Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_037440                                                              19     869
XP_005247460                                                           19     869
XP_005247459                                                           19     869
NP_036423                                                              17    2528
NP_036471                                                              17    2528
XP_006719768                                                           17    2528
NP_001122306                                                           17    4312
NP_000524                                                              17    4312
NP_955772                                                              17    4312
NP_064505                                                              17    4312
NP_056996                                                              17    4312
XP_005250985                                                           17    4312
XP_006716634                                                           17    4312
XP_006712699                                                           17    4312
XP_006712698                                                           17    4312
XP_006712697                                                           17    4312
NP_055032                                                              16    5631
NP_001017425                                                           16    5631
NP_000557                                                              16    5631
NP_001017424                                                           16    5631
NP_001004340                                                           16    5631
NP_001017986                                                           16    5631
XP_005245015                                                           16    5631
XP_005245014                                                           16    5631
NP_001077430                                                           16    7355
NP_775907                                                              16    7355
NP_001257906                                                           16    7355
NP_001257904                                                           16    7355
NP_001257905                                                           16    7355
NP_055576                                                              16    7355
NP_000858                                                              16    7355
NP_003244                                                              16    7355
NP_775099                                                              16    7355
NP_056472                                                              16    7355
NP_940894                                                              16    7355
NP_787057                                                              16    7355
NP_775760                                                              16    7355
NP_001231785                                                           16    7355
NP_001180380                                                           16    7355
XP_005261097                                                           16    7355
XP_005261096                                                           16    7355
XP_005261095                                                           16    7355
XP_005261094                                                           16    7355
XP_005258866                                                           16    7355
XP_005253559                                                           16    7355
XP_005253558                                                           16    7355
XP_005253557                                                           16    7355
XP_005253556                                                           16    7355
XP_005253555                                                           16    7355
XP_006714502                                                           16    7355
XP_005264808                                                           16    7355
XP_005264807                                                           16    7355
XP_005264806                                                           16    7355
XP_005264805                                                           16    7355
XP_005264804                                                           16    7355
XP_005246577                                                           16    7355
XP_006712545                                                           16    7355
NP_000857                                                              16    7355
NP_919227                                                              16    7355
NP_003741                                                              15    9605
NP_001002020                                                           15    9605
NP_060717                                                              15    9605
NP_003560                                                              15    9605
NP_001002019                                                           15    9605
NP_001137430                                                           15    9605
XP_005269724                                                           15    9605
NP_079491                                                              15    9605
NP_001135780                                                           15    9605
>NP_037440
          Length = 319

 Score = 18.9 bits (37), Expect =   869
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IVSTVIWLL 9
           ++STV+WL+
Sbjct: 133 MISTVVWLM 141
>XP_005247460
          Length = 319

 Score = 18.9 bits (37), Expect =   869
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IVSTVIWLL 9
           ++STV+WL+
Sbjct: 133 MISTVVWLM 141
>XP_005247459
          Length = 319

 Score = 18.9 bits (37), Expect =   869
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IVSTVIWLL 9
           ++STV+WL+
Sbjct: 133 MISTVVWLM 141
>NP_036423
          Length = 2120

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVIWLL 9
           STV+W+L
Sbjct: 432 STVVWML 438
>NP_036471
          Length = 294

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  IVSTVIWLL 9
          I STV WL+
Sbjct: 26 IYSTVFWLI 34
>XP_006719768
          Length = 2120

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVIWLL 9
           STV+W+L
Sbjct: 432 STVVWML 438
>NP_001122306
          Length = 277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TVIWLL 9
           TV+WLL
Sbjct: 160 TVVWLL 165
>NP_000524
          Length = 277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TVIWLL 9
           TV+WLL
Sbjct: 160 TVVWLL 165
>NP_955772
          Length = 242

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TVIWLL 9
           TV+WLL
Sbjct: 125 TVVWLL 130
>NP_064505
          Length = 1555

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IVSTVIWL 8
          +V TV+WL
Sbjct: 29 VVLTVLWL 36
>NP_056996
          Length = 1406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    IVSTVIWLL 9
            +VST +WL+
Sbjct: 1260 LVSTGLWLM 1268
>XP_005250985
          Length = 1406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    IVSTVIWLL 9
            +VST +WL+
Sbjct: 1260 LVSTGLWLM 1268
>XP_006716634
          Length = 1420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    IVSTVIWLL 9
            +VST +WL+
Sbjct: 1274 LVSTGLWLM 1282
>XP_006712699
          Length = 1544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IVSTVIWL 8
          +V TV+WL
Sbjct: 18 VVLTVLWL 25
>XP_006712698
          Length = 1547

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IVSTVIWL 8
          +V TV+WL
Sbjct: 29 VVLTVLWL 36
>XP_006712697
          Length = 1549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IVSTVIWL 8
          +V TV+WL
Sbjct: 23 VVLTVLWL 30
>NP_055032
          Length = 411

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IVSTVIWLL 9
           I+ST+I++L
Sbjct: 208 IISTIIFIL 216
>NP_001017425
          Length = 426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IVSTVIWLL 9
           I+ST+I++L
Sbjct: 223 IISTIIFIL 231
>NP_000557
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   IVSTVIWL 8
           +V+TV+W+
Sbjct: 304 LVNTVLWV 311
>NP_001017424
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IVSTVIWLL 9
           I+ST+I++L
Sbjct: 219 IISTIIFIL 227
>NP_001004340
          Length = 188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   IVSTVIWL 8
           +V+TV+W+
Sbjct: 118 LVNTVLWV 125
>NP_001017986
          Length = 280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   IVSTVIWL 8
           +V+TV+W+
Sbjct: 210 LVNTVLWV 217
>XP_005245015
          Length = 282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   IVSTVIWL 8
           +V+TV+W+
Sbjct: 212 LVNTVLWV 219
>XP_005245014
          Length = 375

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   IVSTVIWL 8
           +V+TV+W+
Sbjct: 305 LVNTVLWV 312
>NP_001077430
          Length = 1523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    IVSTVIWL 8
            +VST +W+
Sbjct: 1455 LVSTFLWI 1462
>NP_775907
          Length = 1518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    IVSTVIWL 8
            +VST +W+
Sbjct: 1450 LVSTFLWI 1457
>NP_001257906
          Length = 335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VSTVIW 7
           VST+IW
Sbjct: 100 VSTLIW 105
>NP_001257904
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VSTVIW 7
           VST+IW
Sbjct: 100 VSTLIW 105
>NP_001257905
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VSTVIW 7
           VST+IW
Sbjct: 113 VSTLIW 118
>NP_055576
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VSTVIW 7
           VST+IW
Sbjct: 100 VSTLIW 105
>NP_000858
          Length = 481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TVIWLL 9
           TV+WL+
Sbjct: 177 TVVWLI 182
>NP_003244
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    STVIWL 8
            +TVIWL
Sbjct: 1271 TTVIWL 1276
>NP_775099
          Length = 2595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IVSTVIWL 8
           I+S V WL
Sbjct: 595 IISQVFWL 602
>NP_056472
          Length = 2277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IVSTVIWL 8
           I+S V WL
Sbjct: 277 IISQVFWL 284
>NP_940894
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  IVSTVIW 7
          +V+TV+W
Sbjct: 39 LVTTVLW 45
>NP_787057
          Length = 774

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           IVSTV+ LL
Sbjct: 336 IVSTVLLLL 344
>NP_775760
          Length = 1585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   VSTVIW 7
           +STV+W
Sbjct: 565 ISTVLW 570
>NP_001231785
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  IVSTVIW 7
          +V+TV+W
Sbjct: 27 LVTTVLW 33
>NP_001180380
          Length = 882

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           IVSTV+ LL
Sbjct: 444 IVSTVLLLL 452
>XP_005261097
          Length = 1452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    STVIWL 8
            +TVIWL
Sbjct: 1271 TTVIWL 1276
>XP_005261096
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    STVIWL 8
            +TVIWL
Sbjct: 1271 TTVIWL 1276
>XP_005261095
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    STVIWL 8
            +TVIWL
Sbjct: 1271 TTVIWL 1276
>XP_005261094
          Length = 1591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    STVIWL 8
            +TVIWL
Sbjct: 1271 TTVIWL 1276
>XP_005258866
          Length = 1486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    IVSTVIWL 8
            +VST +W+
Sbjct: 1418 LVSTFLWI 1425
>XP_005253559
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           IVSTV+ LL
Sbjct: 202 IVSTVLLLL 210
>XP_005253558
          Length = 897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           IVSTV+ LL
Sbjct: 459 IVSTVLLLL 467
>XP_005253557
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           IVSTV+ LL
Sbjct: 466 IVSTVLLLL 474
>XP_005253556
          Length = 944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           IVSTV+ LL
Sbjct: 506 IVSTVLLLL 514
>XP_005253555
          Length = 966

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           IVSTV+ LL
Sbjct: 528 IVSTVLLLL 536
>XP_006714502
          Length = 1064

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  VSTVIW 7
          +STV+W
Sbjct: 48 ISTVLW 53
>XP_005264808
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           I+ T++W++
Sbjct: 142 IMITIVWII 150
>XP_005264807
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           I+ T++W++
Sbjct: 142 IMITIVWII 150
>XP_005264806
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           I+ T++W++
Sbjct: 142 IMITIVWII 150
>XP_005264805
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           I+ T++W++
Sbjct: 142 IMITIVWII 150
>XP_005264804
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           I+ T++W++
Sbjct: 142 IMITIVWII 150
>XP_005246577
          Length = 362

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  TVIWLL 9
          TV+WL+
Sbjct: 58 TVVWLI 63
>XP_006712545
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TVIWLL 9
           TV+WL+
Sbjct: 152 TVVWLI 157
>NP_000857
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IVSTVIWLL 9
           I+ T++W++
Sbjct: 142 IMITIVWII 150
>NP_919227
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IVSTVIWL 8
           I+S ++WL
Sbjct: 257 IISALLWL 264
>NP_003741
          Length = 1382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   VSTVIW 7
           VSTV W
Sbjct: 279 VSTVFW 284
>NP_001002020
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IVSTVIWLL 9
           +VS  +WL+
Sbjct: 127 VVSLKVWLI 135
>NP_060717
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IVSTVIWL 8
           I+ST+ W+
Sbjct: 311 ILSTISWM 318
>NP_003560
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   IVSTVIW 7
           I+S +IW
Sbjct: 251 IISLIIW 257
>NP_001002019
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IVSTVIWLL 9
           +VS  +WL+
Sbjct: 127 VVSLKVWLI 135
>NP_001137430
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IVSTVIWL 8
           I+ST+ W+
Sbjct: 275 ILSTISWM 282
>XP_005269724
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  IVSTVIWLL 9
          I STV W +
Sbjct: 26 IYSTVFWTI 34
>NP_079491
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IVSTVIWLL 9
           +VS  +WL+
Sbjct: 155 VVSLKVWLI 163
>NP_001135780
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   STVIW 7
           STVIW
Sbjct: 760 STVIW 764
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.144    0.493 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 572,793
Number of extensions: 498
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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