Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1135
XP_005262424                                                           18    1135
NP_060729                                                              17    4312
XP_005253074                                                           17    4312
XP_006718326                                                           17    4312
XP_005253073                                                           17    4312
XP_003960128                                                           16    5631
NP_954980                                                              16    5631
NP_001093591                                                           16    7355
NP_001093590                                                           16    7355
XP_003960172                                                           16    7355
XP_003119008                                                           16    7355
XP_003119853                                                           16    7355
NP_001032401                                                           16    7355
NP_055508                                                              16    7355
NP_000283                                                              15    9605
NP_061135                                                              15    9605
XP_006724561                                                           15    9605
XP_005274607                                                           15    9605
XP_005274605                                                           15    9605
XP_006724560                                                           15    9605
XP_006724559                                                           15    9605
XP_006715571                                                           15    9605
XP_005246783                                                           15    9605
NP_065994                                                              15    9605
NP_002535                                                              15    9605
>NP_722576
          Length = 3080

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IVNLANITI 9
            IV+LANITI
Sbjct: 2455 IVDLANITI 2463
>XP_005262424
          Length = 2875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IVNLANITI 9
            IV+LANITI
Sbjct: 2250 IVDLANITI 2258
>NP_060729
          Length = 1141

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IVNLANITI 9
           +VNLAN+ I
Sbjct: 658 LVNLANLLI 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IVNLANI 7
           +VNLAN+
Sbjct: 265 LVNLANV 271
>XP_005253074
          Length = 956

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IVNLANITI 9
           +VNLAN+ I
Sbjct: 658 LVNLANLLI 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IVNLANI 7
           +VNLAN+
Sbjct: 265 LVNLANV 271
>XP_006718326
          Length = 968

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IVNLANITI 9
           +VNLAN+ I
Sbjct: 428 LVNLANLLI 436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IVNLANI 7
          +VNLAN+
Sbjct: 35 LVNLANV 41
>XP_005253073
          Length = 1198

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IVNLANITI 9
           +VNLAN+ I
Sbjct: 658 LVNLANLLI 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IVNLANI 7
           +VNLAN+
Sbjct: 265 LVNLANV 271
>XP_003960128
          Length = 160

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  IVNLANITI 9
          I NL+N+TI
Sbjct: 39 IKNLSNLTI 47
>NP_954980
          Length = 159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  IVNLANITI 9
          I NL+N+TI
Sbjct: 38 IKNLSNLTI 46
>NP_001093591
          Length = 765

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VNLANITI 9
           + LANIT+
Sbjct: 307 IQLANITV 314
>NP_001093590
          Length = 811

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VNLANITI 9
           + LANIT+
Sbjct: 353 IQLANITV 360
>XP_003960172
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NLANIT 8
           NLANIT
Sbjct: 389 NLANIT 394
>XP_003119008
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NLANIT 8
           NLANIT
Sbjct: 389 NLANIT 394
>XP_003119853
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NLANIT 8
           NLANIT
Sbjct: 389 NLANIT 394
>NP_001032401
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VNLANITI 9
           + LANIT+
Sbjct: 278 IQLANITV 285
>NP_055508
          Length = 883

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VNLANITI 9
           + LANIT+
Sbjct: 425 IQLANITV 432
>NP_000283
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VNLANIT 8
           VNL N+T
Sbjct: 273 VNLVNVT 279
>NP_061135
          Length = 648

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VNLANIT 8
           VNL NIT
Sbjct: 385 VNLKNIT 391
>XP_006724561
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  VNLANIT 8
          VNL N+T
Sbjct: 91 VNLVNVT 97
>XP_005274607
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VNLANIT 8
           VNL N+T
Sbjct: 273 VNLVNVT 279
>XP_005274605
          Length = 1217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VNLANIT 8
           VNL N+T
Sbjct: 273 VNLVNVT 279
>XP_006724560
          Length = 1225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VNLANIT 8
           VNL N+T
Sbjct: 273 VNLVNVT 279
>XP_006724559
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VNLANIT 8
           VNL N+T
Sbjct: 273 VNLVNVT 279
>XP_006715571
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VNLANIT 8
           VNL NIT
Sbjct: 365 VNLKNIT 371
>XP_005246783
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VNLANITI 9
           VN++NI+I
Sbjct: 173 VNISNISI 180
>NP_065994
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VNLANITI 9
           VN++NI+I
Sbjct: 173 VNISNISI 180
>NP_002535
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IVNLANIT 8
           ++NL N+T
Sbjct: 187 LINLTNLT 194
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.144    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 306,193
Number of extensions: 464
Number of successful extensions: 30
Number of sequences better than 10000.0: 26
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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