Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001098714                                                           17    2528
XP_006722401                                                           17    2528
XP_006722400                                                           17    2528
XP_006722399                                                           17    2528
XP_006722398                                                           17    2528
NP_002836                                                              17    2528
NP_695001                                                              17    3301
NP_542138                                                              17    3301
XP_005260723                                                           17    3301
XP_006723606                                                           17    3301
NP_001171826                                                           17    4312
NP_055922                                                              17    4312
NP_001171825                                                           17    4312
NP_001171827                                                           17    4312
XP_006724648                                                           17    4312
XP_005262057                                                           17    4312
XP_005262055                                                           17    4312
XP_005262056                                                           17    4312
XP_005262054                                                           17    4312
XP_005262053                                                           17    4312
NP_001243415                                                           16    5631
NP_001243417                                                           16    5631
NP_004478                                                              16    5631
NP_001243416                                                           16    5631
XP_006713654                                                           16    5631
XP_006713653                                                           16    5631
XP_005247430                                                           16    5631
XP_005247429                                                           16    5631
XP_006713652                                                           16    5631
XP_006713651                                                           16    5631
XP_006713650                                                           16    5631
XP_005247428                                                           16    5631
NP_005393                                                              16    7355
NP_055864                                                              16    7355
NP_036395                                                              16    7355
NP_085150                                                              16    7355
XP_006724288                                                           16    7355
XP_006717206                                                           16    7355
XP_005252108                                                           16    7355
XP_006715826                                                           16    7355
XP_006715825                                                           16    7355
XP_006712777                                                           16    7355
NP_005383                                                              16    7355
NP_006333                                                              15    9605
NP_001135919                                                           15    9605
NP_001138600                                                           15    9605
NP_036201                                                              15    9605
NP_056247                                                              15    9605
NP_663780                                                              15    9605
NP_055625                                                              15    9605
NP_056101                                                              15    9605
NP_057257                                                              15    9605
NP_001123203                                                           15    9605
NP_112557                                                              15    9605
NP_003709                                                              15    9605
NP_003159                                                              15    9605
NP_060417                                                              15    9605
XP_006715439                                                           15    9605
XP_005247987                                                           15    9605
XP_006713918                                                           15    9605
XP_005247986                                                           15    9605
XP_005265275                                                           15    9605
XP_006711734                                                           15    9605
XP_006711733                                                           15    9605
XP_006711732                                                           15    9605
XP_006711731                                                           15    9605
XP_006711730                                                           15    9605
XP_006711729                                                           15    9605
XP_005245695                                                           15    9605
NP_001123199                                                           15    9605
NP_001123200                                                           15    9605
NP_001123201                                                           15    9605
>NP_001098714
          Length = 1465

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    IRELRSRK 8
            +RELRSR+
Sbjct: 1140 VRELRSRR 1147
>XP_006722401
          Length = 1432

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    IRELRSRK 8
            +RELRSR+
Sbjct: 1107 VRELRSRR 1114
>XP_006722400
          Length = 1469

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    IRELRSRK 8
            +RELRSR+
Sbjct: 1144 VRELRSRR 1151
>XP_006722399
          Length = 1477

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    IRELRSRK 8
            +RELRSR+
Sbjct: 1152 VRELRSRR 1159
>XP_006722398
          Length = 1494

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    IRELRSRK 8
            +RELRSR+
Sbjct: 1169 VRELRSRR 1176
>NP_002836
          Length = 1452

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    IRELRSRK 8
            +RELRSR+
Sbjct: 1127 VRELRSRR 1134
>NP_695001
          Length = 363

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   IRELRSRKS 9
           +RELRSR++
Sbjct: 112 LRELRSREN 120
>NP_542138
          Length = 362

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   IRELRSRKS 9
           +RELRSR++
Sbjct: 111 LRELRSREN 119
>XP_005260723
          Length = 279

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  IRELRSRKS 9
          +RELRSR++
Sbjct: 77 LRELRSREN 85
>XP_006723606
          Length = 310

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  IRELRSRKS 9
          +RELRSR++
Sbjct: 59 LRELRSREN 67
>NP_001171826
          Length = 948

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRELRSR 7
          +RELRSR
Sbjct: 88 VRELRSR 94
>NP_055922
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRELRSR 7
          +RELRSR
Sbjct: 88 VRELRSR 94
>NP_001171825
          Length = 1060

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IRELRSR 7
           +RELRSR
Sbjct: 124 VRELRSR 130
>NP_001171827
          Length = 878

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRELRSR 7
          +RELRSR
Sbjct: 88 VRELRSR 94
>XP_006724648
          Length = 931

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IRELRSR 7
           +RELRSR
Sbjct: 124 VRELRSR 130
>XP_005262057
          Length = 984

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IRELRSR 7
           +RELRSR
Sbjct: 124 VRELRSR 130
>XP_005262055
          Length = 1049

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRELRSR 7
          +RELRSR
Sbjct: 88 VRELRSR 94
>XP_005262056
          Length = 1049

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRELRSR 7
          +RELRSR
Sbjct: 88 VRELRSR 94
>XP_005262054
          Length = 1049

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRELRSR 7
          +RELRSR
Sbjct: 88 VRELRSR 94
>XP_005262053
          Length = 1085

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IRELRSR 7
           +RELRSR
Sbjct: 124 VRELRSR 130
>NP_001243415
          Length = 3269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2993 IRELRSSSS 3001
>NP_001243417
          Length = 3184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2913 IRELRSSSS 2921
>NP_004478
          Length = 3259

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2988 IRELRSSSS 2996
>NP_001243416
          Length = 3225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2954 IRELRSSSS 2962
>XP_006713654
          Length = 3189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2913 IRELRSSSS 2921
>XP_006713653
          Length = 3223

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2952 IRELRSSSS 2960
>XP_005247430
          Length = 3228

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2952 IRELRSSSS 2960
>XP_005247429
          Length = 3230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2954 IRELRSSSS 2962
>XP_006713652
          Length = 3263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2987 IRELRSSSS 2995
>XP_006713651
          Length = 3264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2988 IRELRSSSS 2996
>XP_006713650
          Length = 3264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2993 IRELRSSSS 3001
>XP_005247428
          Length = 3269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IRELRSRKS 9
            IRELRS  S
Sbjct: 2993 IRELRSSSS 3001
>NP_005393
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IRELRSRK 8
           +RE+R+RK
Sbjct: 172 MREIRARK 179
>NP_055864
          Length = 914

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IRELRSR 7
           I+ELRSR
Sbjct: 347 IKELRSR 353
>NP_036395
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RELRSRK 8
           RELRSR+
Sbjct: 394 RELRSRQ 400
>NP_085150
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IRELRSR 7
           I+ELRSR
Sbjct: 123 IKELRSR 129
>XP_006724288
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RELRSRK 8
           RELRSR+
Sbjct: 297 RELRSRQ 303
>XP_006717206
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRELRSR 7
          I+ELRSR
Sbjct: 90 IKELRSR 96
>XP_005252108
          Length = 1097

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRELRSR 7
          I+ELRSR
Sbjct: 90 IKELRSR 96
>XP_006715826
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IRELRSRK 8
           +RE+R+RK
Sbjct: 172 MREIRARK 179
>XP_006715825
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IRELRSRK 8
           +RE+R+RK
Sbjct: 172 MREIRARK 179
>XP_006712777
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IRELRSR 7
           I+ELRSR
Sbjct: 136 IKELRSR 142
>NP_005383
          Length = 1096

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  IRELRSR 7
          I+ELRSR
Sbjct: 90 IKELRSR 96
>NP_006333
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RELRSR 7
           RELRSR
Sbjct: 656 RELRSR 661
>NP_001135919
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RELRSRKS 9
          R+LRSR++
Sbjct: 3  RQLRSRRA 10
>NP_001138600
          Length = 1911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IRELRSRK 8
           +REL++RK
Sbjct: 458 LRELQARK 465
>NP_036201
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RELRSRKS 9
          R+LRSR++
Sbjct: 3  RQLRSRRA 10
>NP_056247
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RELRSRKS 9
            RE+RSR S
Sbjct: 1073 REVRSRAS 1080
>NP_663780
          Length = 1565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IRELRSR 7
           +RELR+R
Sbjct: 152 VRELRAR 158
>NP_055625
          Length = 3117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ELRSRKS 9
            ELR RKS
Sbjct: 2060 ELRKRKS 2066
>NP_056101
          Length = 1253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IRELRSR 7
           +RELR+R
Sbjct: 152 VRELRAR 158
>NP_057257
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IRELRSRK 8
           IREL SR+
Sbjct: 97  IRELSSRR 104
>NP_001123203
          Length = 1110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RELRSRKS 9
           RE+RSR S
Sbjct: 992 REVRSRAS 999
>NP_112557
          Length = 1452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RELRSRKS 9
           + LRSRKS
Sbjct: 333 QSLRSRKS 340
>NP_003709
          Length = 1512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RELRSRKS 9
           + LRSRKS
Sbjct: 333 QSLRSRKS 340
>NP_003159
          Length = 117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IRELRSR 7
           +REL+SR
Sbjct: 98  VRELKSR 104
>NP_060417
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  IRELRSRK 8
          +RELR+R+
Sbjct: 35 LRELRARE 42
>XP_006715439
          Length = 1911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IRELRSRK 8
           +REL++RK
Sbjct: 458 LRELQARK 465
>XP_005247987
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RELRSR 7
           RELRSR
Sbjct: 300 RELRSR 305
>XP_006713918
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RELRSR 7
           RELRSR
Sbjct: 648 RELRSR 653
>XP_005247986
          Length = 842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RELRSR 7
           RELRSR
Sbjct: 660 RELRSR 665
>XP_005265275
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IRELRSRK 8
           IREL SR+
Sbjct: 97  IRELSSRR 104
>XP_006711734
          Length = 3136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ELRSRKS 9
            ELR RKS
Sbjct: 2079 ELRKRKS 2085
>XP_006711733
          Length = 3137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ELRSRKS 9
            ELR RKS
Sbjct: 2080 ELRKRKS 2086
>XP_006711732
          Length = 3154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ELRSRKS 9
            ELR RKS
Sbjct: 2097 ELRKRKS 2103
>XP_006711731
          Length = 3157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ELRSRKS 9
            ELR RKS
Sbjct: 2100 ELRKRKS 2106
>XP_006711730
          Length = 3157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ELRSRKS 9
            ELR RKS
Sbjct: 2100 ELRKRKS 2106
>XP_006711729
          Length = 3158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ELRSRKS 9
            ELR RKS
Sbjct: 2101 ELRKRKS 2107
>XP_005245695
          Length = 3158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ELRSRKS 9
            ELR RKS
Sbjct: 2101 ELRKRKS 2107
>NP_001123199
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RELRSRKS 9
            RE+RSR S
Sbjct: 1073 REVRSRAS 1080
>NP_001123200
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RELRSRKS 9
            RE+RSR S
Sbjct: 1073 REVRSRAS 1080
>NP_001123201
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RELRSRKS 9
            RE+RSR S
Sbjct: 1073 REVRSRAS 1080
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.130    0.305 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 487,143
Number of extensions: 830
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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