Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              20     509
XP_005267290                                                           20     509
NP_055907                                                              17    3301
XP_006726695                                                           17    3301
XP_005255242                                                           17    3301
XP_005255241                                                           17    3301
XP_005255240                                                           17    3301
XP_005255239                                                           17    3301
NP_001275918                                                           17    4312
NP_057425                                                              17    4312
XP_006717952                                                           17    4312
XP_006717951                                                           17    4312
XP_006717950                                                           17    4312
XP_006717949                                                           17    4312
XP_006717948                                                           17    4312
NP_001184033                                                           16    5631
NP_005924                                                              16    5631
XP_006718903                                                           16    5631
XP_006718902                                                           16    5631
NP_061885                                                              16    7355
NP_001137378                                                           16    7355
NP_006691                                                              16    7355
NP_001243716                                                           16    7355
NP_001243399                                                           16    7355
NP_001137293                                                           16    7355
XP_006719159                                                           16    7355
XP_006719157                                                           16    7355
XP_006719156                                                           16    7355
XP_006719155                                                           16    7355
XP_005253457                                                           16    7355
XP_006719154                                                           16    7355
XP_005253456                                                           16    7355
XP_005253455                                                           16    7355
XP_006719153                                                           16    7355
XP_006719152                                                           16    7355
XP_006717206                                                           16    7355
XP_005252108                                                           16    7355
NP_005383                                                              16    7355
NP_001129599                                                           15    9605
NP_037396                                                              15    9605
XP_005271586                                                           15    9605
XP_005245137                                                           15    9605
>NP_005091
          Length = 1782

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  INSVAEQDE 9
          IN VAEQDE
Sbjct: 65 INGVAEQDE 73
>XP_005267290
          Length = 1782

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  INSVAEQDE 9
          IN VAEQDE
Sbjct: 65 INGVAEQDE 73
>NP_055907
          Length = 3661

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    INSVAEQDE 9
            INSVA+Q E
Sbjct: 1107 INSVAQQAE 1115
>XP_006726695
          Length = 747

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   INSVAEQDE 9
           INSVA+Q E
Sbjct: 622 INSVAQQAE 630
>XP_005255242
          Length = 3609

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    INSVAEQDE 9
            INSVA+Q E
Sbjct: 1055 INSVAQQAE 1063
>XP_005255241
          Length = 3637

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    INSVAEQDE 9
            INSVA+Q E
Sbjct: 1055 INSVAQQAE 1063
>XP_005255240
          Length = 3663

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    INSVAEQDE 9
            INSVA+Q E
Sbjct: 1081 INSVAQQAE 1089
>XP_005255239
          Length = 3689

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    INSVAEQDE 9
            INSVA+Q E
Sbjct: 1107 INSVAQQAE 1115
>NP_001275918
          Length = 2286

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NSVAEQD 8
           NSVAE+D
Sbjct: 127 NSVAEED 133
>NP_057425
          Length = 2302

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NSVAEQD 8
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717952
          Length = 2300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NSVAEQD 8
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717951
          Length = 2315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NSVAEQD 8
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717950
          Length = 2316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NSVAEQD 8
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717949
          Length = 2316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NSVAEQD 8
           NSVAE+D
Sbjct: 127 NSVAEED 133
>XP_006717948
          Length = 2316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NSVAEQD 8
           NSVAE+D
Sbjct: 127 NSVAEED 133
>NP_001184033
          Length = 3972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    INSVAEQDE 9
            INS  E DE
Sbjct: 2086 INSTVEHDE 2094
>NP_005924
          Length = 3969

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    INSVAEQDE 9
            INS  E DE
Sbjct: 2083 INSTVEHDE 2091
>XP_006718903
          Length = 2673

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   INSVAEQDE 9
           INS  E DE
Sbjct: 787 INSTVEHDE 795
>XP_006718902
          Length = 2964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    INSVAEQDE 9
            INS  E DE
Sbjct: 1078 INSTVEHDE 1086
>NP_061885
          Length = 1116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1059 NSVDEQEE 1066
>NP_001137378
          Length = 582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NSVAEQD 8
           +SVAEQD
Sbjct: 255 SSVAEQD 261
>NP_006691
          Length = 582

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   NSVAEQD 8
           +SVAEQD
Sbjct: 255 SSVAEQD 261
>NP_001243716
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1041 NSVDEQEE 1048
>NP_001243399
          Length = 1282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1225 NSVDEQEE 1232
>NP_001137293
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1117 NSVDEQEE 1124
>XP_006719159
          Length = 1276

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1219 NSVDEQEE 1226
>XP_006719157
          Length = 1128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1071 NSVDEQEE 1078
>XP_006719156
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1094 NSVDEQEE 1101
>XP_006719155
          Length = 1173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1116 NSVDEQEE 1123
>XP_005253457
          Length = 1179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1122 NSVDEQEE 1129
>XP_006719154
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1140 NSVDEQEE 1147
>XP_005253456
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1149 NSVDEQEE 1156
>XP_005253455
          Length = 1218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1161 NSVDEQEE 1168
>XP_006719153
          Length = 1224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1167 NSVDEQEE 1174
>XP_006719152
          Length = 1236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    NSVAEQDE 9
            NSV EQ+E
Sbjct: 1179 NSVDEQEE 1186
>XP_006717206
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   INSVAEQDE 9
           +N+VA  DE
Sbjct: 418 VNTVASSDE 426
>XP_005252108
          Length = 1097

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   INSVAEQDE 9
           +N+VA  DE
Sbjct: 453 VNTVASSDE 461
>NP_005383
          Length = 1096

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   INSVAEQDE 9
           +N+VA  DE
Sbjct: 453 VNTVASSDE 461
>NP_001129599
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVAEQDE 9
           SVAE DE
Sbjct: 626 SVAENDE 632
>NP_037396
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  INSVAEQDE 9
          IN++ E DE
Sbjct: 47 INNINEDDE 55
>XP_005271586
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  INSVAEQDE 9
          IN++ E DE
Sbjct: 47 INNINEDDE 55
>XP_005245137
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVAEQDE 9
           SVAE DE
Sbjct: 636 SVAENDE 642
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.290    0.112    0.259 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 498,639
Number of extensions: 659
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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