Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001264671                                                           19     869
NP_063938                                                              19     869
XP_005264490                                                           19     869
NP_005912                                                              18    1935
XP_005248577                                                           18    1935
XP_005248576                                                           18    1935
NP_005674                                                              16    5631
NP_000410                                                              16    5631
NP_690875                                                              16    5631
NP_997011                                                              16    5631
XP_005247009                                                           16    5631
NP_073751                                                              16    7355
NP_891549                                                              16    7355
NP_009149                                                              16    7355
XP_005258190                                                           16    7355
XP_005258189                                                           16    7355
XP_006722402                                                           16    7355
NP_001167579                                                           16    7355
NP_055213                                                              15    9605
NP_005948                                                              15    9605
NP_056994                                                              15    9605
NP_060334                                                              15    9605
XP_005251701                                                           15    9605
XP_005251699                                                           15    9605
XP_005251698                                                           15    9605
XP_005251697                                                           15    9605
XP_006716666                                                           15    9605
XP_006716665                                                           15    9605
XP_006713649                                                           15    9605
XP_005247417                                                           15    9605
XP_005264407                                                           15    9605
XP_005264406                                                           15    9605
XP_005264405                                                           15    9605
XP_005263520                                                           15    9605
XP_005263519                                                           15    9605
XP_005263518                                                           15    9605
XP_005263517                                                           15    9605
XP_005263515                                                           15    9605
NP_839943                                                              15    9605
>NP_001264671
          Length = 437

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  IQLVVEDTL 9
          IQLV++DTL
Sbjct: 86 IQLVIQDTL 94
>NP_063938
          Length = 512

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   IQLVVEDTL 9
           IQLV++DTL
Sbjct: 161 IQLVIQDTL 169
>XP_005264490
          Length = 454

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   IQLVVEDTL 9
           IQLV++DTL
Sbjct: 103 IQLVIQDTL 111
>NP_005912
          Length = 1512

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IQLVVEDTL 9
           IQL VEDTL
Sbjct: 869 IQLGVEDTL 877
>XP_005248577
          Length = 1349

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IQLVVEDTL 9
           IQL VEDTL
Sbjct: 706 IQLGVEDTL 714
>XP_005248576
          Length = 1375

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IQLVVEDTL 9
           IQL VEDTL
Sbjct: 732 IQLGVEDTL 740
>NP_005674
          Length = 319

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IQLVVEDT 8
           +QLV++DT
Sbjct: 307 VQLVLQDT 314
>NP_000410
          Length = 1039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   IQLVVEDTL 9
           +QL+V+D+L
Sbjct: 489 VQLLVQDSL 497
>NP_690875
          Length = 511

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   IQLVVEDT 8
           IQLV EDT
Sbjct: 339 IQLVWEDT 346
>NP_997011
          Length = 486

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   IQLVVEDT 8
           IQLV EDT
Sbjct: 339 IQLVWEDT 346
>XP_005247009
          Length = 319

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IQLVVEDT 8
           +QLV++DT
Sbjct: 307 VQLVLQDT 314
>NP_073751
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IQLVVEDT 8
           +QLV EDT
Sbjct: 219 LQLVEEDT 226
>NP_891549
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IQLVVEDT 8
           +QL VEDT
Sbjct: 334 LQLSVEDT 341
>NP_009149
          Length = 664

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IQLVVEDT 8
           +QL++EDT
Sbjct: 221 LQLLMEDT 228
>XP_005258190
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IQLVVEDT 8
          +QLV EDT
Sbjct: 72 LQLVEEDT 79
>XP_005258189
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IQLVVEDT 8
           +QLV EDT
Sbjct: 219 LQLVEEDT 226
>XP_006722402
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IQLVVEDT 8
           +QLV EDT
Sbjct: 219 LQLVEEDT 226
>NP_001167579
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IQLVVED 7
           IQ++VED
Sbjct: 415 IQMIVED 421
>NP_055213
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IQLVVED 7
           IQL+V+D
Sbjct: 244 IQLIVQD 250
>NP_005948
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VVEDTL 9
           VVEDTL
Sbjct: 635 VVEDTL 640
>NP_056994
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IQLVVEDTL 9
           IQL+ ED L
Sbjct: 413 IQLLAEDRL 421
>NP_060334
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IQLVVEDTL 9
           IQ+ +ED L
Sbjct: 342 IQIFIEDNL 350
>XP_005251701
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 IQLVVEDTL 9
         +Q +VEDT+
Sbjct: 1 MQEIVEDTM 9
>XP_005251699
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 IQLVVEDTL 9
         +Q +VEDT+
Sbjct: 1 MQEIVEDTM 9
>XP_005251698
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 IQLVVEDTL 9
         +Q +VEDT+
Sbjct: 1 MQEIVEDTM 9
>XP_005251697
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 IQLVVEDTL 9
         +Q +VEDT+
Sbjct: 1 MQEIVEDTM 9
>XP_006716666
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IQLVVEDTL 9
           IQ+ +ED L
Sbjct: 233 IQIFIEDNL 241
>XP_006716665
          Length = 943

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IQLVVEDTL 9
           IQ+ +ED L
Sbjct: 290 IQIFIEDNL 298
>XP_006713649
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IQLVVED 7
           IQL+V+D
Sbjct: 220 IQLIVQD 226
>XP_005247417
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IQLVVED 7
           IQL+V+D
Sbjct: 244 IQLIVQD 250
>XP_005264407
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IQLVVEDTL 9
           IQL+ ED L
Sbjct: 254 IQLLAEDRL 262
>XP_005264406
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IQLVVEDTL 9
           IQL+ ED L
Sbjct: 266 IQLLAEDRL 274
>XP_005264405
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IQLVVEDTL 9
           IQL+ ED L
Sbjct: 413 IQLLAEDRL 421
>XP_005263520
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VVEDTL 9
           VVEDTL
Sbjct: 553 VVEDTL 558
>XP_005263519
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VVEDTL 9
           VVEDTL
Sbjct: 635 VVEDTL 640
>XP_005263518
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VVEDTL 9
           VVEDTL
Sbjct: 635 VVEDTL 640
>XP_005263517
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VVEDTL 9
           VVEDTL
Sbjct: 635 VVEDTL 640
>XP_005263515
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VVEDTL 9
           VVEDTL
Sbjct: 676 VVEDTL 681
>NP_839943
          Length = 1631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VVEDTL 9
           VVEDTL
Sbjct: 222 VVEDTL 227
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.143    0.345 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 458,814
Number of extensions: 688
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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