Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              19     869
NP_001120972                                                           19     869
XP_006716054                                                           19     869
XP_006716053                                                           19     869
XP_006716052                                                           19     869
XP_006716051                                                           19     869
NP_001157915                                                           17    4312
NP_057664                                                              16    5631
NP_036516                                                              16    7355
NP_653267                                                              16    7355
NP_005877                                                              16    7355
NP_079130                                                              16    7355
NP_001136336                                                           16    7355
XP_006723839                                                           16    7355
XP_005260259                                                           16    7355
XP_006721417                                                           16    7355
XP_006721416                                                           16    7355
XP_006721186                                                           16    7355
XP_005255829                                                           16    7355
XP_006721185                                                           16    7355
XP_006721184                                                           16    7355
XP_006719216                                                           16    7355
NP_001139669                                                           16    7355
NP_775082                                                              15    9605
NP_003377                                                              15    9605
NP_006786                                                              15    9605
NP_001269373                                                           15    9605
NP_976224                                                              15    9605
NP_443132                                                              15    9605
NP_937757                                                              15    9605
NP_937756                                                              15    9605
NP_872393                                                              15    9605
NP_001269374                                                           15    9605
XP_005254432                                                           15    9605
XP_006720566                                                           15    9605
XP_006718487                                                           15    9605
XP_006712515                                                           15    9605
XP_006712514                                                           15    9605
XP_006712513                                                           15    9605
XP_006712512                                                           15    9605
XP_006712511                                                           15    9605
XP_006712510                                                           15    9605
XP_006712509                                                           15    9605
XP_005246533                                                           15    9605
XP_006712508                                                           15    9605
NP_115893                                                              15    9605
>NP_000236
          Length = 1390

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISSTVLGKL 9
           ISSTVLGK+
Sbjct: 915 ISSTVLGKV 923
>NP_001120972
          Length = 1408

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISSTVLGKL 9
           ISSTVLGK+
Sbjct: 933 ISSTVLGKV 941
>XP_006716054
          Length = 960

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISSTVLGKL 9
           ISSTVLGK+
Sbjct: 485 ISSTVLGKV 493
>XP_006716053
          Length = 960

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISSTVLGKL 9
           ISSTVLGK+
Sbjct: 485 ISSTVLGKV 493
>XP_006716052
          Length = 1409

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISSTVLGKL 9
           ISSTVLGK+
Sbjct: 934 ISSTVLGKV 942
>XP_006716051
          Length = 1427

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISSTVLGKL 9
           ISSTVLGK+
Sbjct: 952 ISSTVLGKV 960
>NP_001157915
          Length = 1873

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    ISSTVLGKL 9
            +SS V+GKL
Sbjct: 1577 VSSPVIGKL 1585
>NP_057664
          Length = 1184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SSTVLGKL 9
          S TV+GKL
Sbjct: 42 SGTVIGKL 49
>NP_036516
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ISSTVLGK 8
           + STVLGK
Sbjct: 405 LPSTVLGK 412
>NP_653267
          Length = 4753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    ISSTVLG 7
            +SSTVLG
Sbjct: 4019 LSSTVLG 4025
>NP_005877
          Length = 655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISSTVLGK 8
          +SS VLGK
Sbjct: 23 VSSLVLGK 30
>NP_079130
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  SSTVLGK 8
          SST+LGK
Sbjct: 69 SSTMLGK 75
>NP_001136336
          Length = 2521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISSTVLGKL 9
            +  TVLGKL
Sbjct: 2023 LRKTVLGKL 2031
>XP_006723839
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ISSTVLGK 8
           + STVLGK
Sbjct: 327 LPSTVLGK 334
>XP_005260259
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ISSTVLGK 8
           + STVLGK
Sbjct: 405 LPSTVLGK 412
>XP_006721417
          Length = 2497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISSTVLGKL 9
            +  TVLGKL
Sbjct: 1999 LRKTVLGKL 2007
>XP_006721416
          Length = 2504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISSTVLGKL 9
            +  TVLGKL
Sbjct: 2006 LRKTVLGKL 2014
>XP_006721186
          Length = 658

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISSTVLGK 8
          +SS VLGK
Sbjct: 23 VSSLVLGK 30
>XP_005255829
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISSTVLGK 8
          +SS VLGK
Sbjct: 23 VSSLVLGK 30
>XP_006721185
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISSTVLGK 8
          +SS VLGK
Sbjct: 23 VSSLVLGK 30
>XP_006721184
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISSTVLGK 8
          +SS VLGK
Sbjct: 23 VSSLVLGK 30
>XP_006719216
          Length = 259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  SSTVLGK 8
          SST+LGK
Sbjct: 69 SSTMLGK 75
>NP_001139669
          Length = 7081

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    ISSTVLGK 8
            ISS VLGK
Sbjct: 3063 ISSHVLGK 3070
>NP_775082
          Length = 2721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISSTVLGKL 9
            +SST  GKL
Sbjct: 1279 VSSTYSGKL 1287
>NP_003377
          Length = 2812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISSTVLGKL 9
            +SST  GKL
Sbjct: 1279 VSSTYSGKL 1287
>NP_006786
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISSTVLGKL 9
           + +TVLGK+
Sbjct: 476 LPNTVLGKI 484
>NP_001269373
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISSTVLGKL 9
           + +TVLGK+
Sbjct: 476 LPNTVLGKI 484
>NP_976224
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   STVLGK 8
           STVLGK
Sbjct: 247 STVLGK 252
>NP_443132
          Length = 3538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SSTVLGKL 9
            +STV+G+L
Sbjct: 2070 TSTVIGRL 2077
>NP_937757
          Length = 3667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SSTVLGKL 9
            +STV+G+L
Sbjct: 2134 TSTVIGRL 2141
>NP_937756
          Length = 3707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SSTVLGKL 9
            +STV+G+L
Sbjct: 2174 TSTVIGRL 2181
>NP_872393
          Length = 3234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
>NP_001269374
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISSTVLGKL 9
           + +TVLGK+
Sbjct: 490 LPNTVLGKI 498
>XP_005254432
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  STVLGK 8
          STVLGK
Sbjct: 64 STVLGK 69
>XP_006720566
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   STVLGK 8
           STVLGK
Sbjct: 247 STVLGK 252
>XP_006718487
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISSTVLGKL 9
           + +TVLGK+
Sbjct: 476 LPNTVLGKI 484
>XP_006712515
          Length = 3232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
>XP_006712514
          Length = 2496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
>XP_006712513
          Length = 3220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
>XP_006712512
          Length = 3237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
>XP_006712511
          Length = 3256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
>XP_006712510
          Length = 3305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
>XP_006712509
          Length = 3319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
>XP_005246533
          Length = 3323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
>XP_006712508
          Length = 3324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
>NP_115893
          Length = 3258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   STVLGKL 9
           +T+LGKL
Sbjct: 514 TTILGKL 520
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.131    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 384,530
Number of extensions: 467
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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