Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036462                                                              18    1482
NP_001243397                                                           18    1482
XP_005269721                                                           18    1482
NP_001007091                                                           17    3301
NP_000161                                                              17    4312
NP_689571                                                              16    5631
XP_006723071                                                           16    5631
NP_001127870                                                           16    7355
NP_003362                                                              16    7355
NP_061878                                                              16    7355
XP_005272270                                                           16    7355
XP_006717340                                                           16    7355
XP_005249840                                                           16    7355
XP_005249839                                                           16    7355
XP_005249838                                                           16    7355
XP_005249837                                                           16    7355
NP_060247                                                              15    9605
NP_001159399                                                           15    9605
NP_001073291                                                           15    9605
NP_000417                                                              15    9605
NP_620447                                                              15    9605
NP_620448                                                              15    9605
NP_620446                                                              15    9605
NP_002741                                                              15    9605
NP_001265477                                                           15    9605
NP_055575                                                              15    9605
NP_620637                                                              15    9605
NP_001265476                                                           15    9605
NP_620634                                                              15    9605
NP_002743                                                              15    9605
NP_001128516                                                           15    9605
NP_620709                                                              15    9605
NP_620707                                                              15    9605
NP_620708                                                              15    9605
NP_002744                                                              15    9605
NP_004183                                                              15    9605
NP_001139020                                                           15    9605
NP_653267                                                              15    9605
NP_001166945                                                           15    9605
NP_001166944                                                           15    9605
NP_001028752                                                           15    9605
NP_079385                                                              15    9605
NP_001008781                                                           15    9605
NP_001157207                                                           15    9605
NP_001139475                                                           15    9605
XP_006725415                                                           15    9605
XP_006725414                                                           15    9605
XP_005274840                                                           15    9605
XP_005274491                                                           15    9605
XP_006722171                                                           15    9605
XP_006722170                                                           15    9605
XP_005257543                                                           15    9605
XP_006722028                                                           15    9605
XP_005257542                                                           15    9605
XP_006722027                                                           15    9605
XP_005257541                                                           15    9605
XP_005257540                                                           15    9605
XP_005257539                                                           15    9605
XP_006718827                                                           15    9605
XP_006717982                                                           15    9605
XP_006717981                                                           15    9605
XP_006717980                                                           15    9605
XP_005267039                                                           15    9605
XP_005267038                                                           15    9605
XP_005265997                                                           15    9605
XP_006714954                                                           15    9605
XP_006714335                                                           15    9605
XP_006714334                                                           15    9605
XP_006714333                                                           15    9605
XP_005263193                                                           15    9605
XP_006714332                                                           15    9605
XP_005263192                                                           15    9605
XP_006714331                                                           15    9605
XP_005263188                                                           15    9605
XP_005263187                                                           15    9605
XP_005263186                                                           15    9605
XP_006714330                                                           15    9605
>NP_036462
          Length = 2073

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISACTLKVN 9
           ISA TLKVN
Sbjct: 420 ISASTLKVN 428
>NP_001243397
          Length = 1890

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISACTLKVN 9
           ISA TLKVN
Sbjct: 420 ISASTLKVN 428
>XP_005269721
          Length = 2073

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ISACTLKVN 9
           ISA TLKVN
Sbjct: 420 ISASTLKVN 428
>NP_001007091
          Length = 319

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SACTLKVN 9
           S CT+K+N
Sbjct: 124 SYCTMKIN 131
>NP_000161
          Length = 1020

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ISACTLKVN 9
           + +CT+K+N
Sbjct: 555 LGSCTMKLN 563
>NP_689571
          Length = 221

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ISACTLKVN 9
           +SACT + N
Sbjct: 207 VSACTYRQN 215
>XP_006723071
          Length = 214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ISACTLKVN 9
           +SACT + N
Sbjct: 200 VSACTYRQN 208
>NP_001127870
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   ISACTLKV 8
           +  CTLKV
Sbjct: 311 VEECTLKV 318
>NP_003362
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   ISACTLKV 8
           +  CTLKV
Sbjct: 306 VEECTLKV 313
>NP_061878
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ISACTLK 7
           +SACT K
Sbjct: 851 VSACTCK 857
>XP_005272270
          Length = 868

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   ISACTLKV 8
           +  CTLKV
Sbjct: 306 VEECTLKV 313
>XP_006717340
          Length = 857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   ISACTLKV 8
           +  CTLKV
Sbjct: 306 VEECTLKV 313
>XP_005249840
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ISACTLK 7
           +SACT K
Sbjct: 766 VSACTCK 772
>XP_005249839
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ISACTLK 7
           +SACT K
Sbjct: 851 VSACTCK 857
>XP_005249838
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ISACTLK 7
           +SACT K
Sbjct: 851 VSACTCK 857
>XP_005249837
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ISACTLK 7
           +SACT K
Sbjct: 851 VSACTCK 857
>NP_060247
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   CTLKVN 9
           CTLKV+
Sbjct: 226 CTLKVD 231
>NP_001159399
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   CTLKVN 9
           CTLKV+
Sbjct: 216 CTLKVD 221
>NP_001073291
          Length = 3118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    CTLKVN 9
            CT KVN
Sbjct: 1134 CTCKVN 1139
>NP_000417
          Length = 3122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    CTLKVN 9
            CT KVN
Sbjct: 1134 CTCKVN 1139
>NP_620447
          Length = 277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SACTLKV 8
          S CTLK+
Sbjct: 54 SDCTLKI 60
>NP_620448
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 199 SDCTLKI 205
>NP_620446
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_002741
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_001265477
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_055575
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ACTLKVN 9
           AC+LKV+
Sbjct: 134 ACSLKVD 140
>NP_620637
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_001265476
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_620634
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_002743
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_001128516
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_620709
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_620707
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_620708
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>NP_002744
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 199 SDCTLKI 205
>NP_004183
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISACTLKV 8
           ++AC LKV
Sbjct: 302 LTACKLKV 309
>NP_001139020
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SACTLK 7
           SACT+K
Sbjct: 114 SACTVK 119
>NP_653267
          Length = 4753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ISACTLKVN 9
           I+ CT K+N
Sbjct: 829 IAQCTQKLN 837
>NP_001166945
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISACTLKV 8
           ++AC LKV
Sbjct: 286 LTACKLKV 293
>NP_001166944
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISACTLKV 8
           ++AC LKV
Sbjct: 244 LTACKLKV 251
>NP_001028752
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SACTLKVN 9
           +ACTL+ N
Sbjct: 184 NACTLRNN 191
>NP_079385
          Length = 770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SACTLKVN 9
           +ACTL+ N
Sbjct: 184 NACTLRNN 191
>NP_001008781
          Length = 4557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    ISACTLKV 8
            +  CTLKV
Sbjct: 2357 VQHCTLKV 2364
>NP_001157207
          Length = 970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SACTLKVN 9
           +ACTL+ N
Sbjct: 184 NACTLRNN 191
>NP_001139475
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SACTLK 7
           S+CTLK
Sbjct: 591 SSCTLK 596
>XP_006725415
          Length = 990

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SACTLKVN 9
           +ACTL+ N
Sbjct: 184 NACTLRNN 191
>XP_006725414
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SACTLKVN 9
           +ACTL+ N
Sbjct: 184 NACTLRNN 191
>XP_005274840
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISACTLKV 8
           ++AC LKV
Sbjct: 302 LTACKLKV 309
>XP_005274491
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ISACTLKV 8
           ++AC LKV
Sbjct: 302 LTACKLKV 309
>XP_006722171
          Length = 972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SACTLKVN 9
           +ACTL+ N
Sbjct: 184 NACTLRNN 191
>XP_006722170
          Length = 1016

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SACTLKVN 9
           +ACTL+ N
Sbjct: 184 NACTLRNN 191
>XP_005257543
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  CTLKVN 9
          CTLKV+
Sbjct: 23 CTLKVD 28
>XP_006722028
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  CTLKVN 9
          CTLKV+
Sbjct: 23 CTLKVD 28
>XP_005257542
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  CTLKVN 9
          CTLKV+
Sbjct: 83 CTLKVD 88
>XP_006722027
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   CTLKVN 9
           CTLKV+
Sbjct: 227 CTLKVD 232
>XP_005257541
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   CTLKVN 9
           CTLKV+
Sbjct: 227 CTLKVD 232
>XP_005257540
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   CTLKVN 9
           CTLKV+
Sbjct: 226 CTLKVD 231
>XP_005257539
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   CTLKVN 9
           CTLKV+
Sbjct: 227 CTLKVD 232
>XP_006718827
          Length = 3479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    ISACTLKV 8
            +  CTLKV
Sbjct: 1247 VQHCTLKV 1254
>XP_006717982
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>XP_006717981
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>XP_006717980
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>XP_005267039
          Length = 3206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    CTLKVN 9
            CT KVN
Sbjct: 1222 CTCKVN 1227
>XP_005267038
          Length = 3210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    CTLKVN 9
            CT KVN
Sbjct: 1222 CTCKVN 1227
>XP_005265997
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 135 SDCTLKI 141
>XP_006714954
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>XP_006714335
          Length = 245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 199 SDCTLKI 205
>XP_006714334
          Length = 245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 199 SDCTLKI 205
>XP_006714333
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SACTLKV 8
          S CTLK+
Sbjct: 54 SDCTLKI 60
>XP_005263193
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SACTLKV 8
          S CTLK+
Sbjct: 54 SDCTLKI 60
>XP_006714332
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 199 SDCTLKI 205
>XP_005263192
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 199 SDCTLKI 205
>XP_006714331
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 161 SDCTLKI 167
>XP_005263188
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 199 SDCTLKI 205
>XP_005263187
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 199 SDCTLKI 205
>XP_005263186
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 199 SDCTLKI 205
>XP_006714330
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SACTLKV 8
           S CTLK+
Sbjct: 199 SDCTLKI 205
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.126    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 571,281
Number of extensions: 624
Number of successful extensions: 77
Number of sequences better than 10000.0: 77
Number of HSP's gapped: 77
Number of HSP's successfully gapped: 77
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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