Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              19     665
XP_006713721                                                           19     665
NP_976059                                                              17    3301
NP_976060                                                              17    3301
NP_004042                                                              17    3301
XP_005269412                                                           17    3301
XP_005269409                                                           17    3301
NP_006662                                                              16    5631
NP_001274524                                                           16    5631
NP_001274526                                                           16    5631
NP_075045                                                              16    7355
XP_005264558                                                           16    7355
XP_005264557                                                           16    7355
NP_001238936                                                           15    9605
NP_001238935                                                           15    9605
NP_116021                                                              15    9605
XP_005267339                                                           15    9605
XP_005267338                                                           15    9605
XP_005267337                                                           15    9605
XP_006717058                                                           15    9605
>NP_006209
          Length = 1068

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IMLGRMSNL 9
           IMLGRM NL
Sbjct: 277 IMLGRMPNL 285
>XP_006713721
          Length = 1068

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IMLGRMSNL 9
           IMLGRM NL
Sbjct: 277 IMLGRMPNL 285
>NP_976059
          Length = 343

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   MLGRMSN 8
           MLGRM+N
Sbjct: 196 MLGRMAN 202
>NP_976060
          Length = 343

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   MLGRMSN 8
           MLGRM+N
Sbjct: 196 MLGRMAN 202
>NP_004042
          Length = 343

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   MLGRMSN 8
           MLGRM+N
Sbjct: 196 MLGRMAN 202
>XP_005269412
          Length = 206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  MLGRMSN 8
          MLGRM+N
Sbjct: 59 MLGRMAN 65
>XP_005269409
          Length = 343

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   MLGRMSN 8
           MLGRM+N
Sbjct: 196 MLGRMAN 202
>NP_006662
          Length = 560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IMLGRMSN 8
           IMLGRM +
Sbjct: 234 IMLGRMGD 241
>NP_001274524
          Length = 619

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IMLGRMSN 8
           IMLGRM +
Sbjct: 234 IMLGRMGD 241
>NP_001274526
          Length = 472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IMLGRMSN 8
           IMLGRM +
Sbjct: 162 IMLGRMGD 169
>NP_075045
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  IMLGRMSNL 9
          ++LG+++NL
Sbjct: 62 VVLGKLNNL 70
>XP_005264558
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  IMLGRMSNL 9
          ++LG+++NL
Sbjct: 18 VVLGKLNNL 26
>XP_005264557
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  IMLGRMSNL 9
          ++LG+++NL
Sbjct: 62 VVLGKLNNL 70
>NP_001238936
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  IMLGRMSNL 9
          ++LG+++NL
Sbjct: 63 LILGKLNNL 71
>NP_001238935
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  IMLGRMSNL 9
          ++LG+++NL
Sbjct: 63 LILGKLNNL 71
>NP_116021
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  IMLGRMSNL 9
          ++LG+++NL
Sbjct: 63 LILGKLNNL 71
>XP_005267339
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  IMLGRMSNL 9
          ++LG+++NL
Sbjct: 63 LILGKLNNL 71
>XP_005267338
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  IMLGRMSNL 9
          ++LG+++NL
Sbjct: 63 LILGKLNNL 71
>XP_005267337
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  IMLGRMSNL 9
          ++LG+++NL
Sbjct: 63 LILGKLNNL 71
>XP_006717058
          Length = 2100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IMLGRMSNL 9
            + LG+ SNL
Sbjct: 2068 VFLGQQSNL 2076
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.145    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 356,225
Number of extensions: 598
Number of successful extensions: 20
Number of sequences better than 10000.0: 20
Number of HSP's gapped: 20
Number of HSP's successfully gapped: 20
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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