Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              19     869
NP_115996                                                              17    3301
NP_001258925                                                           17    3301
NP_001258924                                                           17    3301
NP_001130000                                                           16    5631
NP_006207                                                              16    5631
NP_001130002                                                           16    5631
NP_055553                                                              16    5631
XP_005257924                                                           16    5631
XP_005257923                                                           16    5631
XP_005257922                                                           16    5631
XP_005257921                                                           16    5631
XP_006722263                                                           16    5631
XP_005257920                                                           16    5631
XP_005246699                                                           16    5631
XP_005246698                                                           16    5631
NP_002728                                                              15    9605
NP_001165375                                                           15    9605
NP_055518                                                              15    9605
NP_006435                                                              15    9605
NP_001036016                                                           15    9605
NP_001252531                                                           15    9605
NP_001036015                                                           15    9605
XP_006716996                                                           15    9605
XP_005276812                                                           15    9605
XP_006713491                                                           15    9605
XP_005276811                                                           15    9605
XP_006713490                                                           15    9605
XP_005276810                                                           15    9605
XP_005276809                                                           15    9605
XP_006713489                                                           15    9605
XP_005276808                                                           15    9605

>NP_002430
          Length = 1137

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           IVDGI TRM
Sbjct: 931 IVDGIFTRM 939



>NP_115996
          Length = 461

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VDGISTRM 9
           +DG+ TRM
Sbjct: 268 IDGLETRM 275



>NP_001258925
          Length = 459

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VDGISTRM 9
           +DG+ TRM
Sbjct: 266 IDGLETRM 273



>NP_001258924
          Length = 460

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VDGISTRM 9
           +DG+ TRM
Sbjct: 267 IDGLETRM 274



>NP_001130000
          Length = 397

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           ++DG+ TR+
Sbjct: 173 LIDGVLTRL 181



>NP_006207
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           ++DG+ TR+
Sbjct: 173 LIDGVLTRL 181



>NP_001130002
          Length = 409

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           ++DG+ TR+
Sbjct: 185 LIDGVLTRL 193



>NP_055553
          Length = 1356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVDGISTR 8
           + DG+STR
Sbjct: 449 LTDGLSTR 456



>XP_005257924
          Length = 1122

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVDGISTR 8
           + DG+STR
Sbjct: 181 LTDGLSTR 188



>XP_005257923
          Length = 1131

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVDGISTR 8
           + DG+STR
Sbjct: 190 LTDGLSTR 197



>XP_005257922
          Length = 1366

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVDGISTR 8
           + DG+STR
Sbjct: 459 LTDGLSTR 466



>XP_005257921
          Length = 1370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVDGISTR 8
           + DG+STR
Sbjct: 459 LTDGLSTR 466



>XP_006722263
          Length = 1390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVDGISTR 8
           + DG+STR
Sbjct: 449 LTDGLSTR 456



>XP_005257920
          Length = 1390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IVDGISTR 8
           + DG+STR
Sbjct: 449 LTDGLSTR 456



>XP_005246699
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           ++DG+ TR+
Sbjct: 173 LIDGVLTRL 181



>XP_005246698
          Length = 410

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           ++DG+ TR+
Sbjct: 185 LIDGVLTRL 193



>NP_002728
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   IVDGISTR 8
           ++DG++TR
Sbjct: 489 MMDGVTTR 496



>NP_001165375
          Length = 1506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           I +GI+TR+
Sbjct: 904 IANGIATRL 912



>NP_055518
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           I +GI+TR+
Sbjct: 905 IANGIATRL 913



>NP_006435
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VDGIST 7
            VDG+ST
Sbjct: 1162 VDGVST 1167



>NP_001036016
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VDGIST 7
            VDG+ST
Sbjct: 1162 VDGVST 1167



>NP_001252531
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VDGIST 7
            VDG+ST
Sbjct: 1162 VDGVST 1167



>NP_001036015
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VDGIST 7
            VDG+ST
Sbjct: 1162 VDGVST 1167



>XP_006716996
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    VDGIST 7
            VDG+ST
Sbjct: 1162 VDGVST 1167



>XP_005276812
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           I +GI+TR+
Sbjct: 905 IANGIATRL 913



>XP_006713491
          Length = 1425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           I +GI+TR+
Sbjct: 823 IANGIATRL 831



>XP_005276811
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           I +GI+TR+
Sbjct: 905 IANGIATRL 913



>XP_006713490
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           I +GI+TR+
Sbjct: 905 IANGIATRL 913



>XP_005276810
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           I +GI+TR+
Sbjct: 905 IANGIATRL 913



>XP_005276809
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           I +GI+TR+
Sbjct: 905 IANGIATRL 913



>XP_006713489
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           I +GI+TR+
Sbjct: 905 IANGIATRL 913



>XP_005276808
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IVDGISTRM 9
           I +GI+TR+
Sbjct: 905 IANGIATRL 913



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.142    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 410,376
Number of extensions: 575
Number of successful extensions: 32
Number of sequences better than 10000.0: 32
Number of HSP's gapped: 32
Number of HSP's successfully gapped: 32
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)