Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004651                                                              17    4312
NP_001116137                                                           17    4312
NP_001347                                                              17    4312
NP_001180346                                                           17    4312
NP_001180345                                                           17    4312
NP_037518                                                              17    4312
NP_998816                                                              17    4312
NP_001119580                                                           17    4312
NP_000330                                                              17    4312
NP_001119579                                                           17    4312
XP_006724941                                                           17    4312
XP_005262621                                                           17    4312
XP_006724940                                                           17    4312
XP_005256176                                                           17    4312
NP_001010854                                                           16    5631
XP_005267424                                                           16    5631
XP_006720122                                                           16    5631
XP_006720121                                                           16    5631
NP_001158220                                                           16    7355
NP_001158219                                                           16    7355
NP_009142                                                              16    7355
NP_001158218                                                           16    7355
XP_006719091                                                           16    7355
XP_006719090                                                           16    7355
NP_079035                                                              15    9605
NP_742068                                                              15    9605
NP_997205                                                              15    9605
NP_001007596                                                           15    9605
NP_001165906                                                           15    9605
NP_036365                                                              15    9605
XP_005251128                                                           15    9605
XP_005251127                                                           15    9605
XP_005251126                                                           15    9605
XP_006711246                                                           15    9605
XP_005244978                                                           15    9605
XP_005244977                                                           15    9605
XP_005244976                                                           15    9605
XP_005244975                                                           15    9605
NP_061160                                                              15    9605
>NP_004651
          Length = 660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           I LAVGR G
Sbjct: 399 IFLAVGRVG 407
>NP_001116137
          Length = 660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           I LAVGR G
Sbjct: 399 IFLAVGRVG 407
>NP_001347
          Length = 662

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           I LAVGR G
Sbjct: 401 IFLAVGRVG 409
>NP_001180346
          Length = 646

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           I LAVGR G
Sbjct: 385 IFLAVGRVG 393
>NP_001180345
          Length = 661

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           I LAVGR G
Sbjct: 401 IFLAVGRVG 409
>NP_037518
          Length = 477

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LAVGRTG 9
           LAVG+TG
Sbjct: 316 LAVGKTG 322
>NP_998816
          Length = 458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LAVGRTG 9
           LAVG+TG
Sbjct: 297 LAVGKTG 303
>NP_001119580
          Length = 1021

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           ITL +GR G
Sbjct: 975 ITLPIGRKG 983
>NP_000330
          Length = 1030

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           ITL +GR G
Sbjct: 984 ITLPIGRKG 992
>NP_001119579
          Length = 1029

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           ITL +GR G
Sbjct: 983 ITLPIGRKG 991
>XP_006724941
          Length = 637

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           I LAVGR G
Sbjct: 399 IFLAVGRVG 407
>XP_005262621
          Length = 657

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           I LAVGR G
Sbjct: 396 IFLAVGRVG 404
>XP_006724940
          Length = 660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           I LAVGR G
Sbjct: 399 IFLAVGRVG 407
>XP_005256176
          Length = 1020

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           ITL +GR G
Sbjct: 974 ITLPIGRKG 982
>NP_001010854
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +T+A+GR G
Sbjct: 369 LTIALGRRG 377
>XP_005267424
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +T+A+GR G
Sbjct: 111 LTIALGRRG 119
>XP_006720122
          Length = 820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +T+A+GR G
Sbjct: 275 LTIALGRRG 283
>XP_006720121
          Length = 851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +T+A+GR G
Sbjct: 377 LTIALGRRG 385
>NP_001158220
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AVGRTG 9
          A+GRTG
Sbjct: 33 AIGRTG 38
>NP_001158219
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AVGRTG 9
          A+GRTG
Sbjct: 33 AIGRTG 38
>NP_009142
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AVGRTG 9
          A+GRTG
Sbjct: 33 AIGRTG 38
>NP_001158218
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AVGRTG 9
          A+GRTG
Sbjct: 33 AIGRTG 38
>XP_006719091
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AVGRTG 9
          A+GRTG
Sbjct: 33 AIGRTG 38
>XP_006719090
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AVGRTG 9
          A+GRTG
Sbjct: 33 AIGRTG 38
>NP_079035
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           + +AVG TG
Sbjct: 95  LLMAVGETG 103
>NP_742068
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +T+A+ RTG
Sbjct: 337 LTIALQRTG 345
>NP_997205
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TLAVGRTG 9
           T+A+GR G
Sbjct: 247 TVALGRAG 254
>NP_001007596
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TLAVGRTG 9
           T+A+GR G
Sbjct: 242 TVALGRAG 249
>NP_001165906
          Length = 988

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +++A+G TG
Sbjct: 152 VSIALGNTG 160
>NP_036365
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +++A+G TG
Sbjct: 152 VSIALGNTG 160
>XP_005251128
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           + +AVG TG
Sbjct: 193 LLMAVGETG 201
>XP_005251127
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           + +AVG TG
Sbjct: 193 LLMAVGETG 201
>XP_005251126
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ITLAVGRTG 9
           + +AVG TG
Sbjct: 193 LLMAVGETG 201
>XP_006711246
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +T+A+ RTG
Sbjct: 337 LTIALQRTG 345
>XP_005244978
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +T+A+ RTG
Sbjct: 337 LTIALQRTG 345
>XP_005244977
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +T+A+ RTG
Sbjct: 337 LTIALQRTG 345
>XP_005244976
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +T+A+ RTG
Sbjct: 337 LTIALQRTG 345
>XP_005244975
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ITLAVGRTG 9
           +T+A+ RTG
Sbjct: 337 LTIALQRTG 345
>NP_061160
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LAVGRTG 9
          +AVG+TG
Sbjct: 50 VAVGKTG 56
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.142    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 419,205
Number of extensions: 616
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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