Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_003290                                                              20     509
NP_001275514                                                           17    4312
NP_741982                                                              17    4312
NP_478060                                                              17    4312
NP_116246                                                              17    4312
XP_006724081                                                           17    4312
XP_005261206                                                           17    4312
XP_005261205                                                           17    4312
XP_005254200                                                           17    4312
XP_005268213                                                           17    4312
NP_055888                                                              16    5631
NP_001138363                                                           16    5631
NP_057670                                                              16    5631
XP_006723175                                                           16    5631
XP_005258729                                                           16    5631
XP_005258728                                                           16    5631
XP_005256244                                                           16    5631
XP_006721357                                                           16    5631
XP_006721356                                                           16    5631
XP_005267811                                                           16    5631
NP_001153685                                                           16    5631
NP_112583                                                              16    5631
NP_004509                                                              16    7355
NP_742106                                                              16    7355
NP_742105                                                              16    7355
NP_742104                                                              16    7355
NP_004510                                                              16    7355
NP_002679                                                              16    7355
NP_001191753                                                           16    7355
NP_001092906                                                           16    7355
NP_001271294                                                           16    7355
NP_001271293                                                           16    7355
XP_006723855                                                           16    7355
XP_006723854                                                           16    7355
XP_006723853                                                           16    7355
XP_006723852                                                           16    7355
XP_006723851                                                           16    7355
XP_006723850                                                           16    7355
XP_005254346                                                           16    7355
XP_005254347                                                           16    7355
XP_005250971                                                           16    7355
XP_006716618                                                           16    7355
XP_005250970                                                           16    7355
XP_006716617                                                           16    7355
XP_005245422                                                           16    7355
NP_065821                                                              16    7355
NP_115763                                                              15    9605
NP_001164192                                                           15    9605
NP_001164188                                                           15    9605
NP_001164187                                                           15    9605
NP_055382                                                              15    9605
NP_001164186                                                           15    9605
NP_001164189                                                           15    9605
NP_001164185                                                           15    9605
NP_001164190                                                           15    9605
NP_001164191                                                           15    9605
NP_542391                                                              15    9605
XP_006722085                                                           15    9605
XP_006722084                                                           15    9605
XP_005257655                                                           15    9605
XP_005257654                                                           15    9605
XP_005257653                                                           15    9605
XP_005257652                                                           15    9605
XP_006721412                                                           15    9605
XP_005256317                                                           15    9605
XP_005256316                                                           15    9605
XP_005256315                                                           15    9605
XP_006721411                                                           15    9605
XP_005250749                                                           15    9605
XP_006716239                                                           15    9605
NP_071376                                                              15    9605
>NP_003290
          Length = 803

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IRDML+RIK
Sbjct: 694 IRDMLRRIK 702
>NP_001275514
          Length = 332

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDMLQRIK 9
           RD+L RIK
Sbjct: 112 RDLLHRIK 119
>NP_741982
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDMLQRIK 9
           RD+L RIK
Sbjct: 112 RDLLHRIK 119
>NP_478060
          Length = 322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           RD+LQR++
Sbjct: 141 RDLLQRLR 148
>NP_116246
          Length = 547

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDMLQRIK 9
           RD+L RIK
Sbjct: 112 RDLLHRIK 119
>XP_006724081
          Length = 277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           RD+LQR++
Sbjct: 141 RDLLQRLR 148
>XP_005261206
          Length = 296

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           RD+LQR++
Sbjct: 141 RDLLQRLR 148
>XP_005261205
          Length = 322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           RD+LQR++
Sbjct: 141 RDLLQRLR 148
>XP_005254200
          Length = 374

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDMLQRIK 9
           RD+L RIK
Sbjct: 112 RDLLHRIK 119
>XP_005268213
          Length = 993

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +D+LQR+K
Sbjct: 573 QDLLQRVK 580
>NP_055888
          Length = 1781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR+K
Sbjct: 948 IREIVQRLK 956
>NP_001138363
          Length = 343

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDMLQRIK 9
           RD+ QRIK
Sbjct: 269 RDIYQRIK 276
>NP_057670
          Length = 344

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDMLQRIK 9
           RD+ QRIK
Sbjct: 269 RDIYQRIK 276
>XP_006723175
          Length = 1094

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR+K
Sbjct: 261 IREIVQRLK 269
>XP_005258729
          Length = 1780

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR+K
Sbjct: 948 IREIVQRLK 956
>XP_005258728
          Length = 1781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR+K
Sbjct: 948 IREIVQRLK 956
>XP_005256244
          Length = 807

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IRDMLQRIK 9
           + DML RIK
Sbjct: 584 MNDMLDRIK 592
>XP_006721357
          Length = 1017

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IRDMLQRIK 9
           + DML RIK
Sbjct: 584 MNDMLDRIK 592
>XP_006721356
          Length = 1017

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IRDMLQRIK 9
           + DML RIK
Sbjct: 584 MNDMLDRIK 592
>XP_005267811
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RDMLQRIK 9
           RD+ QRIK
Sbjct: 247 RDIYQRIK 254
>NP_001153685
          Length = 882

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IRDMLQRIK 9
           + DML RIK
Sbjct: 439 MNDMLDRIK 447
>NP_112583
          Length = 1007

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IRDMLQRIK 9
           + DML RIK
Sbjct: 584 MNDMLDRIK 592
>NP_004509
          Length = 844

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 549 DMLSRIK 555
>NP_742106
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 546 DMLSRIK 552
>NP_742105
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 577 DMLSRIK 583
>NP_742104
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 559 DMLSRIK 565
>NP_004510
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 556 DMLSRIK 562
>NP_002679
          Length = 369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           +++MLQR+K
Sbjct: 355 MQEMLQRMK 363
>NP_001191753
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 436 DMLSRIK 442
>NP_001092906
          Length = 515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RDMLQRI 8
           RD+LQR+
Sbjct: 287 RDLLQRL 293
>NP_001271294
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RDMLQRI 8
           RD+LQR+
Sbjct: 127 RDLLQRL 133
>NP_001271293
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RDMLQRI 8
           RD+LQR+
Sbjct: 287 RDLLQRL 293
>XP_006723855
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 547 DMLSRIK 553
>XP_006723854
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 549 DMLSRIK 555
>XP_006723853
          Length = 868

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 559 DMLSRIK 565
>XP_006723852
          Length = 876

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 567 DMLSRIK 573
>XP_006723851
          Length = 885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 576 DMLSRIK 582
>XP_006723850
          Length = 886

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 577 DMLSRIK 583
>XP_005254346
          Length = 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RDMLQRI 8
           RD+LQR+
Sbjct: 255 RDLLQRL 261
>XP_005254347
          Length = 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RDMLQRI 8
           RD+LQR+
Sbjct: 255 RDLLQRL 261
>XP_005250971
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 141 DMLSRIK 147
>XP_006716618
          Length = 636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 320 DMLSRIK 326
>XP_005250970
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 357 DMLSRIK 363
>XP_006716617
          Length = 763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DMLQRIK 9
           DML RIK
Sbjct: 447 DMLSRIK 453
>XP_005245422
          Length = 1203

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IRDMLQRIK 9
           +RD LQR++
Sbjct: 763 LRDKLQRLE 771
>NP_065821
          Length = 1203

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IRDMLQRIK 9
           +RD LQR++
Sbjct: 763 LRDKLQRLE 771
>NP_115763
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR++
Sbjct: 737 IREIIQRVE 745
>NP_001164192
          Length = 660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 634 QDMVERVK 641
>NP_001164188
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 862 QDMVERVK 869
>NP_001164187
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 862 QDMVERVK 869
>NP_055382
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 844 QDMVERVK 851
>NP_001164186
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 862 QDMVERVK 869
>NP_001164189
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 844 QDMVERVK 851
>NP_001164185
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 890 QDMVERVK 897
>NP_001164190
          Length = 868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 842 QDMVERVK 849
>NP_001164191
          Length = 722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 696 QDMVERVK 703
>NP_542391
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IRDMLQR 7
          +RD+LQR
Sbjct: 37 LRDVLQR 43
>XP_006722085
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR++
Sbjct: 401 IREIIQRVE 409
>XP_006722084
          Length = 943

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR++
Sbjct: 401 IREIIQRVE 409
>XP_005257655
          Length = 971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR++
Sbjct: 429 IREIIQRVE 437
>XP_005257654
          Length = 1237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR++
Sbjct: 737 IREIIQRVE 745
>XP_005257653
          Length = 1242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR++
Sbjct: 737 IREIIQRVE 745
>XP_005257652
          Length = 1279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IRDMLQRIK 9
           IR+++QR++
Sbjct: 737 IREIIQRVE 745
>XP_006721412
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 797 QDMVERVK 804
>XP_005256317
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 815 QDMVERVK 822
>XP_005256316
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 844 QDMVERVK 851
>XP_005256315
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 870 QDMVERVK 877
>XP_006721411
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RDMLQRIK 9
           +DM++R+K
Sbjct: 890 QDMVERVK 897
>XP_005250749
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IRDMLQR 7
          +RD+LQR
Sbjct: 37 LRDVLQR 43
>XP_006716239
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  IRDMLQR 7
          +RD+LQR
Sbjct: 37 LRDVLQR 43
>NP_071376
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IRDMLQRIK 9
           ++D+L R+K
Sbjct: 105 VQDLLARVK 113
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.343    0.153    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 426,393
Number of extensions: 1187
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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