Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              17    2528
XP_005250102                                                           17    2528
NP_001070665                                                           17    4312
NP_001070664                                                           17    4312
NP_058649                                                              17    4312
NP_001070826                                                           17    4312
NP_612382                                                              16    5631
NP_001018655                                                           16    5631
NP_001277117                                                           16    5631
NP_001277118                                                           16    5631
NP_001018656                                                           16    5631
NP_001277121                                                           16    5631
NP_001277120                                                           16    5631
NP_001277123                                                           16    5631
NP_001018657                                                           16    5631
NP_001277122                                                           16    5631
NP_001277119                                                           16    5631
NP_001018654                                                           16    5631
NP_075266                                                              16    7355
NP_004449                                                              16    7355
XP_006724698                                                           16    7355
XP_005262167                                                           16    7355
XP_005262166                                                           16    7355
XP_005262165                                                           16    7355
XP_006723933                                                           16    7355
XP_005260589                                                           16    7355
NP_056093                                                              15    9605
NP_071442                                                              15    9605
XP_005266932                                                           15    9605
XP_006715469                                                           15    9605
XP_005266931                                                           15    9605
XP_006714215                                                           15    9605
XP_006714214                                                           15    9605
XP_005262915                                                           15    9605
NP_055806                                                              15    9605
>NP_004324
          Length = 766

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           IL SIELLA
Sbjct: 710 ILASIELLA 718
>XP_005250102
          Length = 767

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           IL SIELLA
Sbjct: 710 ILASIELLA 718
>NP_001070665
          Length = 683

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT +E+LA
Sbjct: 438 ILTEVEILA 446
>NP_001070664
          Length = 489

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT +E+LA
Sbjct: 244 ILTEVEILA 252
>NP_058649
          Length = 933

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT +E+LA
Sbjct: 688 ILTEVEILA 696
>NP_001070826
          Length = 575

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT +E+LA
Sbjct: 330 ILTEVEILA 338
>NP_612382
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001018655
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001277117
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001277118
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001018656
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001277121
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001277120
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001277123
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001018657
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001277122
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001277119
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_001018654
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           ILT+I LLA
Sbjct: 298 ILTAINLLA 306
>NP_075266
          Length = 711

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILTSIELL 8
           ++TS+ELL
Sbjct: 201 LITSVELL 208
>NP_004449
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILTSIELL 8
           ++TS+ELL
Sbjct: 160 LITSVELL 167
>XP_006724698
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILTSIELL 8
           ++TS+ELL
Sbjct: 160 LITSVELL 167
>XP_005262167
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILTSIELL 8
           ++TS+ELL
Sbjct: 160 LITSVELL 167
>XP_005262166
          Length = 711

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILTSIELL 8
           ++TS+ELL
Sbjct: 201 LITSVELL 208
>XP_005262165
          Length = 711

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILTSIELL 8
           ++TS+ELL
Sbjct: 201 LITSVELL 208
>XP_006723933
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  ILTSIELL 8
          ILTS ELL
Sbjct: 8  ILTSCELL 15
>XP_005260589
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  ILTSIELL 8
          ILTS ELL
Sbjct: 8  ILTSCELL 15
>NP_056093
          Length = 1247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILTSIELL 8
           +LT++ELL
Sbjct: 687 LLTAVELL 694
>NP_071442
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           I+T IE+LA
Sbjct: 159 IITYIEILA 167
>XP_005266932
          Length = 1008

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILTSIELL 8
           +LT++ELL
Sbjct: 448 LLTAVELL 455
>XP_006715469
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILTSIELL 8
           +LT++ELL
Sbjct: 675 LLTAVELL 682
>XP_005266931
          Length = 1283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILTSIELL 8
           +LT++ELL
Sbjct: 723 LLTAVELL 730
>XP_006714215
          Length = 3544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           +LT+I LLA
Sbjct: 144 LLTTINLLA 152
>XP_006714214
          Length = 3544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           +LT+I LLA
Sbjct: 144 LLTTINLLA 152
>XP_005262915
          Length = 3544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           +LT+I LLA
Sbjct: 144 LLTTINLLA 152
>NP_055806
          Length = 3526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTSIELLA 9
           +LT+I LLA
Sbjct: 126 LLTTINLLA 134
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.142    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 354,789
Number of extensions: 460
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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