Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              18    1482
NP_733762                                                              18    1482
XP_006713860                                                           18    1482
XP_006713859                                                           18    1482
XP_005247910                                                           18    1482
XP_005247909                                                           18    1482
NP_001243694                                                           17    2528
XP_006717509                                                           17    2528
NP_066288                                                              17    3301
NP_000535                                                              17    4312
NP_061313                                                              17    4312
NP_006035                                                              17    4312
NP_001276972                                                           17    4312
XP_005272625                                                           17    4312
XP_006724588                                                           17    4312
XP_005272623                                                           17    4312
XP_005272622                                                           17    4312
XP_005272621                                                           17    4312
NP_001129673                                                           16    5631
NP_078986                                                              16    5631
NP_001598                                                              16    5631
NP_001014364                                                           16    5631
NP_775922                                                              16    5631
XP_006724409                                                           16    5631
XP_005261851                                                           16    5631
XP_005261850                                                           16    5631
XP_006713185                                                           16    5631
NP_001138678                                                           16    5631
NP_001274679                                                           16    7355
NP_001229263                                                           16    7355
NP_055183                                                              16    7355
NP_954629                                                              16    7355
NP_001229262                                                           16    7355
XP_005251973                                                           16    7355
XP_005251972                                                           16    7355
NP_056099                                                              15    9605
NP_057726                                                              15    9605
NP_055558                                                              15    9605
NP_001094060                                                           15    9605
NP_001255213                                                           15    9605
NP_006284                                                              15    9605
NP_848627                                                              15    9605
NP_055892                                                              15    9605
NP_001107033                                                           15    9605
NP_079357                                                              15    9605
NP_872433                                                              15    9605
NP_079337                                                              15    9605
XP_005272554                                                           15    9605
XP_005254495                                                           15    9605
XP_005254968                                                           15    9605
XP_005254967                                                           15    9605
XP_006720570                                                           15    9605
XP_005268536                                                           15    9605
XP_006714654                                                           15    9605
XP_006714653                                                           15    9605
XP_006714652                                                           15    9605
XP_006713998                                                           15    9605
XP_006713997                                                           15    9605
XP_005269377                                                           15    9605
XP_005269376                                                           15    9605
XP_005245669                                                           15    9605
XP_006710565                                                           15    9605
XP_006710564                                                           15    9605
XP_005270743                                                           15    9605
NP_006113                                                              15    9605
NP_612400                                                              15    9605
NP_001073277                                                           15    9605
NP_598005                                                              15    9605
NP_001255214                                                           15    9605
>NP_005179
          Length = 906

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISCGLEAMA 9
           IS GLEAMA
Sbjct: 215 ISSGLEAMA 223
>NP_733762
          Length = 982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISCGLEAMA 9
           IS GLEAMA
Sbjct: 207 ISSGLEAMA 215
>XP_006713860
          Length = 914

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISCGLEAMA 9
           IS GLEAMA
Sbjct: 235 ISSGLEAMA 243
>XP_006713859
          Length = 966

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISCGLEAMA 9
           IS GLEAMA
Sbjct: 235 ISSGLEAMA 243
>XP_005247910
          Length = 982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISCGLEAMA 9
           IS GLEAMA
Sbjct: 207 ISSGLEAMA 215
>XP_005247909
          Length = 1010

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISCGLEAMA 9
           IS GLEAMA
Sbjct: 235 ISSGLEAMA 243
>NP_001243694
          Length = 353

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ISCGLEAMA 9
          +SCG  AMA
Sbjct: 29 VSCGAAAMA 37
>XP_006717509
          Length = 237

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  ISCGLEAMA 9
          +SCG  AMA
Sbjct: 29 VSCGAAAMA 37
>NP_066288
          Length = 565

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ISCGLEAMA 9
           ++CG EAM+
Sbjct: 505 VNCGREAMS 513
>NP_000535
          Length = 703

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISCGLEAM 8
           +SCGL+ M
Sbjct: 392 LSCGLQQM 399
>NP_061313
          Length = 653

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISCGLEAM 8
           +SCGL+ M
Sbjct: 392 LSCGLQQM 399
>NP_006035
          Length = 1215

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISCGLEAM 8
           +SC LEA+
Sbjct: 424 VSCALEAL 431
>NP_001276972
          Length = 686

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISCGLEAM 8
           +SCGL+ M
Sbjct: 392 LSCGLQQM 399
>XP_005272625
          Length = 1215

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISCGLEAM 8
           +SC LEA+
Sbjct: 424 VSCALEAL 431
>XP_006724588
          Length = 1215

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISCGLEAM 8
           +SC LEA+
Sbjct: 424 VSCALEAL 431
>XP_005272623
          Length = 1215

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISCGLEAM 8
           +SC LEA+
Sbjct: 424 VSCALEAL 431
>XP_005272622
          Length = 1215

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISCGLEAM 8
           +SC LEA+
Sbjct: 424 VSCALEAL 431
>XP_005272621
          Length = 1261

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISCGLEAM 8
           +SC LEA+
Sbjct: 470 VSCALEAL 477
>NP_001129673
          Length = 205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CGLEAMA 9
           CG+EA A
Sbjct: 107 CGIEAQA 113
>NP_078986
          Length = 221

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CGLEAMA 9
           CG+EA A
Sbjct: 107 CGIEAQA 113
>NP_001598
          Length = 424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   ISCGLEAMA 9
           ++CG+E+M+
Sbjct: 146 MACGVESMS 154
>NP_001014364
          Length = 2391

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   ISCGLE 6
           +SCGLE
Sbjct: 240 LSCGLE 245
>NP_775922
          Length = 6996

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    SCGLEAMA 9
            SCGL+A++
Sbjct: 1595 SCGLKAIS 1602
>XP_006724409
          Length = 1806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ISCGLEAMA 9
           + CGLE  A
Sbjct: 782 LECGLEGQA 790
>XP_005261851
          Length = 1806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ISCGLEAMA 9
           + CGLE  A
Sbjct: 782 LECGLEGQA 790
>XP_005261850
          Length = 1806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ISCGLEAMA 9
           + CGLE  A
Sbjct: 782 LECGLEGQA 790
>XP_006713185
          Length = 364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   ISCGLEAMA 9
           ++CG+E+M+
Sbjct: 146 MACGVESMS 154
>NP_001138678
          Length = 1806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ISCGLEAMA 9
           + CGLE  A
Sbjct: 782 LECGLEGQA 790
>NP_001274679
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SCGLEAMA 9
          +CG +AMA
Sbjct: 5  ACGTKAMA 12
>NP_001229263
          Length = 363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SCGLEAM 8
          SCGLE +
Sbjct: 72 SCGLEIL 78
>NP_055183
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SCGLEAM 8
           SCGLE +
Sbjct: 101 SCGLEIL 107
>NP_954629
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SCGLEAM 8
           SCGLE +
Sbjct: 101 SCGLEIL 107
>NP_001229262
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SCGLEAM 8
          SCGLE +
Sbjct: 90 SCGLEIL 96
>XP_005251973
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SCGLEAM 8
           SCGLE +
Sbjct: 101 SCGLEIL 107
>XP_005251972
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SCGLEAM 8
          SCGLE +
Sbjct: 77 SCGLEIL 83
>NP_056099
          Length = 3375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    SCGLEAM 8
            SC LEA+
Sbjct: 1186 SCSLEAL 1192
>NP_057726
          Length = 3674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3    CGLEA 7
            CGLEA
Sbjct: 1869 CGLEA 1873
>NP_055558
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  CGLEAM 8
          CG++AM
Sbjct: 50 CGIDAM 55
>NP_001094060
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  CGLEAM 8
          CG++AM
Sbjct: 50 CGIDAM 55
>NP_001255213
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ISCGLE 6
           ++CGLE
Sbjct: 590 VACGLE 595
>NP_006284
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISCGLEAMA 9
           I+CG+E ++
Sbjct: 639 IACGMEYLS 647
>NP_848627
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   CGLEA 7
           CGLEA
Sbjct: 312 CGLEA 316
>NP_055892
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ISCGLE 6
           +SCGL+
Sbjct: 506 VSCGLD 511
>NP_001107033
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   CGLEA 7
           CGLEA
Sbjct: 312 CGLEA 316
>NP_079357
          Length = 1898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    ISCGLE 6
            ++CGLE
Sbjct: 1358 VACGLE 1363
>NP_872433
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ISCGLE 6
           +SCGL+
Sbjct: 153 VSCGLD 158
>NP_079337
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ISCGLE 6
           ++CGLE
Sbjct: 590 VACGLE 595
>XP_005272554
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ISCGLE 6
           ++CGLE
Sbjct: 590 VACGLE 595
>XP_005254495
          Length = 3694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3    CGLEA 7
            CGLEA
Sbjct: 1889 CGLEA 1893
>XP_005254968
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3    CGLEA 7
            CGLEA
Sbjct: 1089 CGLEA 1093
>XP_005254967
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3    CGLEA 7
            CGLEA
Sbjct: 1108 CGLEA 1112
>XP_006720570
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3    CGLEA 7
            CGLEA
Sbjct: 1114 CGLEA 1118
>XP_005268536
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  SCGLE 6
          SCGLE
Sbjct: 45 SCGLE 49
>XP_006714654
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   CGLEA 7
           CGLEA
Sbjct: 312 CGLEA 316
>XP_006714653
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   CGLEA 7
           CGLEA
Sbjct: 312 CGLEA 316
>XP_006714652
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   CGLEA 7
           CGLEA
Sbjct: 312 CGLEA 316
>XP_006713998
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  CGLEAM 8
          CG++AM
Sbjct: 50 CGIDAM 55
>XP_006713997
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3  CGLEAM 8
          CG++AM
Sbjct: 50 CGIDAM 55
>XP_005269377
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ISCGLE 6
           +SCGL+
Sbjct: 153 VSCGLD 158
>XP_005269376
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ISCGLE 6
           +SCGL+
Sbjct: 153 VSCGLD 158
>XP_005245669
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  CGLEA 7
          CGLEA
Sbjct: 71 CGLEA 75
>XP_006710565
          Length = 3140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SCGLEAM 8
           SC LEA+
Sbjct: 951 SCSLEAL 957
>XP_006710564
          Length = 3432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    SCGLEAM 8
            SC LEA+
Sbjct: 1243 SCSLEAL 1249
>XP_005270743
          Length = 3453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    SCGLEAM 8
            SC LEA+
Sbjct: 1264 SCSLEAL 1270
>NP_006113
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3    CGLEA 7
            CGLEA
Sbjct: 1083 CGLEA 1087
>NP_612400
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  CGLEA 7
          CGLEA
Sbjct: 71 CGLEA 75
>NP_001073277
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  CGLEA 7
          CGLEA
Sbjct: 71 CGLEA 75
>NP_598005
          Length = 124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  SCGLE 6
          SCGLE
Sbjct: 70 SCGLE 74
>NP_001255214
          Length = 667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ISCGLE 6
           ++CGLE
Sbjct: 461 VACGLE 466
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.131    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 609,963
Number of extensions: 516
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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