Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           21     229
NP_858045                                                              21     229
NP_006525                                                              21     229
NP_001167559                                                           21     229
NP_001008395                                                           17    2528
NP_036474                                                              17    2528
NP_000262                                                              16    7355
NP_008944                                                              16    7355
NP_542402                                                              16    7355
XP_006722542                                                           16    7355
XP_005258336                                                           16    7355
XP_005258335                                                           16    7355
XP_005258334                                                           16    7355
XP_005250818                                                           16    7355
XP_005250817                                                           16    7355
NP_072088                                                              16    7355
NP_001842                                                              15    9605
NP_001035203                                                           15    9605
NP_074035                                                              15    9605
NP_001035202                                                           15    9605
NP_002465                                                              15    9605
NP_002464                                                              15    9605
NP_002968                                                              15    9605
NP_001273148                                                           15    9605
NP_001242941                                                           15    9605
NP_004935                                                              15    9605
NP_057062                                                              15    9605
NP_001139281                                                           15    9605
NP_005955                                                              15    9605
NP_001070654                                                           15    9605
NP_443139                                                              15    9605
NP_001032961                                                           15    9605
NP_079005                                                              15    9605
NP_057400                                                              15    9605
NP_001106279                                                           15    9605
NP_001243024                                                           15    9605
XP_006723449                                                           15    9605
XP_005256710                                                           15    9605
XP_005256709                                                           15    9605
XP_005256708                                                           15    9605
XP_006719284                                                           15    9605
XP_006719283                                                           15    9605
XP_006719282                                                           15    9605
XP_005246814                                                           15    9605
XP_006712656                                                           15    9605
XP_005264025                                                           15    9605
XP_006712655                                                           15    9605
>NP_001167558
          Length = 1423

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   MEPMNSNS 9
           MEPMNSNS
Sbjct: 930 MEPMNSNS 937
>NP_858045
          Length = 1424

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   MEPMNSNS 9
           MEPMNSNS
Sbjct: 930 MEPMNSNS 937
>NP_006525
          Length = 1420

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   MEPMNSNS 9
           MEPMNSNS
Sbjct: 930 MEPMNSNS 937
>NP_001167559
          Length = 1415

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   MEPMNSNS 9
           MEPMNSNS
Sbjct: 925 MEPMNSNS 932
>NP_001008395
          Length = 333

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IMEPMNSN 8
           I+EPMN N
Sbjct: 282 ILEPMNVN 289
>NP_036474
          Length = 260

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IMEPMNSNS 9
          +++P NSNS
Sbjct: 55 LLDPQNSNS 63
>NP_000262
          Length = 1278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEPMNS 7
           MEPMN+
Sbjct: 217 MEPMNN 222
>NP_008944
          Length = 922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IMEPMNSNS 9
           I+EP  SNS
Sbjct: 310 ILEPDTSNS 318
>NP_542402
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  MEPMNS 7
          MEP+NS
Sbjct: 55 MEPLNS 60
>XP_006722542
          Length = 1273

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEPMNS 7
           MEPMN+
Sbjct: 217 MEPMNN 222
>XP_005258336
          Length = 1286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEPMNS 7
           MEPMN+
Sbjct: 217 MEPMNN 222
>XP_005258335
          Length = 1295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEPMNS 7
           MEPMN+
Sbjct: 217 MEPMNN 222
>XP_005258334
          Length = 1303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MEPMNS 7
           MEPMN+
Sbjct: 217 MEPMNN 222
>XP_005250818
          Length = 921

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IMEPMNSNS 9
           I+EP  SNS
Sbjct: 309 ILEPDTSNS 317
>XP_005250817
          Length = 922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IMEPMNSNS 9
           I+EP  SNS
Sbjct: 310 ILEPDTSNS 318
>NP_072088
          Length = 362

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MEPMNSNS 9
           + P+NSNS
Sbjct: 353 LPPVNSNS 360
>NP_001842
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  PMNSNS 9
          P+NSNS
Sbjct: 32 PVNSNS 37
>NP_001035203
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 603 MDPLNDN 609
>NP_074035
          Length = 1938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 596 MDPLNDN 602
>NP_001035202
          Length = 1945

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 603 MDPLNDN 609
>NP_002465
          Length = 1972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 596 MDPLNDN 602
>NP_002464
          Length = 1960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 589 MDPLNDN 595
>NP_002968
          Length = 1977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EPMNSN 8
            EPMNS+
Sbjct: 1133 EPMNSD 1138
>NP_001273148
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EPMNSN 8
           EPMNS+
Sbjct: 524 EPMNSS 529
>NP_001242941
          Length = 2007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 606 MDPLNDN 612
>NP_004935
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IMEPMNSNS 9
          +ME +N NS
Sbjct: 71 LMEKLNRNS 79
>NP_057062
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMEPMNSNS 9
           +M P +SNS
Sbjct: 728 LMSPASSNS 736
>NP_001139281
          Length = 2036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 623 MDPLNDN 629
>NP_005955
          Length = 1976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 596 MDPLNDN 602
>NP_001070654
          Length = 2003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 623 MDPLNDN 629
>NP_443139
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EPMNSN 8
            EPMNS+
Sbjct: 1012 EPMNSS 1017
>NP_001032961
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    IMEPMNSNS 9
            I EP  SNS
Sbjct: 992  IPEPQESNS 1000
>NP_079005
          Length = 1995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 615 MDPLNDN 621
>NP_057400
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    IMEPMNSNS 9
            I EP  SNS
Sbjct: 993  IPEPQESNS 1001
>NP_001106279
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IMEPMNSNS 9
           +M P +SNS
Sbjct: 842 LMSPASSNS 850
>NP_001243024
          Length = 1985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 605 MDPLNDN 611
>XP_006723449
          Length = 2003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 623 MDPLNDN 629
>XP_005256710
          Length = 1986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 606 MDPLNDN 612
>XP_005256709
          Length = 1997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 596 MDPLNDN 602
>XP_005256708
          Length = 2007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   MEPMNSN 8
           M+P+N N
Sbjct: 606 MDPLNDN 612
>XP_006719284
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EPMNSN 8
           EPMNS+
Sbjct: 610 EPMNSS 615
>XP_006719283
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EPMNSN 8
           EPMNS+
Sbjct: 902 EPMNSS 907
>XP_006719282
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EPMNSN 8
           EPMNS+
Sbjct: 902 EPMNSS 907
>XP_005246814
          Length = 1988

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    EPMNSN 8
            EPMNS+
Sbjct: 1144 EPMNSD 1149
>XP_006712656
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IMEPMNSNS 9
           I EP  SNS
Sbjct: 503 IPEPQESNS 511
>XP_005264025
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IMEPMNSNS 9
           I EP  SNS
Sbjct: 923 IPEPQESNS 931
>XP_006712655
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    IMEPMNSNS 9
            I EP  SNS
Sbjct: 993  IPEPQESNS 1001
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.112    0.292 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 662,123
Number of extensions: 1100
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package