Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           18    1935
NP_858045                                                              18    1935
NP_006525                                                              18    1935
NP_001167559                                                           18    1935
NP_065961                                                              17    2528
NP_001158137                                                           17    2528
XP_006716134                                                           17    2528
XP_005245269                                                           16    5631
XP_006711403                                                           16    5631
NP_653300                                                              16    5631
NP_055561                                                              16    7355
NP_001019554                                                           16    7355
NP_064620                                                              16    7355
NP_001136040                                                           16    7355
NP_055160                                                              16    7355
NP_055718                                                              16    7355
XP_006719739                                                           16    7355
XP_006719738                                                           16    7355
XP_005269272                                                           16    7355
XP_006713772                                                           16    7355
XP_006713771                                                           16    7355
XP_005247703                                                           16    7355
XP_006713770                                                           16    7355
XP_006713769                                                           16    7355
XP_005247702                                                           16    7355
XP_005247701                                                           16    7355
XP_005247700                                                           16    7355
XP_005247699                                                           16    7355
XP_005246260                                                           16    7355
XP_005246259                                                           16    7355
XP_005246258                                                           16    7355
XP_005246257                                                           16    7355
XP_006711972                                                           16    7355
NP_002151                                                              15    9605
NP_444256                                                              15    9605
NP_444254                                                              15    9605
NP_444253                                                              15    9605
NP_444255                                                              15    9605
NP_055437                                                              15    9605
NP_001164277                                                           15    9605
NP_075559                                                              15    9605
NP_775820                                                              15    9605
XP_005252032                                                           15    9605
XP_006717164                                                           15    9605
XP_005252031                                                           15    9605
XP_005252030                                                           15    9605
XP_006717163                                                           15    9605
XP_006717162                                                           15    9605
XP_006717161                                                           15    9605
XP_006717160                                                           15    9605
XP_005252029                                                           15    9605
XP_006717159                                                           15    9605
XP_005247551                                                           15    9605
XP_005247550                                                           15    9605
XP_006713712                                                           15    9605
XP_005247549                                                           15    9605
NP_001123614                                                           15    9605
>NP_001167558
          Length = 1423

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           ISEGV TSL
Sbjct: 529 ISEGVGTSL 537
>NP_858045
          Length = 1424

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           ISEGV TSL
Sbjct: 529 ISEGVGTSL 537
>NP_006525
          Length = 1420

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           ISEGV TSL
Sbjct: 529 ISEGVGTSL 537
>NP_001167559
          Length = 1415

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           ISEGV TSL
Sbjct: 539 ISEGVGTSL 547
>NP_065961
          Length = 1934

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ISEGVETSL 9
           ++EGVET+L
Sbjct: 273 LTEGVETTL 281
>NP_001158137
          Length = 1950

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ISEGVETSL 9
           ++EGVET+L
Sbjct: 273 LTEGVETTL 281
>XP_006716134
          Length = 1847

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ISEGVETSL 9
           ++EGVET+L
Sbjct: 197 LTEGVETTL 205
>XP_005245269
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ISEGVETS 8
           ISEG ET+
Sbjct: 143 ISEGTETA 150
>XP_006711403
          Length = 961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ISEGVETS 8
           ISEG ET+
Sbjct: 572 ISEGTETA 579
>NP_653300
          Length = 1029

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   ISEGVETS 8
           ISEG ET+
Sbjct: 640 ISEGTETA 647
>NP_055561
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ISEGVETSL 9
          I EG+ET++
Sbjct: 55 IKEGLETAI 63
>NP_001019554
          Length = 2385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ISEGVETS 8
           +SEGV+T+
Sbjct: 370 VSEGVKTA 377
>NP_064620
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>NP_001136040
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>NP_055160
          Length = 2279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            + EGV TS+
Sbjct: 1793 VDEGVSTSI 1801
>NP_055718
          Length = 2363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ISEGVETS 8
           +SEGV+T+
Sbjct: 370 VSEGVKTA 377
>XP_006719739
          Length = 2306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ISEGVETS 8
           +SEGV+T+
Sbjct: 313 VSEGVKTA 320
>XP_006719738
          Length = 2340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ISEGVETS 8
           +SEGV+T+
Sbjct: 347 VSEGVKTA 354
>XP_005269272
          Length = 2356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ISEGVETS 8
           +SEGV+T+
Sbjct: 370 VSEGVKTA 377
>XP_006713772
          Length = 885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>XP_006713771
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>XP_005247703
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>XP_006713770
          Length = 915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>XP_006713769
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>XP_005247702
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>XP_005247701
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>XP_005247700
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>XP_005247699
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ISEGVETSL 9
           +SEG+ TSL
Sbjct: 624 VSEGMLTSL 632
>XP_005246260
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ISEGVETSL 9
          I EG+ET++
Sbjct: 55 IKEGLETAI 63
>XP_005246259
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ISEGVETSL 9
          I EG+ET++
Sbjct: 55 IKEGLETAI 63
>XP_005246258
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ISEGVETSL 9
          I EG+ET++
Sbjct: 55 IKEGLETAI 63
>XP_005246257
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ISEGVETSL 9
          I EG+ET++
Sbjct: 55 IKEGLETAI 63
>XP_006711972
          Length = 300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ISEGVETSL 9
          I EG+ET++
Sbjct: 63 IKEGLETAI 71
>NP_002151
          Length = 2201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>NP_444256
          Length = 1794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ISEGVE 6
            ISEGVE
Sbjct: 1500 ISEGVE 1505
>NP_444254
          Length = 1845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ISEGVE 6
            ISEGVE
Sbjct: 1500 ISEGVE 1505
>NP_444253
          Length = 1914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ISEGVE 6
            ISEGVE
Sbjct: 1569 ISEGVE 1574
>NP_444255
          Length = 1863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ISEGVE 6
            ISEGVE
Sbjct: 1569 ISEGVE 1574
>NP_055437
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ISEGVETSL 9
           I EG  TSL
Sbjct: 421 IGEGTSTSL 429
>NP_001164277
          Length = 56

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ISEGVET 7
          +SEG ET
Sbjct: 35 VSEGAET 41
>NP_075559
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ISEGVET 7
           +SEG+ET
Sbjct: 147 LSEGLET 153
>NP_775820
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ISEGVET 7
           +SEG ET
Sbjct: 353 VSEGAET 359
>XP_005252032
          Length = 1564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>XP_006717164
          Length = 1655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>XP_005252031
          Length = 1655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>XP_005252030
          Length = 1837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>XP_006717163
          Length = 1928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>XP_006717162
          Length = 1928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>XP_006717161
          Length = 2019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>XP_006717160
          Length = 2110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>XP_005252029
          Length = 2110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>XP_006717159
          Length = 2293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ISEGVETSL 9
            +SE  ETSL
Sbjct: 993  VSETAETSL 1001
>XP_005247551
          Length = 1855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ISEGVE 6
            ISEGVE
Sbjct: 1510 ISEGVE 1515
>XP_005247550
          Length = 1856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ISEGVE 6
            ISEGVE
Sbjct: 1511 ISEGVE 1516
>XP_006713712
          Length = 1923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ISEGVE 6
            ISEGVE
Sbjct: 1579 ISEGVE 1584
>XP_005247549
          Length = 1924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    ISEGVE 6
            ISEGVE
Sbjct: 1579 ISEGVE 1584
>NP_001123614
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   ISEGVETSL 9
           I EG  TSL
Sbjct: 421 IGEGTSTSL 429
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.120    0.276 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 525,629
Number of extensions: 982
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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