Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              21     229
XP_006718908                                                           21     229
XP_005271621                                                           21     229
XP_006718907                                                           21     229
XP_006718906                                                           21     229
XP_005271619                                                           21     229
XP_005271618                                                           21     229
NP_005091                                                              17    2528
NP_653080                                                              17    2528
XP_005267292                                                           17    2528
XP_005267291                                                           17    2528
XP_005267290                                                           17    2528
NP_525022                                                              17    3301
XP_005256994                                                           17    3301
XP_005256993                                                           17    3301
XP_005256992                                                           17    3301
XP_006721697                                                           17    3301
XP_006721696                                                           17    3301
XP_005256991                                                           17    3301
XP_005268276                                                           17    4312
NP_004265                                                              17    4312
NP_005742                                                              16    5631
NP_671714                                                              16    5631
NP_005115                                                              16    5631
NP_000480                                                              16    5631
NP_733468                                                              16    5631
NP_001265138                                                           16    5631
NP_653091                                                              16    5631
NP_001265139                                                           16    5631
NP_612114                                                              16    5631
NP_005834                                                              16    5631
NP_001139121                                                           16    5631
NP_066002                                                              16    5631
NP_001098998                                                           16    5631
NP_945346                                                              16    5631
NP_001139122                                                           16    5631
XP_006724730                                                           16    5631
XP_005262214                                                           16    5631
XP_005262213                                                           16    5631
XP_006724729                                                           16    5631
XP_005262212                                                           16    5631
XP_005262211                                                           16    5631
XP_005262210                                                           16    5631
XP_006723366                                                           16    5631
XP_006723365                                                           16    5631
XP_006715890                                                           16    5631
XP_005250160                                                           16    5631
XP_005250159                                                           16    5631
XP_006715354                                                           16    5631
XP_005249564                                                           16    5631
XP_006715353                                                           16    5631
NP_005466                                                              16    7355
NP_001273206                                                           16    7355
NP_001273207                                                           16    7355
NP_001273208                                                           16    7355
NP_006313                                                              16    7355
XP_005268350                                                           16    7355
XP_005253876                                                           16    7355
XP_005253875                                                           16    7355
NP_008835                                                              15    9605
NP_001075109                                                           15    9605
NP_067639                                                              15    9605
NP_001271236                                                           15    9605
XP_005257614                                                           15    9605
XP_005254649                                                           15    9605
XP_005254648                                                           15    9605
NP_819056                                                              15    9605
>NP_000042
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IYADEKSMD 9
            IYAD+KSMD
Sbjct: 1960 IYADKKSMD 1968
>XP_006718908
          Length = 1708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IYADEKSMD 9
           IYAD+KSMD
Sbjct: 612 IYADKKSMD 620
>XP_005271621
          Length = 2708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IYADEKSMD 9
            IYAD+KSMD
Sbjct: 1612 IYADKKSMD 1620
>XP_006718907
          Length = 3050

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IYADEKSMD 9
            IYAD+KSMD
Sbjct: 1954 IYADKKSMD 1962
>XP_006718906
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IYADEKSMD 9
            IYAD+KSMD
Sbjct: 1960 IYADKKSMD 1968
>XP_005271619
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IYADEKSMD 9
            IYAD+KSMD
Sbjct: 1960 IYADKKSMD 1968
>XP_005271618
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IYADEKSMD 9
            IYAD+KSMD
Sbjct: 1960 IYADKKSMD 1968
>NP_005091
          Length = 1782

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YADEKSMD 9
            YADEK+ D
Sbjct: 1270 YADEKTKD 1277
>NP_653080
          Length = 1684

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YADEKSMD 9
            YADEK+ D
Sbjct: 1172 YADEKTKD 1179
>XP_005267292
          Length = 1677

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YADEKSMD 9
            YADEK+ D
Sbjct: 1165 YADEKTKD 1172
>XP_005267291
          Length = 1684

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YADEKSMD 9
            YADEK+ D
Sbjct: 1172 YADEKTKD 1179
>XP_005267290
          Length = 1782

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    YADEKSMD 9
            YADEK+ D
Sbjct: 1270 YADEKTKD 1277
>NP_525022
          Length = 1624

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YADEKSMD 9
           + DEKSMD
Sbjct: 108 WPDEKSMD 115
>XP_005256994
          Length = 1443

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YADEKSMD 9
           + DEKSMD
Sbjct: 116 WPDEKSMD 123
>XP_005256993
          Length = 1543

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  YADEKSMD 9
          + DEKSMD
Sbjct: 27 WPDEKSMD 34
>XP_005256992
          Length = 1543

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  YADEKSMD 9
          + DEKSMD
Sbjct: 27 WPDEKSMD 34
>XP_006721697
          Length = 1625

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YADEKSMD 9
           + DEKSMD
Sbjct: 116 WPDEKSMD 123
>XP_006721696
          Length = 1632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YADEKSMD 9
           + DEKSMD
Sbjct: 116 WPDEKSMD 123
>XP_005256991
          Length = 1632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YADEKSMD 9
           + DEKSMD
Sbjct: 116 WPDEKSMD 123
>XP_005268276
          Length = 2320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YADEKS 7
           YADEKS
Sbjct: 736 YADEKS 741
>NP_004265
          Length = 2319

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YADEKS 7
           YADEKS
Sbjct: 736 YADEKS 741
>NP_005742
          Length = 3907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YADEKSM 8
            YADEK++
Sbjct: 1927 YADEKTL 1933
>NP_671714
          Length = 3899

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YADEKSM 8
            YADEK++
Sbjct: 1927 YADEKTL 1933
>NP_005115
          Length = 1475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IYADEKS 7
          +YADE+S
Sbjct: 87 VYADEES 93
>NP_000480
          Length = 2492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    YADEKSMD 9
            Y DE SMD
Sbjct: 1901 YFDEDSMD 1908
>NP_733468
          Length = 2342

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IYADEKSMD 9
           I++DE  MD
Sbjct: 170 IFSDENQMD 178

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IYADEKSMD 9
           IY+ E++MD
Sbjct: 503 IYSGEENMD 511
>NP_001265138
          Length = 1506

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IYADEKS 7
          +YADE+S
Sbjct: 87 VYADEES 93
>NP_653091
          Length = 2316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IYADEKSMD 9
           I++DE  MD
Sbjct: 144 IFSDENQMD 152

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IYADEKSMD 9
           IY+ E++MD
Sbjct: 477 IYSGEENMD 485
>NP_001265139
          Length = 1433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IYADEKS 7
          +YADE+S
Sbjct: 87 VYADEES 93
>NP_612114
          Length = 2454

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    YADEKSMD 9
            Y DE SMD
Sbjct: 1863 YFDEDSMD 1870
>NP_005834
          Length = 525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   IYADEKSMD 9
           +Y DE  MD
Sbjct: 290 VYIDEDKMD 298
>NP_001139121
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IYADEKSMD 9
           IY  EKS D
Sbjct: 555 IYTGEKSFD 563
>NP_066002
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IYADEKSMD 9
           IY  EKS D
Sbjct: 555 IYTGEKSFD 563
>NP_001098998
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IYADEKSMD 9
           IY DEK+++
Sbjct: 330 IYQDEKTIE 338
>NP_945346
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IYADEKSMD 9
           IY DEK+++
Sbjct: 330 IYQDEKTIE 338
>NP_001139122
          Length = 545

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IYADEKSMD 9
           IY  EKS D
Sbjct: 537 IYTGEKSFD 545
>XP_006724730
          Length = 2399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    YADEKSMD 9
            Y DE SMD
Sbjct: 1808 YFDEDSMD 1815
>XP_005262214
          Length = 2424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    YADEKSMD 9
            Y DE SMD
Sbjct: 1833 YFDEDSMD 1840
>XP_005262213
          Length = 2437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    YADEKSMD 9
            Y DE SMD
Sbjct: 1846 YFDEDSMD 1853
>XP_006724729
          Length = 2453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    YADEKSMD 9
            Y DE SMD
Sbjct: 1862 YFDEDSMD 1869
>XP_005262212
          Length = 2453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    YADEKSMD 9
            Y DE SMD
Sbjct: 1862 YFDEDSMD 1869
>XP_005262211
          Length = 2463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    YADEKSMD 9
            Y DE SMD
Sbjct: 1872 YFDEDSMD 1879
>XP_005262210
          Length = 2491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    YADEKSMD 9
            Y DE SMD
Sbjct: 1900 YFDEDSMD 1907
>XP_006723366
          Length = 458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IYADEKSMD 9
           IY  EKS D
Sbjct: 450 IYTGEKSFD 458
>XP_006723365
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IYADEKSMD 9
           IY  EKS D
Sbjct: 555 IYTGEKSFD 563
>XP_006715890
          Length = 3860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YADEKSM 8
            YADEK++
Sbjct: 1880 YADEKTL 1886
>XP_005250160
          Length = 3939

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YADEKSM 8
            YADEK++
Sbjct: 1959 YADEKTL 1965
>XP_005250159
          Length = 3952

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YADEKSM 8
            YADEK++
Sbjct: 1959 YADEKTL 1965
>XP_006715354
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IYADEKS 7
          +YADE+S
Sbjct: 87 VYADEES 93
>XP_005249564
          Length = 1457

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IYADEKS 7
          +YADE+S
Sbjct: 87 VYADEES 93
>XP_006715353
          Length = 1469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IYADEKS 7
          +YADE+S
Sbjct: 87 VYADEES 93
>NP_005466
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ADEKSMD 9
           ADE SMD
Sbjct: 206 ADEASMD 212
>NP_001273206
          Length = 897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YADEKSMD 9
           Y D++S+D
Sbjct: 297 YTDQRSLD 304
>NP_001273207
          Length = 824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YADEKSMD 9
           Y D++S+D
Sbjct: 307 YTDQRSLD 314
>NP_001273208
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YADEKSMD 9
           Y D++S+D
Sbjct: 307 YTDQRSLD 314
>NP_006313
          Length = 907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YADEKSMD 9
           Y D++S+D
Sbjct: 307 YTDQRSLD 314
>XP_005268350
          Length = 818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YADEKSMD 9
           Y D++S+D
Sbjct: 307 YTDQRSLD 314
>XP_005253876
          Length = 576

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ADEKSMD 9
           ADE SMD
Sbjct: 206 ADEASMD 212
>XP_005253875
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ADEKSMD 9
           ADE SMD
Sbjct: 206 ADEASMD 212
>NP_008835
          Length = 4128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YADEKSM 8
            +ADEKS+
Sbjct: 1115 HADEKSL 1121
>NP_001075109
          Length = 4097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    YADEKSM 8
            +ADEKS+
Sbjct: 1115 HADEKSL 1121
>NP_067639
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IYADEKSMD 9
           +Y+D KS++
Sbjct: 402 LYSDPKSLE 410
>NP_001271236
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  IYADEKSMD 9
          +Y+ +K MD
Sbjct: 13 VYSSKKEMD 21
>XP_005257614
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IYADEKSMD 9
           +Y+D KS++
Sbjct: 364 LYSDPKSLE 372
>XP_005254649
          Length = 1819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  IYADEKSMD 9
          +Y+ +K MD
Sbjct: 13 VYSSKKEMD 21
>XP_005254648
          Length = 1906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  IYADEKSMD 9
          +Y+ +K MD
Sbjct: 13 VYSSKKEMD 21
>NP_819056
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DEKSMD 9
           DEKS+D
Sbjct: 375 DEKSLD 380
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.126    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 551,971
Number of extensions: 990
Number of successful extensions: 69
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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