Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     869
XP_006718907                                                           19     869
XP_006718906                                                           19     869
XP_005271619                                                           19     869
XP_005271618                                                           19     869
NP_055085                                                              18    1135
NP_001229965                                                           18    1135
NP_001119807                                                           18    1135
XP_006723055                                                           18    1135
XP_005258525                                                           18    1135
NP_443192                                                              17    4312
NP_689823                                                              16    5631
NP_115946                                                              16    5631
NP_004925                                                              16    5631
NP_001161139                                                           16    5631
NP_001277255                                                           16    5631
NP_001277254                                                           16    5631
NP_001271226                                                           16    5631
NP_001013863                                                           16    5631
NP_060190                                                              16    5631
NP_065849                                                              16    5631
NP_001271227                                                           16    5631
XP_005259649                                                           16    5631
XP_006722855                                                           16    5631
XP_006722854                                                           16    5631
XP_006722853                                                           16    5631
XP_005254507                                                           16    5631
XP_005254506                                                           16    5631
XP_005254505                                                           16    5631
XP_006720635                                                           16    5631
XP_006720634                                                           16    5631
XP_006714500                                                           16    5631
XP_006714499                                                           16    5631
XP_006714498                                                           16    5631
XP_005248285                                                           16    5631
NP_004564                                                              16    5631
NP_620168                                                              16    7355
NP_001013754                                                           16    7355
NP_001123487                                                           16    7355
NP_872414                                                              16    7355
NP_001171473                                                           16    7355
NP_002579                                                              16    7355
NP_115778                                                              16    7355
XP_006722719                                                           16    7355
XP_006722718                                                           16    7355
XP_006722717                                                           16    7355
XP_005268890                                                           16    7355
XP_006719434                                                           16    7355
XP_005273481                                                           16    7355
NP_001027006                                                           16    7355
NP_996816                                                              15    9605
NP_004130                                                              15    9605
NP_775105                                                              15    9605
NP_001036148                                                           15    9605
XP_006715506                                                           15    9605
XP_006715505                                                           15    9605
XP_006715504                                                           15    9605
XP_006715503                                                           15    9605
XP_006715502                                                           15    9605
>NP_000042
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           ISSLV YFI
Sbjct: 97  ISSLVKYFI 105
>XP_006718907
          Length = 3050

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           ISSLV YFI
Sbjct: 97  ISSLVKYFI 105
>XP_006718906
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           ISSLV YFI
Sbjct: 97  ISSLVKYFI 105
>XP_005271619
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           ISSLV YFI
Sbjct: 97  ISSLVKYFI 105
>XP_005271618
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           ISSLV YFI
Sbjct: 97  ISSLVKYFI 105
>NP_055085
          Length = 487

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   ISSLVNYF 8
           I+SLVNYF
Sbjct: 371 INSLVNYF 378
>NP_001229965
          Length = 487

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   ISSLVNYF 8
           I+SLVNYF
Sbjct: 371 INSLVNYF 378
>NP_001119807
          Length = 487

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   ISSLVNYF 8
           I+SLVNYF
Sbjct: 371 INSLVNYF 378
>XP_006723055
          Length = 260

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   ISSLVNYF 8
           I+SLVNYF
Sbjct: 144 INSLVNYF 151
>XP_005258525
          Length = 278

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   ISSLVNYF 8
           I+SLVNYF
Sbjct: 162 INSLVNYF 169
>NP_443192
          Length = 134

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  SSLVNYFI 9
          SSL NYF+
Sbjct: 56 SSLRNYFV 63
>NP_689823
          Length = 623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ISSLVNY 7
           +SSL+NY
Sbjct: 424 LSSLINY 430
>NP_115946
          Length = 1042

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           ++ L+NYF+
Sbjct: 718 VTDLLNYFL 726
>NP_004925
          Length = 790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSLVNYFI 9
           +SLV YFI
Sbjct: 414 NSLVRYFI 421
>NP_001161139
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSLVNYFI 9
           +SLV YFI
Sbjct: 414 NSLVRYFI 421
>NP_001277255
          Length = 587

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           ++ L+NYF+
Sbjct: 263 VTDLLNYFL 271
>NP_001277254
          Length = 1004

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           ++ L+NYF+
Sbjct: 718 VTDLLNYFL 726
>NP_001271226
          Length = 1181

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISSLVNY 7
           +SSLVNY
Sbjct: 542 MSSLVNY 548
>NP_001013863
          Length = 403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           + ++VNYF+
Sbjct: 226 LDAVVNYFV 234
>NP_060190
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           + ++VNYF+
Sbjct: 226 LDAVVNYFV 234
>NP_065849
          Length = 1018

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ISSLVNYFI 9
           +  LVNYF+
Sbjct: 761 VLDLVNYFL 769
>NP_001271227
          Length = 1170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISSLVNY 7
           +SSLVNY
Sbjct: 546 MSSLVNY 552
>XP_005259649
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           + ++VNYF+
Sbjct: 303 LDAVVNYFV 311
>XP_006722855
          Length = 481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           + ++VNYF+
Sbjct: 258 LDAVVNYFV 266
>XP_006722854
          Length = 525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           + ++VNYF+
Sbjct: 303 LDAVVNYFV 311
>XP_006722853
          Length = 526

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           + ++VNYF+
Sbjct: 303 LDAVVNYFV 311
>XP_005254507
          Length = 1070

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISSLVNY 7
           +SSLVNY
Sbjct: 546 MSSLVNY 552
>XP_005254506
          Length = 1123

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISSLVNY 7
           +SSLVNY
Sbjct: 546 MSSLVNY 552
>XP_005254505
          Length = 1124

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISSLVNY 7
           +SSLVNY
Sbjct: 546 MSSLVNY 552
>XP_006720635
          Length = 1125

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISSLVNY 7
           +SSLVNY
Sbjct: 546 MSSLVNY 552
>XP_006720634
          Length = 1184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISSLVNY 7
           +SSLVNY
Sbjct: 546 MSSLVNY 552
>XP_006714500
          Length = 575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSLVNYFI 9
           +SLV YFI
Sbjct: 414 NSLVRYFI 421
>XP_006714499
          Length = 575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSLVNYFI 9
           +SLV YFI
Sbjct: 414 NSLVRYFI 421
>XP_006714498
          Length = 790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSLVNYFI 9
           +SLV YFI
Sbjct: 414 NSLVRYFI 421
>XP_005248285
          Length = 790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SSLVNYFI 9
           +SLV YFI
Sbjct: 414 NSLVRYFI 421
>NP_004564
          Length = 1185

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISSLVNY 7
           +SSLVNY
Sbjct: 546 MSSLVNY 552
>NP_620168
          Length = 1300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SSLVNYFI 9
            +SLVN+F+
Sbjct: 1089 TSLVNFFM 1096
>NP_001013754
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISSLVNYF 8
           +S L+NYF
Sbjct: 373 VSILLNYF 380
>NP_001123487
          Length = 272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  ISSLVNYFI 9
          +S L+NY++
Sbjct: 46 VSLLLNYYV 54
>NP_872414
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           +S L+NY++
Sbjct: 181 VSLLLNYYV 189
>NP_001171473
          Length = 1263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SSLVNYFI 9
            +SLVN+F+
Sbjct: 1052 TSLVNFFM 1059
>NP_002579
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSLVNYF 8
           SSL NYF
Sbjct: 401 SSLKNYF 407
>NP_115778
          Length = 863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SSLVNYF 8
           SSL NYF
Sbjct: 401 SSLKNYF 407
>XP_006722719
          Length = 1224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SSLVNYFI 9
            +SLVN+F+
Sbjct: 1013 TSLVNFFM 1020
>XP_006722718
          Length = 1310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SSLVNYFI 9
            +SLVN+F+
Sbjct: 1099 TSLVNFFM 1106
>XP_006722717
          Length = 1310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SSLVNYFI 9
            +SLVN+F+
Sbjct: 1099 TSLVNFFM 1106
>XP_005268890
          Length = 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  ISSLVNYFI 9
          +S L+NY++
Sbjct: 46 VSLLLNYYV 54
>XP_006719434
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           +S L+NY++
Sbjct: 129 VSLLLNYYV 137
>XP_005273481
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISSLVNYFI 9
           I SL+ YFI
Sbjct: 114 IGSLIIYFI 122
>NP_001027006
          Length = 1149

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISSLVNYFI 9
           I SL+ YFI
Sbjct: 114 IGSLIIYFI 122
>NP_996816
          Length = 5202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    LVNYFI 9
            ++NYFI
Sbjct: 3897 IINYFI 3902
>NP_004130
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISSLVNYFI 9
           + +L+NY+I
Sbjct: 424 LEALLNYYI 432
>NP_775105
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVNYFI 9
           +VNYFI
Sbjct: 407 VVNYFI 412
>NP_001036148
          Length = 1683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVNYFI 9
           +VNYFI
Sbjct: 407 VVNYFI 412
>XP_006715506
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVNYFI 9
           +VNYFI
Sbjct: 407 VVNYFI 412
>XP_006715505
          Length = 1673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVNYFI 9
           +VNYFI
Sbjct: 407 VVNYFI 412
>XP_006715504
          Length = 1683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVNYFI 9
           +VNYFI
Sbjct: 407 VVNYFI 412
>XP_006715503
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVNYFI 9
           +VNYFI
Sbjct: 407 VVNYFI 412
>XP_006715502
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LVNYFI 9
           +VNYFI
Sbjct: 407 VVNYFI 412
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.148    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 431,074
Number of extensions: 625
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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