Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              18    1135
NP_116213                                                              18    1935
XP_005263884                                                           18    1935
XP_006712870                                                           18    1935
NP_110414                                                              16    5631
NP_001726                                                              16    5631
NP_001129477                                                           16    5631
NP_001129478                                                           16    5631
NP_055495                                                              16    5631
NP_000810                                                              16    5631
XP_006724053                                                           16    5631
XP_006724052                                                           16    5631
XP_005260998                                                           16    5631
XP_006724051                                                           16    5631
XP_006722261                                                           16    5631
XP_005258130                                                           16    5631
NP_780294                                                              16    5631
NP_001231892                                                           16    7355
NP_001104488                                                           16    7355
NP_689760                                                              16    7355
NP_660093                                                              16    7355
NP_065831                                                              16    7355
NP_892009                                                              16    7355
NP_001171019                                                           16    7355
NP_001171020                                                           16    7355
NP_001236                                                              16    7355
NP_942143                                                              16    7355
NP_001171018                                                           16    7355
NP_942142                                                              16    7355
XP_006718429                                                           16    7355
XP_006718428                                                           16    7355
XP_006718427                                                           16    7355
XP_005265881                                                           16    7355
XP_006714888                                                           16    7355
XP_006714887                                                           16    7355
XP_006714886                                                           16    7355
NP_004855                                                              15    9605
NP_003821                                                              15    9605
NP_001274745                                                           15    9605
NP_055662                                                              15    9605
NP_002536                                                              15    9605
NP_001012393                                                           15    9605
NP_852111                                                              15    9605
NP_000136                                                              15    9605
NP_775871                                                              15    9605
NP_005796                                                              15    9605
XP_006723231                                                           15    9605
XP_005258877                                                           15    9605
XP_005258876                                                           15    9605
XP_005253680                                                           15    9605
XP_005271636                                                           15    9605
XP_005271635                                                           15    9605
XP_005271632                                                           15    9605
XP_006718909                                                           15    9605
XP_005271631                                                           15    9605
XP_006711752                                                           15    9605
XP_006711751                                                           15    9605
XP_006711750                                                           15    9605
XP_006711749                                                           15    9605
XP_005245729                                                           15    9605
XP_005245727                                                           15    9605
XP_005245726                                                           15    9605
XP_005245725                                                           15    9605
XP_005245724                                                           15    9605
XP_005245715                                                           15    9605
XP_006711748                                                           15    9605
XP_006711747                                                           15    9605
XP_006711746                                                           15    9605
XP_006711745                                                           15    9605
XP_006711744                                                           15    9605
XP_006711743                                                           15    9605
XP_006711742                                                           15    9605
NP_054756                                                              15    9605
>NP_004110
          Length = 993

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISNTGVSIQ 9
           IS TGVSIQ
Sbjct: 632 ISKTGVSIQ 640
>NP_116213
          Length = 555

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ISNTGVSIQ 9
           ISNTG+S Q
Sbjct: 273 ISNTGLSTQ 281
>XP_005263884
          Length = 554

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ISNTGVSIQ 9
           ISNTG+S Q
Sbjct: 272 ISNTGLSTQ 280
>XP_006712870
          Length = 555

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ISNTGVSIQ 9
           ISNTG+S Q
Sbjct: 273 ISNTGLSTQ 281
>NP_110414
          Length = 569

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISNTGVSIQ 9
           I NTG S+Q
Sbjct: 113 ICNTGYSLQ 121
>NP_001726
          Length = 1676

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISNTGVSI 8
           ISNTG+ +
Sbjct: 804 ISNTGICV 811
>NP_001129477
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISNTGVSI 8
          ISNT +SI
Sbjct: 45 ISNTAISI 52
>NP_001129478
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISNTGVSI 8
          ISNT +SI
Sbjct: 45 ISNTAISI 52
>NP_055495
          Length = 2235

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISNTGVSIQ 9
           ISN  +SIQ
Sbjct: 425 ISNVNISIQ 433
>NP_000810
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISNTGVSI 8
          ISNT +SI
Sbjct: 45 ISNTAISI 52
>XP_006724053
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISNTGVSI 8
          ISNT +SI
Sbjct: 45 ISNTAISI 52
>XP_006724052
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISNTGVSI 8
          ISNT +SI
Sbjct: 45 ISNTAISI 52
>XP_005260998
          Length = 1010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISNTGVSI 8
          ISNT +SI
Sbjct: 45 ISNTAISI 52
>XP_006724051
          Length = 1026

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISNTGVSI 8
          ISNT +SI
Sbjct: 61 ISNTAISI 68
>XP_006722261
          Length = 2092

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISNTGVSIQ 9
           ISN  +SIQ
Sbjct: 282 ISNVNISIQ 290
>XP_005258130
          Length = 2234

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISNTGVSIQ 9
           ISN  +SIQ
Sbjct: 425 ISNVNISIQ 433
>NP_780294
          Length = 433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ISNTGVSI 8
          ISNT +SI
Sbjct: 45 ISNTAISI 52
>NP_001231892
          Length = 2488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SNTGVSIQ 9
           S+TGVS++
Sbjct: 715 SSTGVSVE 722
>NP_001104488
          Length = 2365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SNTGVSIQ 9
           S+TGVS++
Sbjct: 628 SSTGVSVE 635
>NP_689760
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISNTGVSIQ 9
           +SN  VSIQ
Sbjct: 222 LSNVSVSIQ 230
>NP_660093
          Length = 2429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SNTGVSIQ 9
           S+TGVS++
Sbjct: 692 SSTGVSVE 699
>NP_065831
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    NTGVSI 8
            NTGVSI
Sbjct: 1325 NTGVSI 1330
>NP_892009
          Length = 2432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SNTGVSIQ 9
           S+TGVS++
Sbjct: 692 SSTGVSVE 699
>NP_001171019
          Length = 389

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ISNTGV 6
           ISNTGV
Sbjct: 309 ISNTGV 314
>NP_001171020
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ISNTGV 6
           ISNTGV
Sbjct: 287 ISNTGV 292
>NP_001236
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ISNTGV 6
           ISNTGV
Sbjct: 298 ISNTGV 303
>NP_942143
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ISNTGV 6
           ISNTGV
Sbjct: 298 ISNTGV 303
>NP_001171018
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ISNTGV 6
           ISNTGV
Sbjct: 246 ISNTGV 251
>NP_942142
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   ISNTGV 6
           ISNTGV
Sbjct: 282 ISNTGV 287
>XP_006718429
          Length = 2416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SNTGVSIQ 9
           S+TGVS++
Sbjct: 643 SSTGVSVE 650
>XP_006718428
          Length = 2455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SNTGVSIQ 9
           S+TGVS++
Sbjct: 715 SSTGVSVE 722
>XP_006718427
          Length = 2465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SNTGVSIQ 9
           S+TGVS++
Sbjct: 692 SSTGVSVE 699
>XP_005265881
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISNTGVSIQ 9
           +SN  VSIQ
Sbjct: 222 LSNVSVSIQ 230
>XP_006714888
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISNTGVSIQ 9
           +SN  VSIQ
Sbjct: 153 LSNVSVSIQ 161
>XP_006714887
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISNTGVSIQ 9
           +SN  VSIQ
Sbjct: 222 LSNVSVSIQ 230
>XP_006714886
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISNTGVSIQ 9
           +SN  VSIQ
Sbjct: 222 LSNVSVSIQ 230
>NP_004855
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SNTGVSIQ 9
           ++TGVS+Q
Sbjct: 288 TDTGVSLQ 295
>NP_003821
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ISNTGV 6
           ISNTG+
Sbjct: 293 ISNTGI 298
>NP_001274745
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 977 NTGVSV 982
>NP_055662
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 966 NTGVSV 971
>NP_002536
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 231 NTGVSV 236
>NP_001012393
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 224 NTGVSV 229
>NP_852111
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ISNTGV 6
           ISNTG+
Sbjct: 127 ISNTGI 132
>NP_000136
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ISNTGV 6
           ISNTG+
Sbjct: 127 ISNTGI 132
>NP_775871
          Length = 8384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    ISNTGVS 7
            +SNTG++
Sbjct: 6224 VSNTGIT 6230
>NP_005796
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SNTGVSIQ 9
          S TGVS++
Sbjct: 78 SGTGVSVE 85
>XP_006723231
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ISNTGVSI 8
           +SNTG+ +
Sbjct: 347 LSNTGIGL 354
>XP_005258877
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ISNTGVSI 8
           +SNTG+ +
Sbjct: 347 LSNTGIGL 354
>XP_005258876
          Length = 818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ISNTGVSI 8
           +SNTG+ +
Sbjct: 429 LSNTGIGL 436
>XP_005253680
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ISNTGVSIQ 9
           I+NTG+  Q
Sbjct: 363 ITNTGIMTQ 371
>XP_005271636
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  NTGVSI 8
          NTGVS+
Sbjct: 93 NTGVSV 98
>XP_005271635
          Length = 245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 131 NTGVSV 136
>XP_005271632
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 231 NTGVSV 236
>XP_006718909
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 223 NTGVSV 228
>XP_005271631
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 230 NTGVSV 235
>XP_006711752
          Length = 1085

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 966 NTGVSV 971
>XP_006711751
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 626 NTGVSV 631
>XP_006711750
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 736 NTGVSV 741
>XP_006711749
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 771 NTGVSV 776
>XP_005245729
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 966 NTGVSV 971
>XP_005245727
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_005245726
          Length = 1095

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_005245725
          Length = 1096

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_005245724
          Length = 1098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_005245715
          Length = 1115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_006711748
          Length = 1160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 966 NTGVSV 971
>XP_006711747
          Length = 1160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 966 NTGVSV 971
>XP_006711746
          Length = 1160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 966 NTGVSV 971
>XP_006711745
          Length = 1170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_006711744
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_006711743
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 977 NTGVSV 982
>XP_006711742
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTGVSI 8
           NTGVS+
Sbjct: 977 NTGVSV 982
>NP_054756
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ISNTGVSI 8
           +SNTG+ +
Sbjct: 347 LSNTGIGL 354
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.122    0.296 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 499,092
Number of extensions: 659
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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