Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002040                                                              18    1935
NP_001271132                                                           17    3301
NP_001092095                                                           17    3301
NP_001271131                                                           17    3301
NP_057559                                                              17    3301
NP_001271130                                                           17    3301
NP_001124390                                                           17    3301
XP_006721893                                                           17    3301
XP_006721892                                                           17    3301
XP_006721891                                                           17    3301
XP_006721890                                                           17    3301
NP_008835                                                              16    5631
NP_001075109                                                           16    5631
NP_001009984                                                           16    5631
NP_002241                                                              16    5631
NP_005101                                                              16    5631
NP_001165214                                                           16    5631
NP_001165212                                                           16    5631
NP_001165211                                                           16    5631
XP_005260744                                                           16    5631
XP_006723620                                                           16    5631
XP_006723619                                                           16    5631
XP_005260741                                                           16    5631
XP_005258943                                                           16    5631
XP_005258939                                                           16    5631
XP_006715005                                                           16    5631
XP_006713250                                                           16    5631
NP_057294                                                              16    5631
NP_116204                                                              16    5631
NP_694546                                                              16    7355
NP_006494                                                              16    7355
NP_001268917                                                           16    7355
NP_001268916                                                           16    7355
NP_659431                                                              16    7355
NP_653170                                                              16    7355
XP_006711094                                                           16    7355
XP_006711093                                                           16    7355
XP_006711092                                                           16    7355
XP_006711091                                                           16    7355
NP_006256                                                              15    9605
NP_079279                                                              15    9605
NP_006791                                                              15    9605
NP_001269103                                                           15    9605
NP_001180199                                                           15    9605
NP_523352                                                              15    9605
NP_523353                                                              15    9605
NP_004229                                                              15    9605
NP_001271144                                                           15    9605
NP_001277060                                                           15    9605
NP_001028733                                                           15    9605
NP_001271143                                                           15    9605
NP_001271145                                                           15    9605
NP_065940                                                              15    9605
NP_057662                                                              15    9605
XP_005274497                                                           15    9605
XP_006724524                                                           15    9605
XP_005258072                                                           15    9605
XP_005274108                                                           15    9605
XP_006712916                                                           15    9605
XP_005247020                                                           15    9605
XP_005247019                                                           15    9605
XP_006712915                                                           15    9605
XP_005247018                                                           15    9605
XP_005247017                                                           15    9605
XP_005247015                                                           15    9605
XP_005247014                                                           15    9605
XP_005247013                                                           15    9605
XP_005247012                                                           15    9605
XP_005247011                                                           15    9605
NP_001167579                                                           15    9605
NP_695003                                                              15    9605
>NP_002040
          Length = 413

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           IR KKRLIV
Sbjct: 242 IRPKKRLIV 250
>NP_001271132
          Length = 248

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   RKKRLIV 9
           RKKRLIV
Sbjct: 184 RKKRLIV 190
>NP_001092095
          Length = 305

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   RKKRLIV 9
           RKKRLIV
Sbjct: 241 RKKRLIV 247
>NP_001271131
          Length = 319

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   RKKRLIV 9
           RKKRLIV
Sbjct: 255 RKKRLIV 261
>NP_057559
          Length = 311

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   RKKRLIV 9
           RKKRLIV
Sbjct: 247 RKKRLIV 253
>NP_001271130
          Length = 325

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   RKKRLIV 9
           RKKRLIV
Sbjct: 261 RKKRLIV 267
>NP_001124390
          Length = 891

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRKKRLIV 9
           R+KKRL++
Sbjct: 104 RKKKRLVI 111
>XP_006721893
          Length = 713

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRKKRLIV 9
           R+KKRL++
Sbjct: 104 RKKKRLVI 111
>XP_006721892
          Length = 843

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RRKKRLIV 9
          R+KKRL++
Sbjct: 56 RKKKRLVI 63
>XP_006721891
          Length = 891

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRKKRLIV 9
           R+KKRL++
Sbjct: 104 RKKKRLVI 111
>XP_006721890
          Length = 891

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRKKRLIV 9
           R+KKRL++
Sbjct: 104 RKKKRLVI 111
>NP_008835
          Length = 4128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    IRRKKRLIV 9
            +RR KR+I+
Sbjct: 3732 LRRPKRIII 3740
>NP_001075109
          Length = 4097

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    IRRKKRLIV 9
            +RR KR+I+
Sbjct: 3732 LRRPKRIII 3740
>NP_001009984
          Length = 1177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           IR+K RL+V
Sbjct: 817 IRKKTRLLV 825
>NP_002241
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  IRRKKRLI 8
          +RR+KRL+
Sbjct: 12 LRRRKRLL 19
>NP_005101
          Length = 682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           IRR +RLIV
Sbjct: 364 IRRCRRLIV 372
>NP_001165214
          Length = 142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRRKKRL 7
          IR+KKRL
Sbjct: 62 IRKKKRL 68
>NP_001165212
          Length = 162

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRRKKRL 7
          IR+KKRL
Sbjct: 82 IRKKKRL 88
>NP_001165211
          Length = 162

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRRKKRL 7
          IR+KKRL
Sbjct: 82 IRKKKRL 88
>XP_005260744
          Length = 592

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           IR+K RL+V
Sbjct: 232 IRKKTRLLV 240
>XP_006723620
          Length = 874

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           IR+K RL+V
Sbjct: 817 IRKKTRLLV 825
>XP_006723619
          Length = 1151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           IR+K RL+V
Sbjct: 791 IRKKTRLLV 799
>XP_005260741
          Length = 1176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           IR+K RL+V
Sbjct: 816 IRKKTRLLV 824
>XP_005258943
          Length = 251

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  IRRKKRLI 8
          +RR+KRL+
Sbjct: 12 LRRRKRLL 19
>XP_005258939
          Length = 395

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  IRRKKRLI 8
          +RR+KRL+
Sbjct: 12 LRRRKRLL 19
>XP_006715005
          Length = 628

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           IRR +RLIV
Sbjct: 364 IRRCRRLIV 372
>XP_006713250
          Length = 142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRRKKRL 7
          IR+KKRL
Sbjct: 62 IRKKKRL 68
>NP_057294
          Length = 162

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRRKKRL 7
          IR+KKRL
Sbjct: 82 IRKKKRL 88
>NP_116204
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IRRKKRLIV 9
           +RR++RL++
Sbjct: 107 VRRRRRLVL 115
>NP_694546
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRKKRLI 8
           RR+KRLI
Sbjct: 307 RRQKRLI 313
>NP_006494
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRKKRLI 8
           RR+KRLI
Sbjct: 338 RRQKRLI 344
>NP_001268917
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  IRRKKRLIV 9
          +RRKKR +V
Sbjct: 12 LRRKKRPMV 20
>NP_001268916
          Length = 1203

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           +RRKKR +V
Sbjct: 519 LRRKKRPMV 527
>NP_659431
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  RRKKRL 7
          RRKKRL
Sbjct: 81 RRKKRL 86
>NP_653170
          Length = 1216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           +RRKKR +V
Sbjct: 519 LRRKKRPMV 527
>XP_006711094
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           +RRKKR +V
Sbjct: 248 LRRKKRPMV 256
>XP_006711093
          Length = 946

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           +RRKKR +V
Sbjct: 262 LRRKKRPMV 270
>XP_006711092
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           +RRKKR +V
Sbjct: 519 LRRKKRPMV 527
>XP_006711091
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IRRKKRLIV 9
           +RRKKR +V
Sbjct: 519 LRRKKRPMV 527
>NP_006256
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRKKRLIV 9
           +RK++LIV
Sbjct: 319 KRKRKLIV 326
>NP_079279
          Length = 1910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RKKRLI 8
           RKKRLI
Sbjct: 250 RKKRLI 255
>NP_006791
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IRRKKRLI 8
          I R+KRL+
Sbjct: 25 INRRKRLV 32
>NP_001269103
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IRRKKRLI 8
          I R+KRL+
Sbjct: 42 INRRKRLV 49
>NP_001180199
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IRRKKRLI 8
           I R+KRL+
Sbjct: 179 INRRKRLV 186
>NP_523352
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IRRKKRLI 8
           I R+KRL+
Sbjct: 191 INRRKRLV 198
>NP_523353
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IRRKKRLI 8
           I R+KRL+
Sbjct: 191 INRRKRLV 198
>NP_004229
          Length = 1992

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1756 VRQKKRL 1762
>NP_001271144
          Length = 2025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1789 VRQKKRL 1795
>NP_001277060
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IRRKKR 6
           +RRKKR
Sbjct: 104 VRRKKR 109
>NP_001028733
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IRRKKR 6
           +RRKKR
Sbjct: 104 VRRKKR 109
>NP_001271143
          Length = 2040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1804 VRQKKRL 1810
>NP_001271145
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1486 VRQKKRL 1492
>NP_065940
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IRRKKR 6
           +RRKKR
Sbjct: 104 VRRKKR 109
>NP_057662
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRKKRLI 8
           RRK+RL+
Sbjct: 966 RRKERLV 972
>XP_005274497
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IRRKKRLI 8
          I R+KRL+
Sbjct: 25 INRRKRLV 32
>XP_006724524
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IRRKKRLI 8
          I R+KRL+
Sbjct: 42 INRRKRLV 49
>XP_005258072
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  IRRKKR 6
          +RRKKR
Sbjct: 14 VRRKKR 19
>XP_005274108
          Length = 1438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRKKRLI 8
           RRK+RL+
Sbjct: 963 RRKERLV 969
>XP_006712916
          Length = 1998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1762 VRQKKRL 1768
>XP_005247020
          Length = 2013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1832 VRQKKRL 1838
>XP_005247019
          Length = 2025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1789 VRQKKRL 1795
>XP_006712915
          Length = 2026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1790 VRQKKRL 1796
>XP_005247018
          Length = 2026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1790 VRQKKRL 1796
>XP_005247017
          Length = 2039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1803 VRQKKRL 1809
>XP_005247015
          Length = 2041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1805 VRQKKRL 1811
>XP_005247014
          Length = 2063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1827 VRQKKRL 1833
>XP_005247013
          Length = 2067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1831 VRQKKRL 1837
>XP_005247012
          Length = 2068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1832 VRQKKRL 1838
>XP_005247011
          Length = 2068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    IRRKKRL 7
            +R+KKRL
Sbjct: 1832 VRQKKRL 1838
>NP_001167579
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RRKKRLIV 9
          RR+K+LI+
Sbjct: 74 RRRKKLIL 81
>NP_695003
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RRKKRLIV 9
           +RK+RLI+
Sbjct: 305 KRKRRLIL 312
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.349    0.161    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 571,873
Number of extensions: 999
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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