Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              19     665
XP_006717990                                                           19     665
XP_006717989                                                           19     665
NP_689777                                                              17    3301
NP_060360                                                              17    3301
XP_006716573                                                           17    3301
XP_005250858                                                           17    3301
XP_005250857                                                           17    3301
XP_005260633                                                           17    4312
NP_006837                                                              16    5631
NP_001121170                                                           16    5631
NP_001121171                                                           16    5631
NP_004123                                                              16    7355
NP_005434                                                              16    7355
NP_001171131                                                           16    7355
NP_071328                                                              16    7355
NP_004661                                                              16    7355
NP_001002909                                                           16    7355
NP_001015880                                                           16    7355
XP_006721846                                                           16    7355
XP_006721845                                                           16    7355
XP_006721844                                                           16    7355
XP_006716779                                                           16    7355
XP_005272199                                                           16    7355
NP_055644                                                              16    7355
NP_997235                                                              15    9605
NP_001017420                                                           15    9605
NP_001264243                                                           15    9605
NP_073568                                                              15    9605
NP_653292                                                              15    9605
NP_001264242                                                           15    9605
NP_001074003                                                           15    9605
XP_005254452                                                           15    9605
XP_005254451                                                           15    9605
XP_006716360                                                           15    9605
XP_006714247                                                           15    9605
XP_005262992                                                           15    9605
XP_005245510                                                           15    9605
>NP_000305
          Length = 403

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  IVSRNKRR 8
          IVSRNKRR
Sbjct: 8  IVSRNKRR 15
>XP_006717990
          Length = 175

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  IVSRNKRR 8
          IVSRNKRR
Sbjct: 8  IVSRNKRR 15
>XP_006717989
          Length = 388

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  IVSRNKRR 8
          IVSRNKRR
Sbjct: 8  IVSRNKRR 15
>NP_689777
          Length = 3997

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IVSRNKRRS 9
            + SRN+RRS
Sbjct: 1440 LTSRNERRS 1448
>NP_060360
          Length = 4022

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IVSRNKRRS 9
            + SRN+RRS
Sbjct: 1465 LTSRNERRS 1473
>XP_006716573
          Length = 1776

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IVSRNKRRS 9
            + SRN+RRS
Sbjct: 1465 LTSRNERRS 1473
>XP_005250858
          Length = 4022

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IVSRNKRRS 9
            + SRN+RRS
Sbjct: 1465 LTSRNERRS 1473
>XP_005250857
          Length = 4022

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IVSRNKRRS 9
            + SRN+RRS
Sbjct: 1465 LTSRNERRS 1473
>XP_005260633
          Length = 1364

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 IVSRNKRR 8
         + SRNKRR
Sbjct: 1 MASRNKRR 8
>NP_006837
          Length = 1064

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           SRNKR+S
Sbjct: 421 SRNKRQS 427
>NP_001121170
          Length = 1094

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           SRNKR+S
Sbjct: 421 SRNKRQS 427
>NP_001121171
          Length = 916

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           SRNKR+S
Sbjct: 421 SRNKRQS 427
>NP_004123
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           SR+KRRS
Sbjct: 166 SRHKRRS 172
>NP_005434
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  VSRNKR 7
          VSRNKR
Sbjct: 35 VSRNKR 40
>NP_001171131
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           SR+KRRS
Sbjct: 140 SRHKRRS 146
>NP_071328
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VSRNKRRS 9
           VSR KRRS
Sbjct: 731 VSRLKRRS 738
>NP_004661
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  VSRNKR 7
          VSRNKR
Sbjct: 25 VSRNKR 30
>NP_001002909
          Length = 1502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           SR+KRRS
Sbjct: 968 SRSKRRS 974
>NP_001015880
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  VSRNKR 7
          VSRNKR
Sbjct: 25 VSRNKR 30
>XP_006721846
          Length = 1424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           SR+KRRS
Sbjct: 890 SRSKRRS 896
>XP_006721845
          Length = 1424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           SR+KRRS
Sbjct: 890 SRSKRRS 896
>XP_006721844
          Length = 1424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           SR+KRRS
Sbjct: 890 SRSKRRS 896
>XP_006716779
          Length = 2399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IVSRNKRR 8
           I++RNKR+
Sbjct: 408 ILTRNKRK 415
>XP_005272199
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SRNKRRS 9
          SR+KRRS
Sbjct: 54 SRDKRRS 60
>NP_055644
          Length = 1031

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SRNKRRS 9
          SR+KRRS
Sbjct: 54 SRDKRRS 60
>NP_997235
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           S+NKRR+
Sbjct: 292 SKNKRRA 298
>NP_001017420
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VSRNKRRS 9
           VSRN R S
Sbjct: 158 VSRNSRNS 165
>NP_001264243
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           +RNKRR+
Sbjct: 454 TRNKRRA 460
>NP_073568
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SRNKRRS 9
          ++NKRRS
Sbjct: 44 AKNKRRS 50
>NP_653292
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IVSRNKRR 8
           ++ RN+RR
Sbjct: 430 LIQRNRRR 437
>NP_001264242
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           +RNKRR+
Sbjct: 454 TRNKRRA 460
>NP_001074003
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VSRNKRRS 9
            V +NKRR+
Sbjct: 1249 VGKNKRRT 1256
>XP_005254452
          Length = 2188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VSRNKRRS 9
            V +NKRR+
Sbjct: 1249 VGKNKRRT 1256
>XP_005254451
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VSRNKRRS 9
            V +NKRR+
Sbjct: 1249 VGKNKRRT 1256
>XP_006716360
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VSRNKRRS 9
           VSRN R S
Sbjct: 158 VSRNSRNS 165
>XP_006714247
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           S+NKRR+
Sbjct: 160 SKNKRRA 166
>XP_005262992
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SRNKRRS 9
           S+NKRR+
Sbjct: 292 SKNKRRA 298
>XP_005245510
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SRNKRRS 9
          ++NKRRS
Sbjct: 44 AKNKRRS 50
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.127    0.308 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 453,888
Number of extensions: 530
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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