Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1935
NP_001035957                                                           18    1935
XP_006721990                                                           18    1935
XP_006721989                                                           18    1935
XP_005258041                                                           18    1935
XP_006721988                                                           18    1935
XP_006721987                                                           18    1935
XP_006721986                                                           18    1935
XP_005258040                                                           18    1935
XP_006721985                                                           18    1935
NP_055859                                                              17    3301
NP_001668                                                              17    4312
NP_114475                                                              17    4312
NP_061742                                                              17    4312
NP_001188406                                                           16    5631
NP_060562                                                              16    5631
NP_690851                                                              16    5631
XP_006721355                                                           16    5631
XP_006721354                                                           16    5631
XP_006721353                                                           16    5631
XP_006721352                                                           16    5631
XP_005255298                                                           16    5631
NP_001601                                                              16    7355
XP_005253041                                                           16    7355
NP_055513                                                              15    9605
NP_064569                                                              15    9605
NP_001072                                                              15    9605
XP_005263972                                                           15    9605
XP_005263971                                                           15    9605
XP_006711904                                                           15    9605
>NP_000258
          Length = 2818

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IQVLLLTVL 9
            IQ LLLTVL
Sbjct: 2594 IQALLLTVL 2602
>NP_001035957
          Length = 2839

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IQVLLLTVL 9
            IQ LLLTVL
Sbjct: 2615 IQALLLTVL 2623
>XP_006721990
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IQVLLLTVL 9
            IQ LLLTVL
Sbjct: 2625 IQALLLTVL 2633
>XP_006721989
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IQVLLLTVL 9
            IQ LLLTVL
Sbjct: 2625 IQALLLTVL 2633
>XP_005258041
          Length = 2836

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IQVLLLTVL 9
            IQ LLLTVL
Sbjct: 2594 IQALLLTVL 2602
>XP_006721988
          Length = 2846

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IQVLLLTVL 9
            IQ LLLTVL
Sbjct: 2604 IQALLLTVL 2612
>XP_006721987
          Length = 2849

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IQVLLLTVL 9
            IQ LLLTVL
Sbjct: 2625 IQALLLTVL 2633
>XP_006721986
          Length = 2854

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IQVLLLTVL 9
            IQ LLLTVL
Sbjct: 2612 IQALLLTVL 2620
>XP_005258040
          Length = 2857

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IQVLLLTVL 9
            IQ LLLTVL
Sbjct: 2615 IQALLLTVL 2623
>XP_006721985
          Length = 2867

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IQVLLLTVL 9
            IQ LLLTVL
Sbjct: 2625 IQALLLTVL 2633
>NP_055859
          Length = 613

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   IQVLLLTVL 9
           +QVLLLT++
Sbjct: 514 VQVLLLTMM 522
>NP_001668
          Length = 303

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  IQVLLLTV 8
          IQV+LLT+
Sbjct: 54 IQVMLLTI 61
>NP_114475
          Length = 818

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2  QVLLLTVL 9
          QVLLLT+L
Sbjct: 13 QVLLLTLL 20
>NP_061742
          Length = 932

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2  QVLLLTVL 9
          QVLLLT+L
Sbjct: 13 QVLLLTLL 20
>NP_001188406
          Length = 518

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  IQVLLLTVL 9
          ++VLL+TVL
Sbjct: 10 LKVLLITVL 18
>NP_060562
          Length = 525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  IQVLLLTVL 9
          ++VLL+TVL
Sbjct: 10 LKVLLITVL 18
>NP_690851
          Length = 280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  IQVLLLTVL 9
          +QVLLL VL
Sbjct: 7  LQVLLLLVL 15
>XP_006721355
          Length = 304

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  IQVLLLTVL 9
          ++VLL+TVL
Sbjct: 10 LKVLLITVL 18
>XP_006721354
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  IQVLLLTVL 9
          ++VLL+TVL
Sbjct: 10 LKVLLITVL 18
>XP_006721353
          Length = 484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  IQVLLLTVL 9
          ++VLL+TVL
Sbjct: 10 LKVLLITVL 18
>XP_006721352
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  IQVLLLTVL 9
          ++VLL+TVL
Sbjct: 10 LKVLLITVL 18
>XP_005255298
          Length = 280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  IQVLLLTVL 9
          +QVLLL VL
Sbjct: 7  LQVLLLLVL 15
>NP_001601
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLLLTVL 9
           VLLLTVL
Sbjct: 397 VLLLTVL 403
>XP_005253041
          Length = 236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   VLLLTVL 9
           VLLLTVL
Sbjct: 210 VLLLTVL 216
>NP_055513
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLLLTVL 9
           VLLLT+L
Sbjct: 703 VLLLTIL 709
>NP_064569
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IQVLLLTVL 9
           + +LL+TVL
Sbjct: 184 LHILLITVL 192
>NP_001072
          Length = 3623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    IQVLLLT 7
            +QVLLLT
Sbjct: 1366 LQVLLLT 1372
>XP_005263972
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IQVLLLTVL 9
           + +LL+TVL
Sbjct: 184 LHILLITVL 192
>XP_005263971
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IQVLLLTVL 9
           + +LL+TVL
Sbjct: 184 LHILLITVL 192
>XP_006711904
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VLLLTVL 9
           VLLLT+L
Sbjct: 526 VLLLTIL 532
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.161    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 304,531
Number of extensions: 286
Number of successful extensions: 30
Number of sequences better than 10000.0: 30
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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