Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              20     390
NP_001035957                                                           20     390
XP_006721991                                                           20     390
XP_006721990                                                           20     390
XP_006721989                                                           20     390
XP_005258041                                                           20     390
XP_006721988                                                           20     390
XP_006721987                                                           20     390
XP_006721986                                                           20     390
XP_005258040                                                           20     390
XP_006721985                                                           20     390
NP_001153239                                                           18    1935
NP_054757                                                              18    1935
XP_006715771                                                           18    1935
XP_006715770                                                           18    1935
XP_006715769                                                           18    1935
NP_689472                                                              17    3301
NP_001193997                                                           17    3301
NP_055485                                                              17    3301
NP_001193998                                                           17    3301
NP_001193996                                                           17    3301
NP_001277114                                                           16    5631
NP_001231639                                                           16    5631
NP_002047                                                              16    5631
NP_068375                                                              16    5631
NP_001263407                                                           16    5631
NP_004959                                                              16    5631
NP_001129492                                                           16    5631
NP_071682                                                              16    5631
NP_898898                                                              16    5631
NP_778238                                                              16    5631
XP_006715783                                                           16    5631
XP_005249793                                                           16    5631
XP_005249792                                                           16    5631
XP_006715782                                                           16    5631
XP_006715781                                                           16    5631
XP_006715780                                                           16    5631
XP_005262777                                                           16    5631
XP_005262774                                                           16    5631
NP_006840                                                              16    5631
NP_004084                                                              16    7355
NP_001034                                                              16    7355
NP_002431                                                              16    7355
NP_002106                                                              16    7355
NP_001165972                                                           16    7355
NP_001165973                                                           16    7355
NP_056052                                                              16    7355
NP_005101                                                              16    7355
NP_001074003                                                           16    7355
NP_001165975                                                           16    7355
XP_006721326                                                           16    7355
XP_005254452                                                           16    7355
XP_005254451                                                           16    7355
XP_006715005                                                           16    7355
NP_777557                                                              16    7355
NP_001020332                                                           15    9605
NP_000097                                                              15    9605
NP_000431                                                              15    9605
NP_006436                                                              15    9605
NP_001860                                                              15    9605
NP_997077                                                              15    9605
NP_001269360                                                           15    9605
XP_006726383                                                           15    9605
XP_005278414                                                           15    9605
XP_006726380                                                           15    9605
XP_005278411                                                           15    9605
XP_006724220                                                           15    9605
XP_005269367                                                           15    9605
NP_689912                                                              15    9605
NP_001812                                                              15    9605
NP_005728                                                              15    9605
>NP_000258
          Length = 2818

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 941 ISKFFDSQG 949
>NP_001035957
          Length = 2839

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 941 ISKFFDSQG 949
>XP_006721991
          Length = 1632

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 951 ISKFFDSQG 959
>XP_006721990
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 951 ISKFFDSQG 959
>XP_006721989
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 951 ISKFFDSQG 959
>XP_005258041
          Length = 2836

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 941 ISKFFDSQG 949
>XP_006721988
          Length = 2846

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 951 ISKFFDSQG 959
>XP_006721987
          Length = 2849

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 951 ISKFFDSQG 959
>XP_006721986
          Length = 2854

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 938 ISKFFDSQG 946
>XP_005258040
          Length = 2857

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 941 ISKFFDSQG 949
>XP_006721985
          Length = 2867

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ISKF DSQG
Sbjct: 951 ISKFFDSQG 959
>NP_001153239
          Length = 419

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ISKFLDSQG 9
          ++KFLDS G
Sbjct: 48 VAKFLDSTG 56
>NP_054757
          Length = 419

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ISKFLDSQG 9
          ++KFLDS G
Sbjct: 48 VAKFLDSTG 56
>XP_006715771
          Length = 419

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ISKFLDSQG 9
          ++KFLDS G
Sbjct: 48 VAKFLDSTG 56
>XP_006715770
          Length = 419

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ISKFLDSQG 9
          ++KFLDS G
Sbjct: 48 VAKFLDSTG 56
>XP_006715769
          Length = 419

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ISKFLDSQG 9
          ++KFLDS G
Sbjct: 48 VAKFLDSTG 56
>NP_689472
          Length = 1910

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KFLDSQG 9
          KF DSQG
Sbjct: 48 KFFDSQG 54
>NP_001193997
          Length = 451

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ISKFLDSQG 9
          ++KFLD+ G
Sbjct: 82 VAKFLDASG 90
>NP_055485
          Length = 353

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ISKFLDSQG 9
          ++KFLD+ G
Sbjct: 50 VAKFLDASG 58
>NP_001193998
          Length = 423

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ISKFLDSQG 9
          ++KFLD+ G
Sbjct: 54 VAKFLDASG 62
>NP_001193996
          Length = 419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ISKFLDSQG 9
          ++KFLD+ G
Sbjct: 50 VAKFLDASG 58
>NP_001277114
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ISKFLDSQ 8
           I KFLD+Q
Sbjct: 414 IRKFLDAQ 421
>NP_001231639
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           + KFL+S+G
Sbjct: 132 LKKFLESKG 140
>NP_002047
          Length = 681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           + KFL+S+G
Sbjct: 132 LKKFLESKG 140
>NP_068375
          Length = 941

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ISKFLDSQ 8
           I KFLD+Q
Sbjct: 424 IRKFLDAQ 431
>NP_001263407
          Length = 482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           + KFL SQG
Sbjct: 93  LGKFLRSQG 101
>NP_004959
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           + KFL SQG
Sbjct: 94  LGKFLRSQG 102
>NP_001129492
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           + KFL SQG
Sbjct: 94  LGKFLRSQG 102
>NP_071682
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           + KFL SQG
Sbjct: 94  LGKFLRSQG 102
>NP_898898
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SKFLDSQG 9
           ++FLD QG
Sbjct: 465 NRFLDDQG 472
>NP_778238
          Length = 540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SKFLDSQG 9
           S+F DSQG
Sbjct: 519 SEFRDSQG 526
>XP_006715783
          Length = 482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           + KFL SQG
Sbjct: 93  LGKFLRSQG 101
>XP_005249793
          Length = 482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           + KFL SQG
Sbjct: 93  LGKFLRSQG 101
>XP_005249792
          Length = 482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           + KFL SQG
Sbjct: 93  LGKFLRSQG 101
>XP_006715782
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           + KFL SQG
Sbjct: 94  LGKFLRSQG 102
>XP_006715781
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           + KFL SQG
Sbjct: 94  LGKFLRSQG 102
>XP_006715780
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           + KFL SQG
Sbjct: 94  LGKFLRSQG 102
>XP_005262777
          Length = 332

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SKFLDSQG 9
           ++FLD QG
Sbjct: 253 NRFLDDQG 260
>XP_005262774
          Length = 562

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SKFLDSQG 9
           ++FLD QG
Sbjct: 483 NRFLDDQG 490
>NP_006840
          Length = 525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SKFLDSQG 9
           SKFLD+ G
Sbjct: 488 SKFLDNGG 495
>NP_004084
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  SKFLDSQG 9
          SKFL  QG
Sbjct: 40 SKFLPGQG 47
>NP_001034
          Length = 617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           I KFL +QG
Sbjct: 574 IYKFLSTQG 582
>NP_002431
          Length = 936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ISKFLDSQ 8
           IS+FLD++
Sbjct: 389 ISRFLDTE 396
>NP_002106
          Length = 923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ISKFLDSQ 8
           +S+FLD+Q
Sbjct: 147 LSEFLDAQ 154
>NP_001165972
          Length = 617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           I KFL +QG
Sbjct: 574 IYKFLSTQG 582
>NP_001165973
          Length = 512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           I KFL +QG
Sbjct: 469 IYKFLSTQG 477
>NP_056052
          Length = 1354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    SKFLDS 7
            SKFLDS
Sbjct: 1132 SKFLDS 1137
>NP_005101
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           + KFL+S+G
Sbjct: 129 LRKFLESKG 137
>NP_001074003
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ISKFLDSQ 8
            I KF+D+Q
Sbjct: 2025 IKKFIDTQ 2032
>NP_001165975
          Length = 628

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           I KFL +QG
Sbjct: 574 IYKFLSTQG 582
>XP_006721326
          Length = 628

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           I KFL +QG
Sbjct: 574 IYKFLSTQG 582
>XP_005254452
          Length = 2188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ISKFLDSQ 8
            I KF+D+Q
Sbjct: 1999 IKKFIDTQ 2006
>XP_005254451
          Length = 2214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ISKFLDSQ 8
            I KF+D+Q
Sbjct: 2025 IKKFIDTQ 2032
>XP_006715005
          Length = 628

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           + KFL+S+G
Sbjct: 129 LRKFLESKG 137
>NP_777557
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ISKFLDS 7
           ++KFLDS
Sbjct: 157 VNKFLDS 163
>NP_001020332
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FLDSQG 9
           FLD+QG
Sbjct: 369 FLDAQG 374
>NP_000097
          Length = 497

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FLDSQG 9
           FLD+QG
Sbjct: 420 FLDAQG 425
>NP_000431
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ISKFLDS 7
          + KFLDS
Sbjct: 9  VEKFLDS 15
>NP_006436
          Length = 2335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    SKFLDSQ 8
            S+F+DSQ
Sbjct: 1377 SEFIDSQ 1383
>NP_001860
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  ISKFLDSQG 9
          +  FL+SQG
Sbjct: 77 VKVFLESQG 85
>NP_997077
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           +SK L SQG
Sbjct: 779 VSKRLQSQG 787
>NP_001269360
          Length = 201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ++KF ++QG
Sbjct: 111 VTKFAENQG 119
>XP_006726383
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FLDSQG 9
           FLD+QG
Sbjct: 421 FLDAQG 426
>XP_005278414
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FLDSQG 9
           FLD+QG
Sbjct: 320 FLDAQG 325
>XP_006726380
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FLDSQG 9
           FLD+QG
Sbjct: 421 FLDAQG 426
>XP_005278411
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FLDSQG 9
           FLD+QG
Sbjct: 320 FLDAQG 325
>XP_006724220
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FLDSQG 9
           FLD+QG
Sbjct: 361 FLDAQG 366
>XP_005269367
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ISKFLDSQG 9
           I  F DSQG
Sbjct: 658 IISFYDSQG 666
>NP_689912
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ISKFLDSQG 9
           I  F DSQG
Sbjct: 658 IISFYDSQG 666
>NP_001812
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ISKFLDSQG 9
           +SK L SQG
Sbjct: 234 VSKLLYSQG 242
>NP_005728
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISKFLDSQG 9
           ++KF ++QG
Sbjct: 111 VTKFAENQG 119
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.136    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 507,045
Number of extensions: 1119
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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