Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001005182                                                           17    2528
NP_001010986                                                           17    3301
NP_775965                                                              17    3301
NP_663696                                                              17    3301
XP_006724816                                                           17    3301
XP_006724815                                                           17    3301
XP_006724814                                                           17    3301
XP_005262462                                                           17    3301
NP_003030                                                              17    4312
NP_001005497                                                           17    4312
XP_006710899                                                           17    4312
XP_005263548                                                           17    4312
NP_001005326                                                           17    4312
NP_001245134                                                           16    5631
NP_001005489                                                           16    5631
NP_659505                                                              16    5631
NP_005250                                                              16    7355
NP_006209                                                              16    7355
NP_005004                                                              16    7355
NP_009046                                                              16    7355
NP_055056                                                              16    7355
XP_006718302                                                           16    7355
XP_005253005                                                           16    7355
XP_005253000                                                           16    7355
XP_005253004                                                           16    7355
XP_005253002                                                           16    7355
XP_005253001                                                           16    7355
XP_005252999                                                           16    7355
XP_005252998                                                           16    7355
XP_005252698                                                           16    7355
XP_006713721                                                           16    7355
NP_001005185                                                           16    7355
NP_703146                                                              16    7355
NP_703145                                                              16    7355
NP_001006942                                                           15    9605
NP_005778                                                              15    9605
XP_006723058                                                           15    9605
NP_001073903                                                           15    9605
>NP_001005182
          Length = 312

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  IYIFLLIT 8
          I++FLLIT
Sbjct: 25 IFVFLLIT 32
>NP_001010986
          Length = 1119

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IYIFLLITQ 9
           +Y+F+L+T+
Sbjct: 297 VYLFILLTK 305
>NP_775965
          Length = 1132

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IYIFLLITQ 9
           +Y+F+L+T+
Sbjct: 297 VYLFILLTK 305
>NP_663696
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   YIFLLITQ 9
           Y++LL+TQ
Sbjct: 543 YLYLLLTQ 550
>XP_006724816
          Length = 1105

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IYIFLLITQ 9
           +Y+F+L+T+
Sbjct: 294 VYLFILLTK 302
>XP_006724815
          Length = 1105

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IYIFLLITQ 9
           +Y+F+L+T+
Sbjct: 294 VYLFILLTK 302
>XP_006724814
          Length = 1116

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IYIFLLITQ 9
           +Y+F+L+T+
Sbjct: 294 VYLFILLTK 302
>XP_005262462
          Length = 1129

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IYIFLLITQ 9
           +Y+F+L+T+
Sbjct: 294 VYLFILLTK 302
>NP_003030
          Length = 501

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IYIFLLITQ 9
           IYIFL++ +
Sbjct: 454 IYIFLIVPE 462
>NP_001005497
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  IYIFLLIT 8
          ++IFLL+T
Sbjct: 25 LFIFLLVT 32
>XP_006710899
          Length = 491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IYIFLLITQ 9
           IYIFL++ +
Sbjct: 444 IYIFLIVPE 452
>XP_005263548
          Length = 501

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IYIFLLITQ 9
           IYIFL++ +
Sbjct: 454 IYIFLIVPE 462
>NP_001005326
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YIFLLIT 8
           YIF+L+T
Sbjct: 218 YIFILVT 224
>NP_001245134
          Length = 791

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IYIFLLIT 8
           +++FLLIT
Sbjct: 653 LFLFLLIT 660
>NP_001005489
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YIFLLIT 8
           Y+F+LIT
Sbjct: 216 YLFILIT 222
>NP_659505
          Length = 790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IYIFLLIT 8
           +++FLLIT
Sbjct: 653 LFLFLLIT 660
>NP_005250
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IYIFLLI 7
          IY+F+LI
Sbjct: 10 IYLFMLI 16
>NP_006209
          Length = 1068

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YIFLLITQ 9
          YIF+ +TQ
Sbjct: 68 YIFVSVTQ 75
>NP_005004
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  YIFLLIT 8
          Y FLLIT
Sbjct: 10 YCFLLIT 16
>NP_009046
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IYIFLLI 7
          IY+FLL+
Sbjct: 5  IYLFLLL 11
>NP_055056
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YIFLLIT 8
           Y FLLIT
Sbjct: 249 YYFLLIT 255
>XP_006718302
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  YIFLLIT 8
          Y FLLIT
Sbjct: 10 YCFLLIT 16
>XP_005253005
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  YIFLLIT 8
          Y FLLIT
Sbjct: 10 YCFLLIT 16
>XP_005253000
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  YIFLLIT 8
          Y FLLIT
Sbjct: 10 YCFLLIT 16
>XP_005253004
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  YIFLLIT 8
          Y FLLIT
Sbjct: 10 YCFLLIT 16
>XP_005253002
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  YIFLLIT 8
          Y FLLIT
Sbjct: 10 YCFLLIT 16
>XP_005253001
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  YIFLLIT 8
          Y FLLIT
Sbjct: 10 YCFLLIT 16
>XP_005252999
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  YIFLLIT 8
          Y FLLIT
Sbjct: 10 YCFLLIT 16
>XP_005252998
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  YIFLLIT 8
          Y FLLIT
Sbjct: 10 YCFLLIT 16
>XP_005252698
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YIFLLIT 8
           Y FLLIT
Sbjct: 213 YYFLLIT 219
>XP_006713721
          Length = 1068

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YIFLLITQ 9
          YIF+ +TQ
Sbjct: 68 YIFVSVTQ 75
>NP_001005185
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IYIFLLI 7
          IY+FLL+
Sbjct: 25 IYLFLLL 31
>NP_703146
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YIFLLIT 8
           YI++LIT
Sbjct: 218 YIYILIT 224
>NP_703145
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YIFLLIT 8
           YI++LIT
Sbjct: 214 YIYILIT 220
>NP_001006942
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IFLLITQ 9
           +FLL+TQ
Sbjct: 171 LFLLLTQ 177
>NP_005778
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IFLLITQ 9
           +FLL+TQ
Sbjct: 219 LFLLLTQ 225
>XP_006723058
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  YIFLLIT 8
          +IFLL+T
Sbjct: 52 FIFLLLT 58
>NP_001073903
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  YIFLLIT 8
          +IFLL+T
Sbjct: 81 FIFLLLT 87
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.354    0.170    0.474 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 378,742
Number of extensions: 891
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.9 bits)
S2: 28 (15.4 bits)

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