Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_612369                                                              18    1935
NP_061031                                                              17    2528
NP_001273483                                                           17    2528
NP_001073996                                                           17    3301
XP_006712602                                                           17    3301
XP_006726512                                                           17    4312
XP_006725120                                                           17    4312
XP_005250800                                                           17    4312
XP_005250799                                                           17    4312
XP_006716274                                                           17    4312
NP_001180438                                                           16    5631
NP_060205                                                              16    5631
NP_078815                                                              16    5631
XP_005264473                                                           16    5631
NP_060426                                                              16    5631
NP_919445                                                              16    5631
NP_054878                                                              16    7355
NP_071349                                                              16    7355
NP_001123537                                                           16    7355
NP_001135973                                                           16    7355
NP_115731                                                              16    7355
NP_004136                                                              16    7355
XP_006722821                                                           16    7355
XP_006722820                                                           16    7355
XP_005259972                                                           16    7355
XP_006722819                                                           16    7355
XP_006722818                                                           16    7355
XP_005257625                                                           16    7355
XP_005257624                                                           16    7355
XP_005255063                                                           16    7355
XP_005265151                                                           16    7355
XP_006713182                                                           16    7355
NP_000543                                                              15    9605
NP_056160                                                              15    9605
NP_001188356                                                           15    9605
NP_065816                                                              15    9605
NP_001257449                                                           15    9605
NP_055807                                                              15    9605
NP_002821                                                              15    9605
NP_001077005                                                           15    9605
NP_149077                                                              15    9605
NP_005376                                                              15    9605
NP_001273922                                                           15    9605
XP_005267488                                                           15    9605
XP_005267487                                                           15    9605
XP_006715109                                                           15    9605
XP_006715108                                                           15    9605
XP_006715107                                                           15    9605
XP_006715106                                                           15    9605
XP_006715105                                                           15    9605
XP_006715104                                                           15    9605
XP_006715103                                                           15    9605
XP_006715102                                                           15    9605
XP_005265233                                                           15    9605
XP_005265231                                                           15    9605
XP_006713237                                                           15    9605
XP_006713236                                                           15    9605
XP_006713235                                                           15    9605
XP_006713234                                                           15    9605
XP_005265230                                                           15    9605
XP_006710573                                                           15    9605
XP_006710572                                                           15    9605
XP_006710571                                                           15    9605
XP_006710570                                                           15    9605
XP_006710569                                                           15    9605
XP_006710568                                                           15    9605
XP_006710567                                                           15    9605
XP_006710566                                                           15    9605
XP_005245859                                                           15    9605
>NP_612369
          Length = 1372

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RNKRAQSC 9
            R +RAQSC
Sbjct: 1343 RTRRAQSC 1350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           +RN  +Q+C
Sbjct: 660 VRNNHSQTC 668
>NP_061031
          Length = 640

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IRNKRAQSC 9
           +RN RA++C
Sbjct: 317 LRNDRAEAC 325
>NP_001273483
          Length = 688

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IRNKRAQSC 9
           +RN RA++C
Sbjct: 317 LRNDRAEAC 325
>NP_001073996
          Length = 2116

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RNKRAQSC 9
           RNKR Q C
Sbjct: 147 RNKRDQCC 154
>XP_006712602
          Length = 2142

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RNKRAQSC 9
           RNKR Q C
Sbjct: 147 RNKRDQCC 154
>XP_006726512
          Length = 335

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           +RN+R Q C
Sbjct: 267 VRNRRFQLC 275
>XP_006725120
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           +RN+R Q C
Sbjct: 244 VRNRRFQLC 252
>XP_005250800
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           +RN+R Q C
Sbjct: 244 VRNRRFQLC 252
>XP_005250799
          Length = 352

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           +RN+R Q C
Sbjct: 284 VRNRRFQLC 292
>XP_006716274
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           +RN+R Q C
Sbjct: 244 VRNRRFQLC 252
>NP_001180438
          Length = 793

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   IRNKRAQSC 9
           +RNK  Q C
Sbjct: 488 LRNKEFQEC 496
>NP_060205
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   IRNKRAQSC 9
           +RNK  Q C
Sbjct: 538 LRNKEFQEC 546
>NP_078815
          Length = 402

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IRNKRAQS 8
           +RN RAQS
Sbjct: 208 LRNARAQS 215
>XP_005264473
          Length = 802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   IRNKRAQSC 9
           +RNK  Q C
Sbjct: 497 LRNKEFQEC 505
>NP_060426
          Length = 448

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           + +KRAQ C
Sbjct: 93  VPSKRAQGC 101
>NP_919445
          Length = 428

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IRNKRAQS 8
           +RN RAQS
Sbjct: 234 LRNARAQS 241
>NP_054878
          Length = 2564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IRNKRAQSC 9
            I+N  +QSC
Sbjct: 1758 IQNTHSQSC 1766
>NP_071349
          Length = 1292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NKRAQSC 9
           +KR QSC
Sbjct: 592 DKRVQSC 598
>NP_001123537
          Length = 2022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RNKRAQSC 9
            +NK  QSC
Sbjct: 1162 QNKHIQSC 1169
>NP_001135973
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IRNKRAQ 7
          +RN+RAQ
Sbjct: 90 LRNRRAQ 96
>NP_115731
          Length = 652

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IRNKRAQ 7
          +RN+RAQ
Sbjct: 90 LRNRRAQ 96
>NP_004136
          Length = 2157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RNKRAQSC 9
            +NK  QSC
Sbjct: 1162 QNKHIQSC 1169
>XP_006722821
          Length = 1462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RNKRAQSC 9
            +NK  QSC
Sbjct: 1162 QNKHIQSC 1169
>XP_006722820
          Length = 2140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RNKRAQSC 9
            +NK  QSC
Sbjct: 1162 QNKHIQSC 1169
>XP_005259972
          Length = 2141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RNKRAQSC 9
            +NK  QSC
Sbjct: 1162 QNKHIQSC 1169
>XP_006722819
          Length = 2156

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RNKRAQSC 9
            +NK  QSC
Sbjct: 1162 QNKHIQSC 1169
>XP_006722818
          Length = 2157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    RNKRAQSC 9
            +NK  QSC
Sbjct: 1162 QNKHIQSC 1169
>XP_005257625
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NKRAQSC 9
           +KR QSC
Sbjct: 567 DKRVQSC 573
>XP_005257624
          Length = 1293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NKRAQSC 9
           +KR QSC
Sbjct: 592 DKRVQSC 598
>XP_005255063
          Length = 970

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RNKRAQSC 9
           RN  +QSC
Sbjct: 950 RNSSSQSC 957
>XP_005265151
          Length = 2058

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IRNKRAQSC 9
            I+N  +QSC
Sbjct: 1758 IQNTHSQSC 1766
>XP_006713182
          Length = 2422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IRNKRAQSC 9
            I+N  +QSC
Sbjct: 1758 IQNTHSQSC 1766
>NP_000543
          Length = 2813

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RNKRAQSC 9
           R+KR+ SC
Sbjct: 760 RSKRSLSC 767
>NP_056160
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 673 IDGRRAQNC 681
>NP_001188356
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 673 IDGRRAQNC 681
>NP_065816
          Length = 5183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IRNKRAQSC 9
            I+NK  Q C
Sbjct: 4386 IKNKICQDC 4394
>NP_001257449
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 678 IDGRRAQNC 686
>NP_055807
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 688 IDGRRAQNC 696
>NP_002821
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IRNKRA 6
           +RNKRA
Sbjct: 837 VRNKRA 842
>NP_001077005
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RNKRAQSC 9
           R+K  QSC
Sbjct: 531 RDKEKQSC 538
>NP_149077
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RNKRAQSC 9
           R+K  QSC
Sbjct: 531 RDKEKQSC 538
>NP_005376
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    NKRAQSC 9
            N+R++SC
Sbjct: 1430 NRRSRSC 1436
>NP_001273922
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RNKRAQSC 9
           R+K  QSC
Sbjct: 531 RDKEKQSC 538
>XP_005267488
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 688 IDGRRAQNC 696
>XP_005267487
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 688 IDGRRAQNC 696
>XP_006715109
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 682 IDGRRAQNC 690
>XP_006715108
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 682 IDGRRAQNC 690
>XP_006715107
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 682 IDGRRAQNC 690
>XP_006715106
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 682 IDGRRAQNC 690
>XP_006715105
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 682 IDGRRAQNC 690
>XP_006715104
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 716 IDGRRAQNC 724
>XP_006715103
          Length = 1167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 772 IDGRRAQNC 780
>XP_006715102
          Length = 1176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IRNKRAQSC 9
           I  +RAQ+C
Sbjct: 781 IDGRRAQNC 789
>XP_005265233
          Length = 1163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    NKRAQSC 9
            N+R++SC
Sbjct: 1131 NRRSRSC 1137
>XP_005265231
          Length = 1210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    NKRAQSC 9
            N+R++SC
Sbjct: 1178 NRRSRSC 1184
>XP_006713237
          Length = 1353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    NKRAQSC 9
            N+R++SC
Sbjct: 1321 NRRSRSC 1327
>XP_006713236
          Length = 1353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    NKRAQSC 9
            N+R++SC
Sbjct: 1321 NRRSRSC 1327
>XP_006713235
          Length = 1353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    NKRAQSC 9
            N+R++SC
Sbjct: 1321 NRRSRSC 1327
>XP_006713234
          Length = 1436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    NKRAQSC 9
            N+R++SC
Sbjct: 1404 NRRSRSC 1410
>XP_005265230
          Length = 1463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    NKRAQSC 9
            N+R++SC
Sbjct: 1431 NRRSRSC 1437
>XP_006710573
          Length = 5177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IRNKRAQSC 9
            I+NK  Q C
Sbjct: 4380 IKNKICQDC 4388
>XP_006710572
          Length = 5188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IRNKRAQSC 9
            I+NK  Q C
Sbjct: 4391 IKNKICQDC 4399
>XP_006710571
          Length = 5194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IRNKRAQSC 9
            I+NK  Q C
Sbjct: 4397 IKNKICQDC 4405
>XP_006710570
          Length = 5195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IRNKRAQSC 9
            I+NK  Q C
Sbjct: 4398 IKNKICQDC 4406
>XP_006710569
          Length = 5212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IRNKRAQSC 9
            I+NK  Q C
Sbjct: 4415 IKNKICQDC 4423
>XP_006710568
          Length = 5221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IRNKRAQSC 9
            I+NK  Q C
Sbjct: 4424 IKNKICQDC 4432
>XP_006710567
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IRNKRAQSC 9
            I+NK  Q C
Sbjct: 4425 IKNKICQDC 4433
>XP_006710566
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IRNKRAQSC 9
            I+NK  Q C
Sbjct: 4425 IKNKICQDC 4433
>XP_005245859
          Length = 5223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IRNKRAQSC 9
            I+NK  Q C
Sbjct: 4426 IKNKICQDC 4434
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.125    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 471,968
Number of extensions: 755
Number of successful extensions: 70
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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