Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     665
NP_671714                                                              19     665
XP_006715890                                                           19     665
XP_005250160                                                           19     665
XP_005250159                                                           19     665
NP_055786                                                              18    1935
NP_055952                                                              18    1935
XP_005250906                                                           18    1935
NP_001138766                                                           16    7355
NP_060767                                                              16    7355
NP_001138765                                                           16    7355
XP_005265373                                                           16    7355
NP_783863                                                              15    9605
NP_001001998                                                           15    9605
NP_944489                                                              15    9605
NP_001074003                                                           15    9605
XP_005254452                                                           15    9605
XP_005254451                                                           15    9605
XP_006719749                                                           15    9605
XP_005269275                                                           15    9605
XP_005263533                                                           15    9605
XP_005263532                                                           15    9605
NP_115512                                                              15    9605
NP_002676                                                              15    9605
>NP_005742
          Length = 3907

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IVRQSINDE 9
            IVRQSI+DE
Sbjct: 1560 IVRQSIHDE 1568
>NP_671714
          Length = 3899

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IVRQSINDE 9
            IVRQSI+DE
Sbjct: 1560 IVRQSIHDE 1568
>XP_006715890
          Length = 3860

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IVRQSINDE 9
            IVRQSI+DE
Sbjct: 1560 IVRQSIHDE 1568
>XP_005250160
          Length = 3939

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IVRQSINDE 9
            IVRQSI+DE
Sbjct: 1560 IVRQSIHDE 1568
>XP_005250159
          Length = 3952

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IVRQSINDE 9
            IVRQSI+DE
Sbjct: 1560 IVRQSIHDE 1568
>NP_055786
          Length = 817

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IVRQSINDE 9
           +VR+++NDE
Sbjct: 174 VVRKTVNDE 182
>NP_055952
          Length = 821

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IVRQSINDE 9
           +VR+++NDE
Sbjct: 175 VVRKTVNDE 183
>XP_005250906
          Length = 785

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IVRQSINDE 9
           +VR+++NDE
Sbjct: 139 VVRKTVNDE 147
>NP_001138766
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVRQSIND 8
           + RQS+ND
Sbjct: 590 LFRQSLND 597
>NP_060767
          Length = 654

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVRQSIND 8
           + RQS+ND
Sbjct: 632 LFRQSLND 639
>NP_001138765
          Length = 636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVRQSIND 8
           + RQS+ND
Sbjct: 614 LFRQSLND 621
>XP_005265373
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVRQSIND 8
           + RQS+ND
Sbjct: 577 LFRQSLND 584
>NP_783863
          Length = 1027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRQSINDE 9
           VR+ +NDE
Sbjct: 125 VREFLNDE 132
>NP_001001998
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVRQSIND 8
           +VRQ IN+
Sbjct: 561 LVRQQINE 568
>NP_944489
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRQSINDE 9
           VR+ +NDE
Sbjct: 125 VREFLNDE 132
>NP_001074003
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    IVRQSINDE 9
            ++R S+N+E
Sbjct: 1066 VIRTSLNNE 1074
>XP_005254452
          Length = 2188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    IVRQSINDE 9
            ++R S+N+E
Sbjct: 1066 VIRTSLNNE 1074
>XP_005254451
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    IVRQSINDE 9
            ++R S+N+E
Sbjct: 1066 VIRTSLNNE 1074
>XP_006719749
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRQSINDE 9
           VR+ +NDE
Sbjct: 125 VREFLNDE 132
>XP_005269275
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRQSINDE 9
           VR+ +NDE
Sbjct: 125 VREFLNDE 132
>XP_005263533
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVRQSIND 8
           +VRQ IN+
Sbjct: 129 LVRQQINE 136
>XP_005263532
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVRQSIND 8
           +VRQ IN+
Sbjct: 585 LVRQQINE 592
>NP_115512
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IVRQSINDE 9
           +VR  +ND+
Sbjct: 498 VVRHGVNDK 506
>NP_002676
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVRQSIND 8
           +VRQ IN+
Sbjct: 561 LVRQQINE 568
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.132    0.323 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 422,050
Number of extensions: 736
Number of successful extensions: 24
Number of sequences better than 10000.0: 24
Number of HSP's gapped: 24
Number of HSP's successfully gapped: 24
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package