Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              20     509
XP_005273257                                                           20     509
NP_001155018                                                           17    3301
NP_001268451                                                           17    3301
NP_001268449                                                           17    3301
NP_877954                                                              17    3301
NP_001268450                                                           17    3301
NP_115874                                                              17    3301
NP_001229313                                                           17    3301
NP_001229323                                                           17    3301
XP_005267279                                                           17    3301
XP_006715674                                                           17    3301
XP_005267275                                                           17    3301
XP_006715673                                                           17    3301
XP_005267272                                                           17    3301
XP_005267274                                                           17    3301
XP_006715669                                                           17    3301
XP_006715668                                                           17    3301
XP_005267271                                                           17    3301
NP_001006608                                                           17    4312
NP_055649                                                              17    4312
XP_005257941                                                           17    4312
XP_005257940                                                           17    4312
XP_006722274                                                           17    4312
XP_006722273                                                           17    4312
XP_005257939                                                           17    4312
XP_006722272                                                           17    4312
XP_005257937                                                           17    4312
XP_005257936                                                           17    4312
XP_005257935                                                           17    4312
XP_006722271                                                           17    4312
NP_001360                                                              16    5631
XP_005248319                                                           16    5631
NP_001005476                                                           16    5631
NP_003619                                                              16    5631
NP_065899                                                              16    7355
NP_001136018                                                           16    7355
NP_055736                                                              16    7355
NP_001008701                                                           16    7355
NP_361013                                                              16    7355
XP_005259876                                                           16    7355
XP_006722752                                                           16    7355
XP_005259875                                                           16    7355
XP_006722751                                                           16    7355
XP_005252606                                                           16    7355
NP_001189394                                                           15    9605
NP_001189393                                                           15    9605
NP_006615                                                              15    9605
NP_001189395                                                           15    9605
NP_001189396                                                           15    9605
NP_997644                                                              15    9605
NP_001189397                                                           15    9605
NP_003441                                                              15    9605
XP_005252420                                                           15    9605
XP_006717439                                                           15    9605
XP_005252419                                                           15    9605
XP_005252418                                                           15    9605
XP_005252417                                                           15    9605
XP_005252416                                                           15    9605
XP_006710322                                                           15    9605
>NP_064450
          Length = 1722

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TTRQLSSP 9
           TTRQLSSP
Sbjct: 422 TTRQLSSP 429
>XP_005273257
          Length = 1726

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TTRQLSSP 9
           TTRQLSSP
Sbjct: 422 TTRQLSSP 429
>NP_001155018
          Length = 1015

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TTRQLSSP 9
           TTR++SSP
Sbjct: 421 TTRRVSSP 428
>NP_001268451
          Length = 793

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ITTRQLSS 8
           ITTRQL S
Sbjct: 661 ITTRQLES 668
>NP_001268449
          Length = 840

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ITTRQLSS 8
           ITTRQL S
Sbjct: 708 ITTRQLES 715
>NP_877954
          Length = 824

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ITTRQLSS 8
           ITTRQL S
Sbjct: 692 ITTRQLES 699
>NP_001268450
          Length = 880

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ITTRQLSS 8
           ITTRQL S
Sbjct: 748 ITTRQLES 755
>NP_115874
          Length = 840

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   ITTRQLSS 8
           ITTRQL S
Sbjct: 708 ITTRQLES 715
>NP_001229313
          Length = 610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ITTRQLSSP 9
           +TTR++S+P
Sbjct: 237 VTTRKVSAP 245
>NP_001229323
          Length = 610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ITTRQLSSP 9
           +TTR++S+P
Sbjct: 237 VTTRKVSAP 245
>XP_005267279
          Length = 404

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  ITTRQLSSP 9
          +TTR++S+P
Sbjct: 31 VTTRKVSAP 39
>XP_006715674
          Length = 404

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  ITTRQLSSP 9
          +TTR++S+P
Sbjct: 31 VTTRKVSAP 39
>XP_005267275
          Length = 404

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  ITTRQLSSP 9
          +TTR++S+P
Sbjct: 31 VTTRKVSAP 39
>XP_006715673
          Length = 404

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  ITTRQLSSP 9
          +TTR++S+P
Sbjct: 31 VTTRKVSAP 39
>XP_005267272
          Length = 610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ITTRQLSSP 9
           +TTR++S+P
Sbjct: 237 VTTRKVSAP 245
>XP_005267274
          Length = 610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ITTRQLSSP 9
           +TTR++S+P
Sbjct: 237 VTTRKVSAP 245
>XP_006715669
          Length = 610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ITTRQLSSP 9
           +TTR++S+P
Sbjct: 237 VTTRKVSAP 245
>XP_006715668
          Length = 610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ITTRQLSSP 9
           +TTR++S+P
Sbjct: 237 VTTRKVSAP 245
>XP_005267271
          Length = 610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   ITTRQLSSP 9
           +TTR++S+P
Sbjct: 237 VTTRKVSAP 245
>NP_001006608
          Length = 1700

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>NP_055649
          Length = 1700

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>XP_005257941
          Length = 969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>XP_005257940
          Length = 1018

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>XP_006722274
          Length = 1576

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>XP_006722273
          Length = 1600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>XP_005257939
          Length = 1606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TRQLSSP 9
          TRQLS+P
Sbjct: 73 TRQLSTP 79
>XP_006722272
          Length = 1635

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>XP_005257937
          Length = 1651

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>XP_005257936
          Length = 1665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>XP_005257935
          Length = 1676

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>XP_006722271
          Length = 1700

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TRQLSSP 9
           TRQLS+P
Sbjct: 167 TRQLSTP 173
>NP_001360
          Length = 4624

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ITTRQLSS 8
            +TTR LSS
Sbjct: 1873 VTTRDLSS 1880
>XP_005248319
          Length = 4609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    ITTRQLSS 8
            +TTR LSS
Sbjct: 1858 VTTRDLSS 1865
>NP_001005476
          Length = 1149

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITTRQLSSP 9
           +T+RQ S+P
Sbjct: 291 VTSRQTSNP 299
>NP_003619
          Length = 1192

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITTRQLSSP 9
           +T+RQ S+P
Sbjct: 291 VTSRQTSNP 299
>NP_065899
          Length = 1359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTRQLSSP 9
           T RQ+SSP
Sbjct: 537 TGRQVSSP 544
>NP_001136018
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITTRQLSSP 9
           ++ RQ+SSP
Sbjct: 416 LSNRQVSSP 424
>NP_055736
          Length = 1469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TTRQLSSP 9
            T+R LSSP
Sbjct: 1366 TSRPLSSP 1373
>NP_001008701
          Length = 1474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TTRQLSSP 9
            T+R LSSP
Sbjct: 1371 TSRPLSSP 1378
>NP_361013
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITTRQLSSP 9
           ++ RQ+SSP
Sbjct: 416 LSNRQVSSP 424
>XP_005259876
          Length = 1498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TTRQLSSP 9
            T+R LSSP
Sbjct: 1395 TSRPLSSP 1402
>XP_006722752
          Length = 1462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TTRQLSSP 9
            T+R LSSP
Sbjct: 1359 TSRPLSSP 1366
>XP_005259875
          Length = 1493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TTRQLSSP 9
            T+R LSSP
Sbjct: 1390 TSRPLSSP 1397
>XP_006722751
          Length = 1498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TTRQLSSP 9
            T+R LSSP
Sbjct: 1395 TSRPLSSP 1402
>XP_005252606
          Length = 1221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTRQLSSP 9
           T RQ+SSP
Sbjct: 399 TGRQVSSP 406
>NP_001189394
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>NP_001189393
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>NP_006615
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>NP_001189395
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>NP_001189396
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>NP_997644
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>NP_001189397
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>NP_003441
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITTRQLSSP 9
           ++ RQ+SSP
Sbjct: 259 LSRRQVSSP 267
>XP_005252420
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>XP_006717439
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>XP_005252419
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>XP_005252418
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>XP_005252417
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>XP_005252416
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTRQLS 7
          TTRQLS
Sbjct: 52 TTRQLS 57
>XP_006710322
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ITTRQLSSP 9
           ITT  LSSP
Sbjct: 322 ITTLCLSSP 330
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.117    0.301 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,210
Number of extensions: 983
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package