Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           18    1482
NP_000170                                                              18    1482
NP_001268422                                                           18    1482
NP_001268423                                                           18    1482
XP_005264328                                                           18    1482
NP_110393                                                              17    2528
NP_620048                                                              17    2528
NP_620049                                                              17    2528
XP_006719214                                                           17    2528
NP_001128248                                                           17    3301
NP_001128247                                                           17    3301
NP_001128246                                                           17    3301
XP_006718728                                                           17    3301
XP_005274241                                                           17    3301
XP_005274240                                                           17    3301
XP_005274239                                                           17    3301
NP_073733                                                              17    3301
NP_001276005                                                           16    5631
NP_001276008                                                           16    5631
NP_001029030                                                           16    5631
NP_071932                                                              16    5631
NP_001276006                                                           16    5631
NP_001029029                                                           16    5631
NP_001029027                                                           16    5631
NP_001276007                                                           16    5631
XP_005252615                                                           16    5631
XP_006717554                                                           16    5631
NP_036546                                                              16    7355
NP_940908                                                              16    7355
XP_006720393                                                           16    7355
XP_006720392                                                           16    7355
XP_006720391                                                           16    7355
XP_005263036                                                           16    7355
NP_005302                                                              15    9605
NP_001001549                                                           15    9605
NP_001001550                                                           15    9605
NP_001001555                                                           15    9605
NP_443137                                                              15    9605
NP_001010903                                                           15    9605
NP_001264090                                                           15    9605
NP_689804                                                              15    9605
NP_660356                                                              15    9605
NP_612373                                                              15    9605
NP_001273173                                                           15    9605
NP_775899                                                              15    9605
NP_004736                                                              15    9605
NP_001273172                                                           15    9605
NP_001269791                                                           15    9605
XP_006719326                                                           15    9605
XP_006719325                                                           15    9605
XP_005271866                                                           15    9605
XP_005271865                                                           15    9605
XP_005266095                                                           15    9605
XP_006715768                                                           15    9605
XP_005271823                                                           15    9605
XP_005271822                                                           15    9605
XP_006715767                                                           15    9605
XP_006715766                                                           15    9605
XP_005271818                                                           15    9605
XP_005271817                                                           15    9605
XP_005263397                                                           15    9605
XP_005263396                                                           15    9605
XP_005263395                                                           15    9605
XP_006712292                                                           15    9605
XP_005246323                                                           15    9605
XP_005246322                                                           15    9605
XP_006712291                                                           15    9605
XP_005246320                                                           15    9605
NP_060422                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISKVVELLK 9
           IS+VVELLK
Sbjct: 675 ISEVVELLK 683
>NP_000170
          Length = 1360

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISKVVELLK 9
           IS+VVELLK
Sbjct: 805 ISEVVELLK 813
>NP_001268422
          Length = 1058

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISKVVELLK 9
           IS+VVELLK
Sbjct: 503 ISEVVELLK 511
>NP_001268423
          Length = 1058

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISKVVELLK 9
           IS+VVELLK
Sbjct: 503 ISEVVELLK 511
>XP_005264328
          Length = 1261

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ISKVVELLK 9
           IS+VVELLK
Sbjct: 706 ISEVVELLK 714
>NP_110393
          Length = 252

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ISKVVELLK 9
           ++K+VELLK
Sbjct: 209 LAKIVELLK 217
>NP_620048
          Length = 327

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ISKVVELLK 9
           ++K+VELLK
Sbjct: 209 LAKIVELLK 217
>NP_620049
          Length = 327

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ISKVVELLK 9
           ++K+VELLK
Sbjct: 209 LAKIVELLK 217
>XP_006719214
          Length = 327

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ISKVVELLK 9
           ++K+VELLK
Sbjct: 209 LAKIVELLK 217
>NP_001128248
          Length = 622

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +KVVELLK
Sbjct: 489 TKVVELLK 496
>NP_001128247
          Length = 622

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +KVVELLK
Sbjct: 489 TKVVELLK 496
>NP_001128246
          Length = 545

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +KVVELLK
Sbjct: 412 TKVVELLK 419
>XP_006718728
          Length = 599

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +KVVELLK
Sbjct: 489 TKVVELLK 496
>XP_005274241
          Length = 600

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +KVVELLK
Sbjct: 489 TKVVELLK 496
>XP_005274240
          Length = 622

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +KVVELLK
Sbjct: 489 TKVVELLK 496
>XP_005274239
          Length = 622

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +KVVELLK
Sbjct: 489 TKVVELLK 496
>NP_073733
          Length = 622

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +KVVELLK
Sbjct: 489 TKVVELLK 496
>NP_001276005
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           + KVVE+LK
Sbjct: 233 MDKVVEILK 241
>NP_001276008
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           + KVVE+LK
Sbjct: 228 MDKVVEILK 236
>NP_001029030
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           + KVVE+LK
Sbjct: 228 MDKVVEILK 236
>NP_071932
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           + KVVE+LK
Sbjct: 233 MDKVVEILK 241
>NP_001276006
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           + KVVE+LK
Sbjct: 228 MDKVVEILK 236
>NP_001029029
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           + KVVE+LK
Sbjct: 228 MDKVVEILK 236
>NP_001029027
          Length = 692

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           + KVVE+LK
Sbjct: 348 MDKVVEILK 356
>NP_001276007
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           + KVVE+LK
Sbjct: 233 MDKVVEILK 241
>XP_005252615
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           + KVVE+LK
Sbjct: 228 MDKVVEILK 236
>XP_006717554
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           + KVVE+LK
Sbjct: 233 MDKVVEILK 241
>NP_036546
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    ISKVVELL 8
            ++KV+ELL
Sbjct: 1361 VNKVIELL 1368
>NP_940908
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           ISK++EL K
Sbjct: 209 ISKMIELSK 217
>XP_006720393
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISKVVEL 7
           +SKVVEL
Sbjct: 458 VSKVVEL 464
>XP_006720392
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISKVVEL 7
           +SKVVEL
Sbjct: 458 VSKVVEL 464
>XP_006720391
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   ISKVVEL 7
           +SKVVEL
Sbjct: 458 VSKVVEL 464
>XP_005263036
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ISKVVELLK 9
          ISK++EL K
Sbjct: 26 ISKMIELSK 34
>NP_005302
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 179 SKVVEIL 185
>NP_001001549
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 179 SKVVEIL 185
>NP_001001550
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 121 SKVVEIL 127
>NP_001001555
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 121 SKVVEIL 127
>NP_443137
          Length = 1092

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK+VEL K
Sbjct: 417 MSKIVELEK 425
>NP_001010903
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKVVELLK 9
           I  +VELLK
Sbjct: 247 IQMIVELLK 255
>NP_001264090
          Length = 961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKVVELLK 9
           +SK  ELLK
Sbjct: 623 VSKAEELLK 631
>NP_689804
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK ++LLK
Sbjct: 403 VSKTLDLLK 411
>NP_660356
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +K+V+LLK
Sbjct: 115 AKIVQLLK 122
>NP_612373
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK VELL+
Sbjct: 750 LSKPVELLR 758
>NP_001273173
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK ++LLK
Sbjct: 324 VSKTLDLLK 332
>NP_775899
          Length = 4462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   ISKVVELLK 9
           ++K+VE+L+
Sbjct: 250 VNKIVEILE 258
>NP_004736
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKVVELLK 9
           +SK  ELLK
Sbjct: 623 VSKAEELLK 631
>NP_001273172
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK ++LLK
Sbjct: 363 VSKTLDLLK 371
>NP_001269791
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +K+V+LLK
Sbjct: 123 AKIVQLLK 130
>XP_006719326
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK ++LLK
Sbjct: 403 VSKTLDLLK 411
>XP_006719325
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK ++LLK
Sbjct: 403 VSKTLDLLK 411
>XP_005271866
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SKVVELLK 9
          +K+V+LLK
Sbjct: 35 AKIVQLLK 42
>XP_005271865
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           +K+V+LLK
Sbjct: 115 AKIVQLLK 122
>XP_005266095
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKVVELLK 9
           +SK  ELLK
Sbjct: 726 VSKAEELLK 734
>XP_006715768
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 121 SKVVEIL 127
>XP_005271823
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 121 SKVVEIL 127
>XP_005271822
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 121 SKVVEIL 127
>XP_006715767
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 173 SKVVEIL 179
>XP_006715766
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 179 SKVVEIL 185
>XP_005271818
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 179 SKVVEIL 185
>XP_005271817
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SKVVELL 8
           SKVVE+L
Sbjct: 179 SKVVEIL 185
>XP_005263397
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK VELL+
Sbjct: 445 LSKPVELLR 453
>XP_005263396
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK VELL+
Sbjct: 637 LSKPVELLR 645
>XP_005263395
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK VELL+
Sbjct: 671 LSKPVELLR 679
>XP_006712292
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK+VEL K
Sbjct: 417 MSKIVELEK 425
>XP_005246323
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK+VEL K
Sbjct: 417 MSKIVELEK 425
>XP_005246322
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK+VEL K
Sbjct: 417 MSKIVELEK 425
>XP_006712291
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK+VEL K
Sbjct: 417 MSKIVELEK 425
>XP_005246320
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISKVVELLK 9
           +SK+VEL K
Sbjct: 417 MSKIVELEK 425
>NP_060422
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SKVVELLK 9
           SK++ELL+
Sbjct: 314 SKILELLR 321
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.138    0.308 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 302,085
Number of extensions: 501
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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