Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              18    1135
XP_005271621                                                           18    1135
XP_006718907                                                           18    1135
XP_006718906                                                           18    1135
XP_005271619                                                           18    1135
XP_005271618                                                           18    1135
NP_002635                                                              16    7355
NP_001243470                                                           16    7355
NP_078876                                                              16    7355
XP_006722005                                                           16    7355
XP_005273220                                                           16    7355
NP_001182311                                                           15    9605
NP_001182310                                                           15    9605
NP_001230175                                                           15    9605
NP_071751                                                              15    9605
NP_001139761                                                           15    9605
XP_005264808                                                           15    9605
XP_005264807                                                           15    9605
XP_005264806                                                           15    9605
XP_005264805                                                           15    9605
XP_005264804                                                           15    9605
XP_005271167                                                           15    9605
NP_000857                                                              15    9605
>NP_000042
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILVSLTMNN 9
           ILVSLTM N
Sbjct: 611 ILVSLTMKN 619
>XP_005271621
          Length = 2708

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILVSLTMNN 9
           ILVSLTM N
Sbjct: 263 ILVSLTMKN 271
>XP_006718907
          Length = 3050

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILVSLTMNN 9
           ILVSLTM N
Sbjct: 611 ILVSLTMKN 619
>XP_006718906
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILVSLTMNN 9
           ILVSLTM N
Sbjct: 611 ILVSLTMKN 619
>XP_005271619
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILVSLTMNN 9
           ILVSLTM N
Sbjct: 611 ILVSLTMKN 619
>XP_005271618
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILVSLTMNN 9
           ILVSLTM N
Sbjct: 611 ILVSLTMKN 619
>NP_002635
          Length = 764

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LVSLTMN 8
           LVSLT+N
Sbjct: 526 LVSLTLN 532
>NP_001243470
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LVSLTMNN 9
          LVSL +NN
Sbjct: 15 LVSLILNN 22
>NP_078876
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LVSLTMNN 9
          LVSL +NN
Sbjct: 15 LVSLILNN 22
>XP_006722005
          Length = 137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ILVSLTMN 8
          + VSLTMN
Sbjct: 45 VSVSLTMN 52
>XP_005273220
          Length = 773

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LVSLTMN 8
           LVSLT+N
Sbjct: 526 LVSLTLN 532
>NP_001182311
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VSLTMN 8
          VSLTMN
Sbjct: 28 VSLTMN 33
>NP_001182310
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VSLTMN 8
          VSLTMN
Sbjct: 28 VSLTMN 33
>NP_001230175
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VSLTMNN 9
           +SLTMN+
Sbjct: 457 ISLTMNS 463
>NP_071751
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VSLTMNN 9
           +SLTMN+
Sbjct: 457 ISLTMNS 463
>NP_001139761
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VSLTMNN 9
           +SLTMN+
Sbjct: 457 ISLTMNS 463
>XP_005264808
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  ILVSLTMN 8
          ILVSLT++
Sbjct: 24 ILVSLTLS 31
>XP_005264807
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  ILVSLTMN 8
          ILVSLT++
Sbjct: 24 ILVSLTLS 31
>XP_005264806
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  ILVSLTMN 8
          ILVSLT++
Sbjct: 24 ILVSLTLS 31
>XP_005264805
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  ILVSLTMN 8
          ILVSLT++
Sbjct: 24 ILVSLTLS 31
>XP_005264804
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  ILVSLTMN 8
          ILVSLT++
Sbjct: 24 ILVSLTLS 31
>XP_005271167
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VSLTMNN 9
           +SLTMN+
Sbjct: 121 ISLTMNS 127
>NP_000857
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  ILVSLTMN 8
          ILVSLT++
Sbjct: 24 ILVSLTLS 31
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.131    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 305,502
Number of extensions: 399
Number of successful extensions: 23
Number of sequences better than 10000.0: 23
Number of HSP's gapped: 23
Number of HSP's successfully gapped: 23
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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