Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           20     509
NP_000170                                                              20     509
NP_001268422                                                           20     509
NP_001268423                                                           20     509
XP_005264328                                                           20     509
NP_001130005                                                           18    1935
NP_001273428                                                           17    2528
NP_001273425                                                           17    2528
NP_079325                                                              17    2528
NP_001273426                                                           17    2528
NP_653271                                                              17    3301
NP_001269353                                                           17    3301
NP_001167560                                                           17    4312
NP_114423                                                              17    4312
NP_001167561                                                           17    4312
XP_005260914                                                           17    4312
XP_005260913                                                           17    4312
NP_004447                                                              16    5631
NP_694543                                                              16    5631
NP_001190177                                                           16    5631
NP_001190178                                                           16    5631
NP_001190176                                                           16    5631
NP_001982                                                              16    5631
XP_005257203                                                           16    5631
XP_005257202                                                           16    5631
XP_005257201                                                           16    5631
XP_005250021                                                           16    5631
XP_006715950                                                           16    5631
XP_006715949                                                           16    5631
XP_006715948                                                           16    5631
XP_006715947                                                           16    5631
XP_005250020                                                           16    5631
XP_006715946                                                           16    5631
XP_005250019                                                           16    5631
NP_001171826                                                           16    7355
NP_055922                                                              16    7355
NP_001171825                                                           16    7355
NP_001171827                                                           16    7355
NP_061169                                                              16    7355
NP_003726                                                              16    7355
NP_115265                                                              16    7355
XP_006726853                                                           16    7355
XP_006724648                                                           16    7355
XP_005262057                                                           16    7355
XP_005262055                                                           16    7355
XP_005262056                                                           16    7355
XP_005262054                                                           16    7355
XP_005262053                                                           16    7355
XP_006723596                                                           16    7355
XP_005262765                                                           16    7355
XP_005262764                                                           16    7355
XP_006714135                                                           16    7355
XP_005262763                                                           16    7355
NP_057313                                                              15    9605
NP_001070993                                                           15    9605
NP_001010854                                                           15    9605
NP_071930                                                              15    9605
XP_005267424                                                           15    9605
XP_006720122                                                           15    9605
XP_006720121                                                           15    9605
XP_005253033                                                           15    9605
XP_006718315                                                           15    9605
XP_005253032                                                           15    9605
XP_006718314                                                           15    9605
XP_005253031                                                           15    9605
XP_006718313                                                           15    9605
XP_005253030                                                           15    9605
XP_006717969                                                           15    9605
XP_006717968                                                           15    9605
XP_006717967                                                           15    9605
XP_006717966                                                           15    9605
XP_006717965                                                           15    9605
XP_005265457                                                           15    9605
NP_001070994                                                           15    9605
>NP_001268421
          Length = 1230

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IMSGESIFF 9
            IMSGES FF
Sbjct: 1053 IMSGESTFF 1061
>NP_000170
          Length = 1360

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IMSGESIFF 9
            IMSGES FF
Sbjct: 1183 IMSGESTFF 1191
>NP_001268422
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IMSGESIFF 9
           IMSGES FF
Sbjct: 881 IMSGESTFF 889
>NP_001268423
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IMSGESIFF 9
           IMSGES FF
Sbjct: 881 IMSGESTFF 889
>XP_005264328
          Length = 1261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IMSGESIFF 9
            IMSGES FF
Sbjct: 1084 IMSGESTFF 1092
>NP_001130005
          Length = 631

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   IMSGESIF 8
           +MSGES+F
Sbjct: 94  LMSGESLF 101
>NP_001273428
          Length = 588

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IMSGESIFF 9
           ++ G+SIFF
Sbjct: 165 VLKGQSIFF 173
>NP_001273425
          Length = 641

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IMSGESIFF 9
           ++ G+SIFF
Sbjct: 218 VLKGQSIFF 226
>NP_079325
          Length = 641

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IMSGESIFF 9
           ++ G+SIFF
Sbjct: 218 VLKGQSIFF 226
>NP_001273426
          Length = 707

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IMSGESIFF 9
           ++ G+SIFF
Sbjct: 218 VLKGQSIFF 226
>NP_653271
          Length = 1454

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    IMSGESIFF 9
            I+SGESI++
Sbjct: 1165 IISGESIYW 1173
>NP_001269353
          Length = 963

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   IMSGESIFF 9
           I+SGESI++
Sbjct: 674 IISGESIYW 682
>NP_001167560
          Length = 875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  IMSGESIFF 9
          I+SGESI F
Sbjct: 59 IVSGESIRF 67
>NP_114423
          Length = 891

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  IMSGESIFF 9
          I+SGESI F
Sbjct: 75 IVSGESIRF 83
>NP_001167561
          Length = 918

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IMSGESIFF 9
           I+SGESI F
Sbjct: 102 IVSGESIRF 110
>XP_005260914
          Length = 856

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  IMSGESIFF 9
          I+SGESI F
Sbjct: 40 IVSGESIRF 48
>XP_005260913
          Length = 998

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IMSGESIFF 9
           I+SGESI F
Sbjct: 220 IVSGESIRF 228
>NP_004447
          Length = 751

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 721 IQTGEELFF 729
>NP_694543
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 677 IQTGEELFF 685
>NP_001190177
          Length = 737

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 707 IQTGEELFF 715
>NP_001190178
          Length = 695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 665 IQTGEELFF 673
>NP_001190176
          Length = 746

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 716 IQTGEELFF 724
>NP_001982
          Length = 747

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 717 IQAGEELFF 725
>XP_005257203
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 677 IQAGEELFF 685
>XP_005257202
          Length = 713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 683 IQAGEELFF 691
>XP_005257201
          Length = 753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 723 IQAGEELFF 731
>XP_005250021
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 673 IQTGEELFF 681
>XP_006715950
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 682 IQTGEELFF 690
>XP_006715949
          Length = 724

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 694 IQTGEELFF 702
>XP_006715948
          Length = 737

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 707 IQTGEELFF 715
>XP_006715947
          Length = 738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 708 IQTGEELFF 716
>XP_005250020
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 715 IQTGEELFF 723
>XP_006715946
          Length = 746

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 716 IQTGEELFF 724
>XP_005250019
          Length = 754

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I +GE +FF
Sbjct: 724 IQTGEELFF 732
>NP_001171826
          Length = 948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           ++ GE IF+
Sbjct: 259 VLKGEKIFY 267
>NP_055922
          Length = 1024

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           ++ GE IF+
Sbjct: 259 VLKGEKIFY 267
>NP_001171825
          Length = 1060

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           ++ GE IF+
Sbjct: 295 VLKGEKIFY 303
>NP_001171827
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           ++ GE IF+
Sbjct: 259 VLKGEKIFY 267
>NP_061169
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I  GE+IF+
Sbjct: 99  IQEGENIFY 107
>NP_003726
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   IMSGESIF 8
           ++SG+S+F
Sbjct: 792 LLSGDSVF 799
>NP_115265
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   IMSGESIF 8
           ++SG+S+F
Sbjct: 792 LLSGDSVF 799
>XP_006726853
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IMSGESIFF 9
          ++SGES+ F
Sbjct: 32 LISGESVTF 40
>XP_006724648
          Length = 931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           ++ GE IF+
Sbjct: 295 VLKGEKIFY 303
>XP_005262057
          Length = 984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           ++ GE IF+
Sbjct: 295 VLKGEKIFY 303
>XP_005262055
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           ++ GE IF+
Sbjct: 259 VLKGEKIFY 267
>XP_005262056
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           ++ GE IF+
Sbjct: 259 VLKGEKIFY 267
>XP_005262054
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           ++ GE IF+
Sbjct: 259 VLKGEKIFY 267
>XP_005262053
          Length = 1085

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           ++ GE IF+
Sbjct: 295 VLKGEKIFY 303
>XP_006723596
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IMSGESIFF 9
          ++SGES+ F
Sbjct: 32 LISGESVTF 40
>XP_005262765
          Length = 346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I  GE+IF+
Sbjct: 99  IQEGENIFY 107
>XP_005262764
          Length = 501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I  GE+IF+
Sbjct: 99  IQEGENIFY 107
>XP_006714135
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I  GE+IF+
Sbjct: 99  IQEGENIFY 107
>XP_005262763
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMSGESIFF 9
           I  GE+IF+
Sbjct: 99  IQEGENIFY 107
>NP_057313
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GESIFF 9
           GE+IFF
Sbjct: 112 GETIFF 117
>NP_001070993
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   IMSGESIFF 9
           +  GE IFF
Sbjct: 383 LSKGEEIFF 391
>NP_001010854
          Length = 843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IMSGESIF 8
           + SGE+IF
Sbjct: 312 VYSGENIF 319
>NP_071930
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   IMSGESIFF 9
           +  GE IFF
Sbjct: 383 LSKGEEIFF 391
>XP_005267424
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IMSGESIF 8
          + SGE+IF
Sbjct: 54 VYSGENIF 61
>XP_006720122
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IMSGESIF 8
           + SGE+IF
Sbjct: 218 VYSGENIF 225
>XP_006720121
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IMSGESIF 8
           + SGE+IF
Sbjct: 320 VYSGENIF 327
>XP_005253033
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GESIFF 9
           GE+IFF
Sbjct: 172 GETIFF 177
>XP_006718315
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GESIFF 9
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_005253032
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GESIFF 9
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_006718314
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GESIFF 9
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_005253031
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GESIFF 9
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_006718313
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GESIFF 9
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_005253030
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GESIFF 9
           GE+IFF
Sbjct: 172 GETIFF 177
>XP_006717969
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SGESIFF 9
          SGE +FF
Sbjct: 37 SGEPLFF 43
>XP_006717968
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SGESIFF 9
           SGE +FF
Sbjct: 550 SGEPLFF 556
>XP_006717967
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SGESIFF 9
           SGE +FF
Sbjct: 550 SGEPLFF 556
>XP_006717966
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SGESIFF 9
           SGE +FF
Sbjct: 550 SGEPLFF 556
>XP_006717965
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SGESIFF 9
           SGE +FF
Sbjct: 556 SGEPLFF 562
>XP_005265457
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   IMSGESIFF 9
           +  GE IFF
Sbjct: 358 LSKGEEIFF 366
>NP_001070994
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   IMSGESIFF 9
           +  GE IFF
Sbjct: 383 LSKGEEIFF 391
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.149    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 542,433
Number of extensions: 617
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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