Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              18    1935
XP_005266703                                                           18    1935
NP_803879                                                              16    7355
NP_803881                                                              16    7355
NP_001258992                                                           16    7355
NP_110428                                                              16    7355
NP_001229291                                                           16    7355
NP_001258991                                                           16    7355
NP_001092270                                                           16    7355
NP_001258990                                                           16    7355
XP_006724671                                                           16    7355
XP_006724670                                                           16    7355
NP_597732                                                              15    9605
XP_006722741                                                           15    9605
XP_006722740                                                           15    9605
XP_006722739                                                           15    9605
XP_006722738                                                           15    9605
XP_006722737                                                           15    9605
XP_005259567                                                           15    9605
XP_005267570                                                           15    9605
XP_006720171                                                           15    9605
XP_005267569                                                           15    9605
XP_005267568                                                           15    9605
XP_006720170                                                           15    9605
XP_006720169                                                           15    9605
>NP_443179
          Length = 2170

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IYAAEAQLL 9
            IYAAEAQ L
Sbjct: 1994 IYAAEAQPL 2002
>XP_005266703
          Length = 1501

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IYAAEAQLL 9
            IYAAEAQ L
Sbjct: 1325 IYAAEAQPL 1333
>NP_803879
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YAAEAQ 7
           YAAEAQ
Sbjct: 152 YAAEAQ 157
>NP_803881
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YAAEAQ 7
           YAAEAQ
Sbjct: 152 YAAEAQ 157
>NP_001258992
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YAAEAQ 7
           YAAEAQ
Sbjct: 152 YAAEAQ 157
>NP_110428
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YAAEAQ 7
           YAAEAQ
Sbjct: 152 YAAEAQ 157
>NP_001229291
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YAAEAQ 7
           YAAEAQ
Sbjct: 152 YAAEAQ 157
>NP_001258991
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YAAEAQ 7
           YAAEAQ
Sbjct: 152 YAAEAQ 157
>NP_001092270
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YAAEAQ 7
           YAAEAQ
Sbjct: 152 YAAEAQ 157
>NP_001258990
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YAAEAQ 7
           YAAEAQ
Sbjct: 152 YAAEAQ 157
>XP_006724671
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YAAEAQ 7
           YAAEAQ
Sbjct: 152 YAAEAQ 157
>XP_006724670
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YAAEAQ 7
           YAAEAQ
Sbjct: 152 YAAEAQ 157
>NP_597732
          Length = 1146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    YAAEAQL 8
            +AAEAQL
Sbjct: 1014 HAAEAQL 1020
>XP_006722741
          Length = 1117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   YAAEAQL 8
           +AAEAQL
Sbjct: 985 HAAEAQL 991
>XP_006722740
          Length = 1153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    YAAEAQL 8
            +AAEAQL
Sbjct: 1021 HAAEAQL 1027
>XP_006722739
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    YAAEAQL 8
            +AAEAQL
Sbjct: 1049 HAAEAQL 1055
>XP_006722738
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    YAAEAQL 8
            +AAEAQL
Sbjct: 1049 HAAEAQL 1055
>XP_006722737
          Length = 1182

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    YAAEAQL 8
            +AAEAQL
Sbjct: 1050 HAAEAQL 1056
>XP_005259567
          Length = 1217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    YAAEAQL 8
            +AAEAQL
Sbjct: 1085 HAAEAQL 1091
>XP_005267570
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYAAEAQLL 9
           IYA  +QLL
Sbjct: 145 IYALNSQLL 153
>XP_006720171
          Length = 1240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYAAEAQLL 9
           IYA  +QLL
Sbjct: 166 IYALNSQLL 174
>XP_005267569
          Length = 1340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYAAEAQLL 9
           IYA  +QLL
Sbjct: 145 IYALNSQLL 153
>XP_005267568
          Length = 1340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYAAEAQLL 9
           IYA  +QLL
Sbjct: 145 IYALNSQLL 153
>XP_006720170
          Length = 1354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYAAEAQLL 9
           IYA  +QLL
Sbjct: 159 IYALNSQLL 167
>XP_006720169
          Length = 1361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IYAAEAQLL 9
           IYA  +QLL
Sbjct: 166 IYALNSQLL 174
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.132    0.325 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 279,031
Number of extensions: 230
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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