Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              18    1935
XP_005250103                                                           18    1935
XP_005250102                                                           18    1935
NP_000050                                                              17    4312
NP_001274744                                                           16    7355
NP_001120792                                                           16    7355
NP_001274745                                                           16    7355
NP_055662                                                              16    7355
NP_653080                                                              16    7355
XP_005267291                                                           16    7355
XP_006711752                                                           16    7355
XP_006711750                                                           16    7355
XP_006711749                                                           16    7355
XP_005245731                                                           16    7355
XP_005245730                                                           16    7355
XP_005245729                                                           16    7355
XP_005245727                                                           16    7355
XP_005245726                                                           16    7355
XP_005245725                                                           16    7355
XP_005245724                                                           16    7355
XP_005245715                                                           16    7355
XP_006711748                                                           16    7355
XP_006711747                                                           16    7355
XP_006711746                                                           16    7355
XP_006711745                                                           16    7355
XP_006711744                                                           16    7355
XP_006711743                                                           16    7355
XP_006711742                                                           16    7355
NP_002401                                                              15    9605
NP_795352                                                              15    9605
NP_055026                                                              15    9605
XP_005265931                                                           15    9605
XP_005265930                                                           15    9605
XP_005265929                                                           15    9605
XP_005263727                                                           15    9605
XP_005263726                                                           15    9605
XP_006712598                                                           15    9605
XP_005263725                                                           15    9605
XP_006712597                                                           15    9605
XP_005263723                                                           15    9605
XP_005245867                                                           15    9605
XP_006710340                                                           15    9605
XP_005270398                                                           15    9605
XP_006710339                                                           15    9605
XP_006710338                                                           15    9605
NP_000929                                                              15    9605
NP_057132                                                              15    9605
NP_001276                                                              15    9605
>NP_004324
          Length = 766

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ITVGQRIVS 9
           ITVGQRI S
Sbjct: 457 ITVGQRIGS 465
>XP_005250103
          Length = 758

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ITVGQRIVS 9
           ITVGQRI S
Sbjct: 457 ITVGQRIGS 465
>XP_005250102
          Length = 767

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ITVGQRIVS 9
           ITVGQRI S
Sbjct: 457 ITVGQRIGS 465
>NP_000050
          Length = 3418

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    ITVGQRIV 8
            +TVGQ+I+
Sbjct: 2745 LTVGQKII 2752
>NP_001274744
          Length = 976

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 269 ITAGQRI 275
>NP_001120792
          Length = 983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 276 ITAGQRI 282
>NP_001274745
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>NP_055662
          Length = 1087

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 276 ITAGQRI 282
>NP_653080
          Length = 1684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  ITVGQR 6
          ITVGQR
Sbjct: 7  ITVGQR 12
>XP_005267291
          Length = 1684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  ITVGQR 6
          ITVGQR
Sbjct: 7  ITVGQR 12
>XP_006711752
          Length = 1085

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 276 ITAGQRI 282
>XP_006711750
          Length = 930

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  ITVGQRI 7
          IT GQRI
Sbjct: 46 ITAGQRI 52
>XP_006711749
          Length = 965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  ITVGQRI 7
          IT GQRI
Sbjct: 81 ITAGQRI 87
>XP_005245731
          Length = 983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 276 ITAGQRI 282
>XP_005245730
          Length = 994

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>XP_005245729
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 276 ITAGQRI 282
>XP_005245727
          Length = 1079

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>XP_005245726
          Length = 1095

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>XP_005245725
          Length = 1096

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>XP_005245724
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>XP_005245715
          Length = 1115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>XP_006711748
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 276 ITAGQRI 282
>XP_006711747
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 276 ITAGQRI 282
>XP_006711746
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 276 ITAGQRI 282
>XP_006711745
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>XP_006711744
          Length = 1171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>XP_006711743
          Length = 1171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>XP_006711742
          Length = 1171

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ITVGQRI 7
           IT GQRI
Sbjct: 287 ITAGQRI 293
>NP_002401
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TVGQRIV 8
           TVG RIV
Sbjct: 340 TVGDRIV 346
>NP_795352
          Length = 1801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ITVGQRIVS 9
            + VG RIVS
Sbjct: 1721 LKVGDRIVS 1729
>NP_055026
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ITVGQRIV 8
           +TVG R++
Sbjct: 133 VTVGNRLI 140
>XP_005265931
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ITVGQRIV 8
           +TVG R++
Sbjct: 133 VTVGNRLI 140
>XP_005265930
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ITVGQRIV 8
           +TVG R++
Sbjct: 133 VTVGNRLI 140
>XP_005265929
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  ITVGQRIV 8
          +TVG R++
Sbjct: 54 VTVGNRLI 61
>XP_005263727
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TVGQRIV 8
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_005263726
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TVGQRIV 8
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_006712598
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TVGQRIV 8
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_005263725
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TVGQRIV 8
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_006712597
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TVGQRIV 8
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_005263723
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TVGQRIV 8
           TVG RIV
Sbjct: 340 TVGDRIV 346
>XP_005245867
          Length = 1201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   ITVGQRIV 8
           ++VGQR++
Sbjct: 155 VSVGQRVL 162
>XP_006710340
          Length = 1815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ITVGQRIVS 9
            + VG RIVS
Sbjct: 1735 LKVGDRIVS 1743
>XP_005270398
          Length = 1882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ITVGQRIVS 9
            + VG RIVS
Sbjct: 1721 LKVGDRIVS 1729
>XP_006710339
          Length = 1896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ITVGQRIVS 9
            + VG RIVS
Sbjct: 1735 LKVGDRIVS 1743
>XP_006710338
          Length = 1896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ITVGQRIVS 9
            + VG RIVS
Sbjct: 1735 LKVGDRIVS 1743
>NP_000929
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VGQRIVS 9
           +GQRIV+
Sbjct: 252 IGQRIVA 258
>NP_057132
          Length = 298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ITVGQRIV 8
           I+VGQR++
Sbjct: 137 ISVGQRLL 144
>NP_001276
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ITVGQRIV 8
           + +GQRIV
Sbjct: 300 LQIGQRIV 307
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.140    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 431,976
Number of extensions: 552
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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