Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           19     665
NP_071754                                                              19     665
NP_001185763                                                           19     665
NP_001002810                                                           19     665
NP_055459                                                              19     665
NP_001182189                                                           19     665
NP_001002812                                                           19     665
NP_001182190                                                           19     665
XP_006711719                                                           19     665
XP_006711717                                                           19     665
XP_006711716                                                           19     665
XP_006711715                                                           19     665
XP_006711714                                                           19     665
XP_006711713                                                           19     665
XP_006711710                                                           19     665
XP_006711709                                                           19     665
NP_001273589                                                           17    4312
NP_001273586                                                           17    4312
NP_689630                                                              17    4312
XP_006716482                                                           17    4312
XP_005251207                                                           17    4312
NP_690042                                                              16    5631
NP_056456                                                              16    5631
NP_775834                                                              16    5631
NP_036548                                                              16    5631
XP_005250315                                                           16    5631
XP_006715090                                                           16    5631
XP_006715089                                                           16    5631
XP_006715088                                                           16    5631
XP_005249008                                                           16    5631
NP_001139182                                                           16    7355
NP_055693                                                              16    7355
XP_006723127                                                           16    7355
NP_689816                                                              16    7355
NP_001124295                                                           15    9605
NP_001370                                                              15    9605
NP_001276081                                                           15    9605
NP_001170990                                                           15    9605
NP_001276082                                                           15    9605
NP_001276083                                                           15    9605
NP_775966                                                              15    9605
NP_060191                                                              15    9605
NP_055907                                                              15    9605
XP_005260032                                                           15    9605
XP_005260031                                                           15    9605
XP_005260030                                                           15    9605
XP_005260029                                                           15    9605
XP_006722744                                                           15    9605
XP_005255242                                                           15    9605
XP_005255241                                                           15    9605
XP_005255240                                                           15    9605
XP_005255239                                                           15    9605
>NP_001185761
          Length = 2240

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IYKRNIVLK 9
           IYKRNI LK
Sbjct: 110 IYKRNIELK 118
>NP_071754
          Length = 310

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IYKRNIVLK 9
           IYKRNI LK
Sbjct: 181 IYKRNIELK 189
>NP_001185763
          Length = 2362

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  IYKRNIVLK 9
          IYKRNI LK
Sbjct: 44 IYKRNIELK 52
>NP_001002810
          Length = 173

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  IYKRNIVLK 9
          IYKRNI LK
Sbjct: 44 IYKRNIELK 52
>NP_055459
          Length = 2346

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  IYKRNIVLK 9
          IYKRNI LK
Sbjct: 44 IYKRNIELK 52
>NP_001182189
          Length = 141

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  IYKRNIVLK 9
          IYKRNI LK
Sbjct: 12 IYKRNIELK 20
>NP_001002812
          Length = 969

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  IYKRNIVLK 9
          IYKRNI LK
Sbjct: 44 IYKRNIELK 52
>NP_001182190
          Length = 176

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  IYKRNIVLK 9
          IYKRNI LK
Sbjct: 47 IYKRNIELK 55
>XP_006711719
          Length = 2302

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IYKRNIVLK 9
           IYKRNI LK
Sbjct: 110 IYKRNIELK 118
>XP_006711717
          Length = 2385

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IYKRNIVLK 9
           IYKRNI LK
Sbjct: 110 IYKRNIELK 118
>XP_006711716
          Length = 2411

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IYKRNIVLK 9
           IYKRNI LK
Sbjct: 110 IYKRNIELK 118
>XP_006711715
          Length = 2428

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  IYKRNIVLK 9
          IYKRNI LK
Sbjct: 44 IYKRNIELK 52
>XP_006711714
          Length = 2429

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  IYKRNIVLK 9
          IYKRNI LK
Sbjct: 44 IYKRNIELK 52
>XP_006711713
          Length = 2432

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  IYKRNIVLK 9
          IYKRNI LK
Sbjct: 47 IYKRNIELK 55
>XP_006711710
          Length = 2494

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IYKRNIVLK 9
           IYKRNI LK
Sbjct: 110 IYKRNIELK 118
>XP_006711709
          Length = 2495

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IYKRNIVLK 9
           IYKRNI LK
Sbjct: 110 IYKRNIELK 118
>NP_001273589
          Length = 135

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  IYKRNIVLK 9
          IYKR  VLK
Sbjct: 73 IYKRKNVLK 81
>NP_001273586
          Length = 324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  IYKRNIVLK 9
          IYKR  VLK
Sbjct: 73 IYKRKNVLK 81
>NP_689630
          Length = 257

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  IYKRNIVLK 9
          IYKR  VLK
Sbjct: 73 IYKRKNVLK 81
>XP_006716482
          Length = 324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  IYKRNIVLK 9
          IYKR  VLK
Sbjct: 73 IYKRKNVLK 81
>XP_005251207
          Length = 324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  IYKRNIVLK 9
          IYKR  VLK
Sbjct: 73 IYKRKNVLK 81
>NP_690042
          Length = 412

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  IYKRNIVL 8
          +YKRN+++
Sbjct: 77 MYKRNVMI 84
>NP_056456
          Length = 421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  IYKRNIVL 8
          +YKRN+++
Sbjct: 86 MYKRNVMI 93
>NP_775834
          Length = 508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IYKRNIVL 8
           +Y++NIVL
Sbjct: 472 LYRQNIVL 479
>NP_036548
          Length = 1105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYKRNIVL 8
           IY +N+VL
Sbjct: 148 IYSKNVVL 155
>XP_005250315
          Length = 336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1 IYKRNIVL 8
         +YKRN+++
Sbjct: 1 MYKRNVMI 8
>XP_006715090
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IYKRNIVL 8
           +Y++NIVL
Sbjct: 316 LYRQNIVL 323
>XP_006715089
          Length = 445

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IYKRNIVL 8
           +Y++NIVL
Sbjct: 409 LYRQNIVL 416
>XP_006715088
          Length = 445

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IYKRNIVL 8
           +Y++NIVL
Sbjct: 409 LYRQNIVL 416
>XP_005249008
          Length = 499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IYKRNIVL 8
           +Y++NIVL
Sbjct: 463 LYRQNIVL 470
>NP_001139182
          Length = 324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IYKRNIVLK 9
          +YK N V+K
Sbjct: 48 LYKENSVIK 56
>NP_055693
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   YKRNIVLK 9
           Y RNIV K
Sbjct: 214 YSRNIVKK 221
>XP_006723127
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   YKRNIVL 8
           YKRN+++
Sbjct: 628 YKRNLIV 634
>NP_689816
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   YKRNIVL 8
           YKRN+++
Sbjct: 597 YKRNLIV 603
>NP_001124295
          Length = 1632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    YKRNIVLK 9
            +KR++VLK
Sbjct: 1290 FKRSMVLK 1297
>NP_001370
          Length = 1616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    YKRNIVLK 9
            +KR++VLK
Sbjct: 1274 FKRSMVLK 1281
>NP_001276081
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YKRNIVL 8
           Y RNI+L
Sbjct: 134 YPRNIIL 140
>NP_001170990
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YKRNIVL 8
           Y RNI+L
Sbjct: 231 YPRNIIL 237
>NP_001276082
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YKRNIVL 8
           Y RNI+L
Sbjct: 134 YPRNIIL 140
>NP_001276083
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  YKRNIVL 8
          Y RNI+L
Sbjct: 93 YPRNIIL 99
>NP_775966
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  KRNIVLK 9
          K+NI+LK
Sbjct: 7  KQNIILK 13
>NP_060191
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IYKRNIV 7
           +Y+RN+V
Sbjct: 936 LYRRNLV 942
>NP_055907
          Length = 3661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KRNIVLK 9
            +RN+VLK
Sbjct: 3285 RRNLVLK 3291
>XP_005260032
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IYKRNIV 7
           +Y+RN+V
Sbjct: 931 LYRRNLV 937
>XP_005260031
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IYKRNIV 7
           +Y+RN+V
Sbjct: 932 LYRRNLV 938
>XP_005260030
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IYKRNIV 7
           +Y+RN+V
Sbjct: 935 LYRRNLV 941
>XP_005260029
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IYKRNIV 7
           +Y+RN+V
Sbjct: 935 LYRRNLV 941
>XP_006722744
          Length = 1495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    YKRNIVLK 9
            +KR++VLK
Sbjct: 1153 FKRSMVLK 1160
>XP_005255242
          Length = 3609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KRNIVLK 9
            +RN+VLK
Sbjct: 3233 RRNLVLK 3239
>XP_005255241
          Length = 3637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KRNIVLK 9
            +RN+VLK
Sbjct: 3261 RRNLVLK 3267
>XP_005255240
          Length = 3663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KRNIVLK 9
            +RN+VLK
Sbjct: 3287 RRNLVLK 3293
>XP_005255239
          Length = 3689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KRNIVLK 9
            +RN+VLK
Sbjct: 3313 RRNLVLK 3319
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.152    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 428,281
Number of extensions: 856
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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