Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_570711                                                              19     665
NP_570712                                                              19     665
NP_570714                                                              19     665
NP_570713                                                              19     665
NP_570716                                                              19     665
NP_000235                                                              19     665
NP_570715                                                              19     665
XP_006718620                                                           19     665
XP_005274059                                                           19     665
XP_005274060                                                           19     665
XP_005274058                                                           19     665
NP_599152                                                              18    1935
NP_443166                                                              18    1935
XP_006711207                                                           18    1935
NP_056327                                                              17    3301
XP_006713163                                                           17    3301
NP_058644                                                              17    4312
NP_001032358                                                           17    4312
XP_006721257                                                           17    4312
XP_006721256                                                           17    4312
XP_005256034                                                           17    4312
NP_597996                                                              17    4312
NP_002147                                                              15    9605
NP_955472                                                              15    9605
XP_005246575                                                           15    9605
>NP_570711
          Length = 610

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 152 LDSSGVAF 159
>NP_570712
          Length = 615

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 157 LDSSGVAF 164
>NP_570714
          Length = 615

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 157 LDSSGVAF 164
>NP_570713
          Length = 615

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 157 LDSSGVAF 164
>NP_570716
          Length = 615

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 157 LDSSGVAF 164
>NP_000235
          Length = 615

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 157 LDSSGVAF 164
>NP_570715
          Length = 615

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 157 LDSSGVAF 164
>XP_006718620
          Length = 610

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 152 LDSSGVAF 159
>XP_005274059
          Length = 610

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 152 LDSSGVAF 159
>XP_005274060
          Length = 610

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 152 LDSSGVAF 159
>XP_005274058
          Length = 610

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LDSSGVAF 9
           LDSSGVAF
Sbjct: 152 LDSSGVAF 159
>NP_599152
          Length = 887

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILDSSGVAF 9
           ILD SGV+F
Sbjct: 666 ILDMSGVSF 674
>NP_443166
          Length = 791

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILDSSGVAF 9
           ILD SGV+F
Sbjct: 666 ILDMSGVSF 674
>XP_006711207
          Length = 791

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   ILDSSGVAF 9
           ILD SGV+F
Sbjct: 666 ILDMSGVSF 674
>NP_056327
          Length = 4265

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILDSSGVAF 9
           +LDSSGV +
Sbjct: 664 VLDSSGVHY 672
>XP_006713163
          Length = 4265

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILDSSGVAF 9
           +LDSSGV +
Sbjct: 664 VLDSSGVHY 672
>NP_058644
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DSSGVAF 9
           DSSG+AF
Sbjct: 99  DSSGLAF 105
>NP_001032358
          Length = 345

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DSSGVAF 9
           DSSG+AF
Sbjct: 98  DSSGLAF 104
>XP_006721257
          Length = 287

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  DSSGVAF 9
          DSSG+AF
Sbjct: 40 DSSGLAF 46
>XP_006721256
          Length = 342

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DSSGVAF 9
           DSSG+AF
Sbjct: 95  DSSGLAF 101
>XP_005256034
          Length = 357

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DSSGVAF 9
           DSSG+AF
Sbjct: 110 DSSGLAF 116
>NP_597996
          Length = 563

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ILDSSGVAF 9
           +LD SGV F
Sbjct: 468 VLDFSGVTF 476
>NP_002147
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILDSSGVA 8
           +LD++GVA
Sbjct: 529 LLDAAGVA 536
>NP_955472
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILDSSGVA 8
           +LD++GVA
Sbjct: 529 LLDAAGVA 536
>XP_005246575
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   ILDSSGVA 8
           +LD++GVA
Sbjct: 529 LLDAAGVA 536
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.140    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 509,066
Number of extensions: 615
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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