEAQP
Sbjct: 10 TAEAQP 15
>NP_079350
          Length = 4012

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YTAEAQPL 9
           +TA+ QPL
Sbjct: 190 FTAQCQPL 197
>NP_001159605
          Length = 1976

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YTAEAQPL 9
           +TA+ QPL
Sbjct: 190 FTAQCQPL 197
>NP_001005283
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTAEAQPL 9
           YTA  QPL
Sbjct: 123 YTAVCQPL 130
>NP_001243241
          Length = 519

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YTAEAQPL 9
           YTA+ QP+
Sbjct: 498 YTAKRQPI 505
>NP_006272
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YTAEAQPL 9
           YTA+ QP+
Sbjct: 470 YTAKRQPI 477
>NP_001243242
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YTAEAQPL 9
           YTA+ QP+
Sbjct: 359 YTAKRQPI 366
>XP_006717335
          Length = 667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYTAEAQPL 9
           I TAEA+P+
Sbjct: 489 ITTAEAEPV 497
>XP_006717334
          Length = 1164

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYTAEAQPL 9
           I TAEA+P+
Sbjct: 489 ITTAEAEPV 497
>XP_005272268
          Length = 1164

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYTAEAQPL 9
           I TAEA+P+
Sbjct: 489 ITTAEAEPV 497
>XP_005251091
          Length = 260

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YTAEAQPL 9
           YTA+ QP+
Sbjct: 239 YTAKRQPI 246
>XP_006714380
          Length = 3897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YTAEAQPL 9
           +TA+ QPL
Sbjct: 190 FTAQCQPL 197
>XP_006714379
          Length = 3936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YTAEAQPL 9
           +TA+ QPL
Sbjct: 190 FTAQCQPL 197
>XP_006714378
          Length = 3965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YTAEAQPL 9
           +TA+ QPL
Sbjct: 190 FTAQCQPL 197
>XP_006714377
          Length = 4010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YTAEAQPL 9
           +TA+ QPL
Sbjct: 190 FTAQCQPL 197
>NP_000194
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IYTAEAQPL 9
           IY  EA PL
Sbjct: 295 IYNDEADPL 303
>NP_031392
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    IYTAEAQP 8
            I+TAEA P
Sbjct: 1383 IHTAEALP 1390
>NP_001182570
          Length = 1461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    IYTAEAQP 8
            I+TAEA P
Sbjct: 1381 IHTAEALP 1388
>NP_037436
          Length = 485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IYTAEAQP 8
          ++TA AQP
Sbjct: 20 VWTAPAQP 27
>NP_004724
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTAEAQPL 9
           YTA  QPL
Sbjct: 366 YTAGPQPL 373
>NP_001177921
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YTAEAQPL 9
           YTA  QPL
Sbjct: 366 YTAGPQPL 373
>NP_775820
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AEAQPL 9
           AEAQPL
Sbjct: 147 AEAQPL 152
>XP_005260493
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AEAQPL 9
           AEAQPL
Sbjct: 444 AEAQPL 449
>XP_005255972
          Length = 356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IYTAEAQP 8
          ++TA AQP
Sbjct: 20 VWTAPAQP 27
>XP_006721248
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IYTAEAQP 8
          ++TA AQP
Sbjct: 20 VWTAPAQP 27
>XP_005255971
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IYTAEAQP 8
          ++TA AQP
Sbjct: 20 VWTAPAQP 27
>XP_006720939
          Length = 346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YTAEAQPL 9
           YT E +PL
Sbjct: 191 YTREGEPL 198
>XP_006720938
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YTAEAQPL 9
           YT E +PL
Sbjct: 191 YTREGEPL 198
>XP_006713945
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IYTAEAQPL 9
           IY  EA PL
Sbjct: 163 IYNDEADPL 171
>XP_005246452
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           I+TAEA P
Sbjct: 696 IHTAEALP 703
>XP_006712432
          Length = 786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IYTAEAQP 8
           I+TAEA P
Sbjct: 706 IHTAEALP 713
>XP_005246450
          Length = 1461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    IYTAEAQP 8
            I+TAEA P
Sbjct: 1381 IHTAEALP 1388
>XP_005246449
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    IYTAEAQP 8
            I+TAEA P
Sbjct: 1383 IHTAEALP 1390
>NP_002648
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AEAQPL 9
           AEAQPL
Sbjct: 444 AEAQPL 449
>NP_036599
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YTAEAQPL 9
           YT E +PL
Sbjct: 166 YTREGEPL 173
>NP_001360
          Length = 4624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TAEAQPL 9
           TAEA+P+
Sbjct: 653 TAEAKPI 659
>NP_006601
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YTAEAQP 8
           YT+ AQP
Sbjct: 293 YTSTAQP 299
>NP_000646
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   YTAEAQP 8
           YTA  QP
Sbjct: 169 YTASCQP 175
>NP_116166
          Length = 1338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IYTAEA 6
           +YTAEA
Sbjct: 449 VYTAEA 454
>NP_065910
          Length = 1996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YTAEAQP 8
           YT +AQP
Sbjct: 452 YTQKAQP 458
>NP_055524
          Length = 3546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    YTAEAQPL 9
            YT + QPL
Sbjct: 1964 YTMDKQPL 1971
>XP_006722696
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IYTAEAQPL 9
           +YT+  +PL
Sbjct: 562 VYTSSTRPL 570
>XP_006720070
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IYTAEAQP 8
          + TAEA+P
Sbjct: 12 VSTAEAEP 19
>XP_005273528
          Length = 813

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IYTAEA 6
           +YTAEA
Sbjct: 449 VYTAEA 454
>XP_006716388
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IYTAEA 6
           +YTAEA
Sbjct: 425 VYTAEA 430
>XP_005248319
          Length = 4609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TAEAQPL 9
           TAEA+P+
Sbjct: 638 TAEAKPI 644
>XP_005263222
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YTAEAQP 8
           YT +AQP
Sbjct: 276 YTQKAQP 282
>XP_005263221
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YTAEAQP 8
           YT +AQP
Sbjct: 276 YTQKAQP 282
>XP_005263220
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YTAEAQP 8
           YT +AQP
Sbjct: 276 YTQKAQP 282
>XP_006714345
          Length = 1961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YTAEAQP 8
           YT +AQP
Sbjct: 417 YTQKAQP 423
>XP_005263219
          Length = 1996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YTAEAQP 8
           YT +AQP
Sbjct: 452 YTQKAQP 458
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.128    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 628,065
Number of extensions: 1212
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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