Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_003290                                                              20     509
NP_443199                                                              18    1935
NP_940905                                                              17    3301
XP_005248167                                                           17    3301
XP_006711360                                                           17    3301
XP_006711359                                                           17    3301
XP_006711357                                                           17    3301
NP_001121636                                                           17    4312
NP_000323                                                              17    4312
NP_065873                                                              16    5631
NP_001258932                                                           16    5631
XP_006717257                                                           16    5631
XP_006717256                                                           16    5631
NP_003633                                                              16    7355
XP_006712871                                                           16    7355
NP_001028252                                                           16    7355
NP_055441                                                              16    7355
NP_001073932                                                           15    9605
NP_001368                                                              15    9605
NP_002045                                                              15    9605
NP_787079                                                              15    9605
NP_061918                                                              15    9605
NP_001171894                                                           15    9605
NP_001137296                                                           15    9605
NP_659452                                                              15    9605
NP_001107604                                                           15    9605
NP_001091985                                                           15    9605
NP_060488                                                              15    9605
XP_005269054                                                           15    9605
XP_006718966                                                           15    9605
XP_005246845                                                           15    9605
XP_006712765                                                           15    9605
XP_006712764                                                           15    9605
XP_005246844                                                           15    9605
XP_006712763                                                           15    9605
XP_006712762                                                           15    9605
XP_006712761                                                           15    9605
XP_005245596                                                           15    9605
NP_055545                                                              15    9605
>NP_003290
          Length = 803

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IYFMAGSIR 9
           IYFMAGS R
Sbjct: 538 IYFMAGSSR 546
>NP_443199
          Length = 378

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYFMAGSIR 9
           IYF  GS+R
Sbjct: 313 IYFFVGSLR 321
>NP_940905
          Length = 1135

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           +Y+M GSI
Sbjct: 774 VYYMVGSI 781
>XP_005248167
          Length = 592

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YFMAGSIR 9
           YF+ GSIR
Sbjct: 371 YFVKGSIR 378
>XP_006711360
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           +Y+M GSI
Sbjct: 331 VYYMVGSI 338
>XP_006711359
          Length = 752

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           +Y+M GSI
Sbjct: 384 VYYMVGSI 391
>XP_006711357
          Length = 1142

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           +Y+M GSI
Sbjct: 774 VYYMVGSI 781
>NP_001121636
          Length = 815

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YFMAGSI 8
           YFM GSI
Sbjct: 573 YFMKGSI 579
>NP_000323
          Length = 815

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YFMAGSI 8
           YFM GSI
Sbjct: 573 YFMKGSI 579
>NP_065873
          Length = 1235

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           +Y+M GS+
Sbjct: 856 VYYMEGSV 863
>NP_001258932
          Length = 1211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           +Y+M GS+
Sbjct: 811 VYYMEGSV 818
>XP_006717257
          Length = 1083

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           +Y+M GS+
Sbjct: 683 VYYMEGSV 690
>XP_006717256
          Length = 1172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           +Y+M GS+
Sbjct: 772 VYYMEGSV 779
>NP_003633
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  IYFMAGSI 8
          +Y++AGS+
Sbjct: 76 LYYIAGSL 83
>XP_006712871
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  IYFMAGSI 8
          +Y++AGS+
Sbjct: 70 LYYIAGSL 77
>NP_001028252
          Length = 351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  FMAGSI 8
          FMAGSI
Sbjct: 49 FMAGSI 54
>NP_055441
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3 FMAGSI 8
         FMAGSI
Sbjct: 4 FMAGSI 9
>NP_001073932
          Length = 4314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    IYFMAGSI 8
            IY +AGS+
Sbjct: 2466 IYLLAGSM 2473
>NP_001368
          Length = 4307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    IYFMAGSI 8
            IY +AGS+
Sbjct: 2466 IYLLAGSM 2473
>NP_002045
          Length = 180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1 IYFMAG 6
         IYF+AG
Sbjct: 4 IYFVAG 9
>NP_787079
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   IYFMAG 6
           IYFM G
Sbjct: 199 IYFMTG 204
>NP_061918
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   YFMAGSI 8
           YF++GS+
Sbjct: 662 YFLSGSL 668
>NP_001171894
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   YFMAGSI 8
           YF++GS+
Sbjct: 662 YFLSGSL 668
>NP_001137296
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           I+FM GS+
Sbjct: 523 IFFMIGSM 530
>NP_659452
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IYFMAG 6
           +YF+AG
Sbjct: 290 VYFLAG 295
>NP_001107604
          Length = 2694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IYFMAGSI 8
            IYF  GSI
Sbjct: 1914 IYFYDGSI 1921
>NP_001091985
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IYFMAG 6
           +YF+AG
Sbjct: 290 VYFLAG 295
>NP_060488
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           I+FM GS+
Sbjct: 523 IFFMIGSM 530
>XP_005269054
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           I+FM GS+
Sbjct: 523 IFFMIGSM 530
>XP_006718966
          Length = 4300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    IYFMAGSI 8
            IY +AGS+
Sbjct: 2466 IYLLAGSM 2473
>XP_005246845
          Length = 1624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IYFMAGSI 8
           IYF  GSI
Sbjct: 831 IYFYDGSI 838
>XP_006712765
          Length = 2679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IYFMAGSI 8
            IYF  GSI
Sbjct: 1886 IYFYDGSI 1893
>XP_006712764
          Length = 2697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IYFMAGSI 8
            IYF  GSI
Sbjct: 1943 IYFYDGSI 1950
>XP_005246844
          Length = 2707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IYFMAGSI 8
            IYF  GSI
Sbjct: 1914 IYFYDGSI 1921
>XP_006712763
          Length = 2716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IYFMAGSI 8
            IYF  GSI
Sbjct: 1943 IYFYDGSI 1950
>XP_006712762
          Length = 2723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IYFMAGSI 8
            IYF  GSI
Sbjct: 1943 IYFYDGSI 1950
>XP_006712761
          Length = 2736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IYFMAGSI 8
            IYF  GSI
Sbjct: 1943 IYFYDGSI 1950
>XP_005245596
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YFMAGSIR 9
           YF+A S+R
Sbjct: 330 YFLAWSLR 337
>NP_055545
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IYFMAGSI 8
           +Y MAG++
Sbjct: 208 LYIMAGTV 215
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.153    0.453 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 423,299
Number of extensions: 529
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package