Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055726                                                              20     299
NP_060063                                                              18    1935
NP_942595                                                              18    1935
XP_005263174                                                           18    1935
NP_001245308                                                           17    3301
NP_003606                                                              17    3301
NP_001245309                                                           17    3301
NP_066015                                                              17    3301
XP_005258381                                                           17    3301
XP_006722580                                                           17    3301
XP_006722579                                                           17    3301
XP_005258380                                                           17    3301
XP_005265658                                                           17    3301
XP_005265657                                                           17    3301
XP_005265656                                                           17    3301
XP_005265655                                                           17    3301
XP_006713484                                                           17    3301
NP_005914                                                              17    4312
NP_055845                                                              17    4312
XP_005267049                                                           17    4312
XP_006715545                                                           17    4312
XP_005267048                                                           17    4312
XP_005248150                                                           17    4312
XP_005248148                                                           17    4312
XP_005248147                                                           17    4312
XP_005248146                                                           17    4312
XP_005248145                                                           17    4312
XP_005248144                                                           17    4312
XP_005248143                                                           17    4312
XP_005248142                                                           17    4312
XP_005248141                                                           17    4312
XP_005248140                                                           17    4312
XP_005248139                                                           17    4312
NP_002435                                                              16    5631
NP_001829                                                              16    5631
NP_001193900                                                           16    5631
NP_002828                                                              16    5631
NP_001103224                                                           16    5631
NP_001193901                                                           16    5631
XP_005262326                                                           16    5631
XP_006719592                                                           16    5631
XP_006719591                                                           16    5631
XP_005247894                                                           16    5631
NP_006013                                                              16    7355
NP_001265546                                                           16    7355
NP_001265545                                                           16    7355
NP_004327                                                              16    7355
NP_055523                                                              16    7355
NP_079199                                                              16    7355
XP_005276759                                                           16    7355
XP_005276750                                                           16    7355
XP_003846353                                                           16    7355
XP_003846349                                                           16    7355
XP_006719769                                                           16    7355
XP_003960959                                                           16    7355
NP_001143                                                              15    9605
NP_061893                                                              15    9605
NP_008970                                                              15    9605
NP_001258773                                                           15    9605
NP_001258774                                                           15    9605
XP_005257107                                                           15    9605
XP_006721757                                                           15    9605
XP_005257106                                                           15    9605
XP_005267344                                                           15    9605
NP_112581                                                              15    9605
>NP_055726
          Length = 961

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   IYQVSYFS 8
           IYQVSYFS
Sbjct: 304 IYQVSYFS 311
>NP_060063
          Length = 662

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   IYQVSYFS 8
           I+QVSYF+
Sbjct: 308 IFQVSYFA 315
>NP_942595
          Length = 1161

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   IYQVSYFS 8
           I+QVSYF+
Sbjct: 308 IFQVSYFA 315
>XP_005263174
          Length = 1124

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   IYQVSYFS 8
           I+QVSYF+
Sbjct: 308 IFQVSYFA 315
>NP_001245308
          Length = 1131

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQVSYFSL 9
           YQ+SY SL
Sbjct: 566 YQLSYLSL 573
>NP_003606
          Length = 1214

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQVSYFSL 9
           YQ+SY SL
Sbjct: 685 YQLSYLSL 692
>NP_001245309
          Length = 1090

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQVSYFSL 9
           YQ+SY SL
Sbjct: 561 YQLSYLSL 568
>NP_066015
          Length = 2579

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           IY+VSY +L
Sbjct: 802 IYEVSYVTL 810
>XP_005258381
          Length = 2224

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           IY+VSY +L
Sbjct: 447 IYEVSYVTL 455
>XP_006722580
          Length = 2532

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           IY+VSY +L
Sbjct: 802 IYEVSYVTL 810
>XP_006722579
          Length = 2544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           IY+VSY +L
Sbjct: 802 IYEVSYVTL 810
>XP_005258380
          Length = 2578

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           IY+VSY +L
Sbjct: 802 IYEVSYVTL 810
>XP_005265658
          Length = 1095

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQVSYFSL 9
           YQ+SY SL
Sbjct: 566 YQLSYLSL 573
>XP_005265657
          Length = 1113

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQVSYFSL 9
           YQ+SY SL
Sbjct: 548 YQLSYLSL 555
>XP_005265656
          Length = 1118

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQVSYFSL 9
           YQ+SY SL
Sbjct: 553 YQLSYLSL 560
>XP_005265655
          Length = 1126

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQVSYFSL 9
           YQ+SY SL
Sbjct: 561 YQLSYLSL 568
>XP_006713484
          Length = 1255

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQVSYFSL 9
           YQ+SY SL
Sbjct: 690 YQLSYLSL 697
>NP_005914
          Length = 1374

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYQVSYFSL 9
           IYQ SY S+
Sbjct: 569 IYQPSYLSI 577
>NP_055845
          Length = 3013

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1263 LYSVSYYQL 1271
>XP_005267049
          Length = 808

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYQVSYFSL 9
           IYQ SY S+
Sbjct: 678 IYQPSYLSI 686
>XP_006715545
          Length = 1483

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYQVSYFSL 9
           IYQ SY S+
Sbjct: 678 IYQPSYLSI 686
>XP_005267048
          Length = 1484

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYQVSYFSL 9
           IYQ SY S+
Sbjct: 678 IYQPSYLSI 686
>XP_005248150
          Length = 2044

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IYQVSYFSL 9
           +Y VSY+ L
Sbjct: 294 LYSVSYYQL 302
>XP_005248148
          Length = 3028

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1278 LYSVSYYQL 1286
>XP_005248147
          Length = 3028

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1278 LYSVSYYQL 1286
>XP_005248146
          Length = 3073

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1370 LYSVSYYQL 1378
>XP_005248145
          Length = 3079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1329 LYSVSYYQL 1337
>XP_005248144
          Length = 3099

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1355 LYSVSYYQL 1363
>XP_005248143
          Length = 3105

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1355 LYSVSYYQL 1363
>XP_005248142
          Length = 3114

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1370 LYSVSYYQL 1378
>XP_005248141
          Length = 3119

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1370 LYSVSYYQL 1378
>XP_005248140
          Length = 3119

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1369 LYSVSYYQL 1377
>XP_005248139
          Length = 3120

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IYQVSYFSL 9
            +Y VSY+ L
Sbjct: 1370 LYSVSYYQL 1378
>NP_002435
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           +Y V+YFS+
Sbjct: 200 MYGVNYFSI 208
>NP_001829
          Length = 378

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IYQVSYFS 8
           IY++S+FS
Sbjct: 135 IYKMSFFS 142
>NP_001193900
          Length = 1907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    IYQVSYFS 8
            +YQ +YF+
Sbjct: 1433 VYQTNYFA 1440
>NP_002828
          Length = 1997

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    IYQVSYFS 8
            +YQ +YF+
Sbjct: 1523 VYQTNYFA 1530
>NP_001103224
          Length = 2215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    IYQVSYFS 8
            +YQ +YF+
Sbjct: 1741 VYQTNYFA 1748
>NP_001193901
          Length = 1907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    IYQVSYFS 8
            +YQ +YF+
Sbjct: 1433 VYQTNYFA 1440
>XP_005262326
          Length = 578

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           +Y V+YFS+
Sbjct: 201 MYGVNYFSI 209
>XP_006719592
          Length = 2012

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    IYQVSYFS 8
            +YQ +YF+
Sbjct: 1523 VYQTNYFA 1530
>XP_006719591
          Length = 2230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    IYQVSYFS 8
            +YQ +YF+
Sbjct: 1741 VYQTNYFA 1748
>XP_005247894
          Length = 917

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 IYQVSYFS 8
         +YQVSY S
Sbjct: 1 MYQVSYAS 8
>NP_006013
          Length = 144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  IYQVSYFSL 9
          +YQ+ +FS+
Sbjct: 15 VYQLRHFSI 23
>NP_001265546
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   YQVSYFSL 9
           YQ+ YF +
Sbjct: 927 YQIDYFGV 934
>NP_001265545
          Length = 1065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   YQVSYFSL 9
           YQ+ YF +
Sbjct: 964 YQIDYFGV 971
>NP_004327
          Length = 1085

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   YQVSYFSL 9
           YQ+ YF +
Sbjct: 984 YQIDYFGV 991
>NP_055523
          Length = 2209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    IYQVSYFS 8
            ++QV YFS
Sbjct: 2008 LWQVPYFS 2015
>NP_079199
          Length = 1887

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YQVSYFSL 9
            YQV +F+L
Sbjct: 1807 YQVMFFTL 1814
>XP_005276759
          Length = 160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           ++ +SYFS+
Sbjct: 125 VFYLSYFSI 133
>XP_005276750
          Length = 160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           ++ +SYFS+
Sbjct: 125 VFYLSYFSI 133
>XP_003846353
          Length = 160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           ++ +SYFS+
Sbjct: 125 VFYLSYFSI 133
>XP_003846349
          Length = 160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           ++ +SYFS+
Sbjct: 125 VFYLSYFSI 133
>XP_006719769
          Length = 2209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    IYQVSYFS 8
            ++QV YFS
Sbjct: 2008 LWQVPYFS 2015
>XP_003960959
          Length = 160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IYQVSYFSL 9
           ++ +SYFS+
Sbjct: 125 VFYLSYFSI 133
>NP_001143
          Length = 298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IYQVSYFSL 9
           IY+ +YF +
Sbjct: 186 IYRAAYFGI 194
>NP_061893
          Length = 767

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YQVSYFSL 9
           YQ  YF L
Sbjct: 635 YQTDYFHL 642
>NP_008970
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QVSYFSL 9
          +V+YFSL
Sbjct: 60 EVTYFSL 66
>NP_001258773
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YQVSYFSL 9
           YQ  YF L
Sbjct: 260 YQTDYFHL 267
>NP_001258774
          Length = 405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YQVSYFSL 9
           YQ  YF L
Sbjct: 273 YQTDYFHL 280
>XP_005257107
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YQVSYFSL 9
           YQ  YF L
Sbjct: 634 YQTDYFHL 641
>XP_006721757
          Length = 767

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YQVSYFSL 9
           YQ  YF L
Sbjct: 635 YQTDYFHL 642
>XP_005257106
          Length = 767

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   YQVSYFSL 9
           YQ  YF L
Sbjct: 635 YQTDYFHL 642
>XP_005267344
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QVSYFSL 9
          +V+YFSL
Sbjct: 60 EVTYFSL 66
>NP_112581
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   IYQVSYF 7
           +Y+ SYF
Sbjct: 198 VYRASYF 204
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.144    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 490,938
Number of extensions: 836
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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